{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022J0cGBHx+BpxMi\\\\\\\\\\\\\\\/Yg5EFfnix1eUzULJ3Cfckk83pobdjbJAaSAP3yMX25T7QPVs2gxL9vnqgkBADf8sB4rvHEIb53\\\\\\\\\\\\\\\/gV1O5h31BW\\\\\\\\\\\\\\\/ISOyQ7\\\\\\\\\\\\\\\/SCPwKexYUv9hbFX2N55kGgmkLsKogGV\\\\\\\\\\\\\\\/Q8DhTf5XIyt44hK5olldeYYPEOTJoKTN3RjiDiwZ71egd4FumHjxmH7ZqZiA3Q2v8DPsbmki\\\\\\\\\\\\\\\/xB+D0n7m1OIdNeOBrfYG9I\\\\\\\\\\\\\\\/C+K5C3YpJcNelAY+dR7d21RVDc8yPZCNYtXDgr1TbQ+cv02aC8DwpDZlb05lKKRvmMPJmRQuzVNPB3ALCUDApqDTZDyNw1ydEy8m2ReM1Zz3BkIQw3XQ1qhAJjIBZwNr25DU4wwHay2UrHVVrCXR9dgESAae2zE\\\\\\\\\\\\\\\/8cWyiKVv5fmMswz+5V+UQVh6Y6X6w8aXF26GzaNGw1QMhYcjcuk3740\\\\\\\\\\\\\\\/Ht2TSkN20oemI1DOPyk9cdhb7N2NsfxL7Aj\\\\\\\\\\\\\\\/jeyS7Hcudz+A3knrcHMxBzKUMmU3f+pzFKa4EF2q352Mgx93z2mwNJUQLKlUEJgTkpS53\\\\\\\\\\\\\\\/V7BmQXlXa3zZHwQECebvLA2A5x2\\\\\\\\\\\\\\\/Cizu89UrD+VAObgOdxQuRSY8m2MqYJVbOCJ6DSKSZQanNx4q6pK2S5PFdpigR6FAzjNhXQEhI6cmhrzin7t5dzAX66Xnc6+Opn68zRauKfIOl00oCVvHLGeTQBgGlSIpSPjc+OyftR5SCuf3EMZ5FJhwJyOzPfEdB557sz4i\\\\\\\\\\\\\\\/7CRJ6tBzuLg\\\\\\\\\\\\\\\/m1wfKKavbI9Uf3HkwMxeV\\\\\\\\\\\\\\\/8pEiIXLjgAFkG823wH2e1FcmSdM8ri73Y+wmCEngfvZEUlwnj5X+qC3Vzo477KSH\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/25aMU+oPrcvzbDEqmdW0YREiimVLrVlX3jdx671Z0PDFazwDCL4\\\\\\\\\\\\\\\/TEDHSwEwZuWpQfYxIC50Y90a8EFpcT73b7fMNyua\\\\\\\\\\\\\\\/vvGJIjXwWjIzc70FhXljV5jsvLSSCYtyQ+\\\\\\\\\\\\\\\/mKHMRx891FMCKb6A5mMYLTCRxC52NB0ebOO2FFdB7roW5DfMG7QXkHCYkYF5MBphZ4+s4VKiLtReaiGStDcwM7vbMD4BNZY2JJEToWtA3lxY25YIxDM0UdqrdDkLbnP4vssxvKjNz51IvEu2xIDw9EgE\\\\\\\\\\\\\\\/bGapJsvpxGAE3z2GZ9uMtRkEurbiE8b3v59lnS2+i\\\\\\\\\\\\\\\/6sNiO75etf\\\\\\\\\\\\\\\/MAsmdjFwz22A4HkEFOGF4wwNwMoNYzC8gkDv4zvQSbXJ+cfvrE4ucN+Pq2xWboeG3dzVBQpWRihsGD4FcSjVD0HYn6yIxqR9avVf\\\\\\\\\\\\\\\/yneXZokcupmoTjR8r20Kr08TN6fTob5M7lQdMfmL\\\\\\\\\\\\\\\/kWZxyvGUic3k4hfmWfP+c0R9xo\\\\\\\\\\\\\\\/gw7MLv+qootTkIk2RLW7y1CnT7FM+QhNRmStbAXVukEPwB4rFxnazf14Vmeq2CuHXLKQqYtyCRkS4nDqlrbs5WkhDEl76rGsl9gWuheMfFVpYKM5qBQI3lFDzvuN2UY9+LxIx6EOdhD0w4jZ10l5mE8NNA+jzJhSkagOz2zkRrkR8eAKOEW1ZzKYGSZsJFz9J2dyh3t\\\\\\\\\\\\\\\/Olzoh+c07j0HkQC2fwgUatvk64smGxGPpHgeVq+wncL0jJLIx4sbSmrV5erVH6Fgls4yDCDPbcjxgmOZUntygjYhFAii+nWXhoxDtbYCOxQgAzqV+ov7aWcmXm0aRoKuRUN6bnIxKYitkCz8nPp\\\\\\\\\\\\\\\/hMKnYW0Pl5V\\\\\\\\\\\\\\\/2aZBhDSaj6fB58C9E7AzPailAzrgDh5CDkA96uGELjFfZ1G\\\\\\\\\\\\\\\/6EfU54\\\\\\\\\\\\\\\/v8Lkeh5TWFKen2Ywvra1\\\\\\\\\\\\\\\/7icHB7nrTjAu4fqeVaXECByDMWV5OXzUbYuJIoOOZIGnzx6OnF2jU6Vf\\\\\\\\\\\\\\\/hSeS4EBUTvlC8Him8Vk3Sn8aPqGTB4D2PlzJfS+PKX6wYzpBD7QF6bdjo3InXAKpk4C+oU63Hmy138cxrH2ZvQX4k9C6AnLUfNqXNQKxMO08q2Na0bpEf0zdmptqwqKV5jWdLxJTTIF3Hn\\\\\\\\\\\\\\\/B+IyDkOWaiCAupmE+POWMxJuHPMHNtkNf8+87ch\\\\\\\\\\\\\\\/GpkOwGfCTJ6bwwoggbaqaVIiGJVi+spTMlQoX1sVvWsNxQNE4uhyqDzgLQObb9OL8KbSql9Z2jLJNyqLzl9f7f\\\\\\\\\\\\\\\/+P05iitOyV8ml9VKLboMsWnbmXEwTWmVtYdw37YheJ8wQW4wJ8eLCnm7sAn6S9TdYHUgjlMEjjYvNbi3DvPCSqap0gOkUA5kkDvIhacrMd36\\\\\\\\\\\\\\\/jd607KhH85Ip+Neh6PqyG2rZeL2ows709XfT\\\\\\\\\\\\\\\/aH89EcyYW5SsEBtrRgIcrqKlzBjOaKM\\\\\\\\\\\\\\\/CTV1IM9wAMr9lLfhD4htu8c3H1JdIJ5qppdFkvVwkd33ZplkAsEzZ4bww2CZGVB7Rfe\\\\\\\\\\\\\\\/Qa8l8sM4YjZxeXIh\\\\\\\\\\\\\\\/oveqP8zFW9++6r7iJXAcOU471s2MhkKnhA9xsjFYt5YSQIbfm3gWSkQfbo96DbBCiYkPjuBTP+kJ+nxn42ks+1gETJDrLzLK8C6gYe2HyHN13nKlP09CPlh2HEunyc0BlMuM4jDDDHlc0liyjnUxdAPhUzzB7ssORfbVDQh47qUwTeWWXqKh1MBbgUYlzkCsAj9hKafsS5AqetEx7pEZ8MBCR+F8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ZJZA0iNNJ8Ytf75oJlD5hw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022cc68d2d6ded285cc54e5f14b4789cec2a7ff53acdb0878d0c80bce8b871129a8\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A82.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A82.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0136\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0136\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-SITC2020.0136\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}