{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022IpsMZw+iu5mmV0B2T+nBI3aPm1uQokOEGOBoOZIQMzVWaFSp1Mz9xir\\\\\\\\\\\\\\\/xH\\\\\\\\\\\\\\\/6upglUnB0A5xZ+jeF3pwtQ2Fbtwmd5ton3elYiqC37PE780z52Ii\\\\\\\\\\\\\\\/KuP7DmLLNHdZ30iWm96h1HNCje0JLEx82lX6nliTtnI9geEfnGowp8kJy1GeYnS2\\\\\\\\\\\\\\\/xabi7QwXmtTL7DE4JQKeU5hYY0S\\\\\\\\\\\\\\\/dx97ot5ci\\\\\\\\\\\\\\\/p\\\\\\\\\\\\\\\/0cMgqDHrnAixzjHN5HWSMq8eb5yTLH4aV+WvNndc737F75ODR4J4UBUJYz3a2MnGvIWmbw9dVPo19F7ZvoWkIjMcJ+A6e\\\\\\\\\\\\\\\/2LJ6aF7h7ddziM5gGuWK3dVlcW\\\\\\\\\\\\\\\/wihpSXdyVETKWGjD8tUL1AIMJ820rQ6f424\\\\\\\\\\\\\\\/wWM\\\\\\\\\\\\\\\/LHzspXC6tXDyXJnwFgvObkRlA1Xvf+jHQDQtd7pC7aVZIrZFvonBbbMNI1tyK8EqQPrqqc19MlP6FzNKk\\\\\\\\\\\\\\\/8+hntIMHqsCkVwMJr9VLw60FznHY+yTEhaio3akXdcs\\\\\\\\\\\\\\\/Mk4149VaXGNN\\\\\\\\\\\\\\\/fZxCw9ihr+6TfqPBMDHNjNKMLvfRyTDiWAYyQN43jMYcxLOQhGw5F4I5XGek79CUhwnLQF1WL7oQdlqP5A7v+dc03rO4yE8UU3\\\\\\\\\\\\\\\/kAiWHPm7exzj\\\\\\\\\\\\\\\/wCv4sZnJzsLsoq27mZVlhhRIcJg3ai1w3hYAGptu8tHF3flfXKi2Mv0gmaRZ+HZVKfstOISKcZIIsl9TRm6CkGzu\\\\\\\\\\\\\\\/dVJdXZQzE7nMDKAKfCjIFL9UxIjTX+83KSzSX64S+qQsHbwNDa06eysxZtmEzjvSH+h3BfYdyKGcD7W\\\\\\\\\\\\\\\/yQiGNDSqbZixcbSBJLfMLZ7P\\\\\\\\\\\\\\\/0d214Kh0XWraWccYqTwPm6KJ1uio2HJIUVN0tvypa1zihsGe2Ecc8JJ4LGncMHMvJwgyOIzu38frqrRDHfAdtrHGiTtM+YkLY7LufsU6y0tESHflYcgtWqB8dQ5ZOKv+7VAI3xjThIBGW7qKfiRQ2qwcEA4ckKkDcXsA1UmfqqcW0q9RgR18OgGgNOyaalfkWktPgXSmH1MzDK\\\\\\\\\\\\\\\/UyBgDkTVRkBH2zhCWAfy25F10nPnkCtwoeo4HxhOSnoxas61LKNq6iH0B54ElpuKWZ+oFhZCiPTUTliqNE3mVuMVbrl0GmgMJOoOFWcCoerx9xdHO+h6tHI0M7JLTuqUFu6SCvN6bR01e5vi4og5G6\\\\\\\\\\\\\\\/XB0UeYvTtry9kz02dRM8UVG1WRiPqolsCirnY6GndIULuCKxw5pybOJC5r7RoWu168hVFLHs\\\\\\\\\\\\\\\/8o5ivnQbjoMMUNL7YY+X+XLBljonJUNTQWRWBwgFucl+2rFx9jxwLSy4uRMxOQLxbtNVRVb+W\\\\\\\\\\\\\\\/N8dbZuQ3RmkU0m46Qh8C6EG8qC4pAYPbkOG23rBk7pfktsnC4F+k9Psxt70kE+fQCwhfO7neeTxvUz7ulkytuxo2yXrOZ3\\\\\\\\\\\\\\\/i8Q4iRvGrUW\\\\\\\\\\\\\\\/F0n7eBdaRI609Iz2+AwrKP+KCyHpH986JMx5U4GVjKO\\\\\\\\\\\\\\\/FCCFkn9LJHADem9kIn\\\\\\\\\\\\\\\/qjwjcB1ge9hFGHt6elCJFnceaCweXie0tMmhq5FLlINamQ6DJNlk8u+4YPtwX7av+4FvtPNrERy2aU+9DRGNKkh97LFWzicQipx4F2tM94lrjm0vKFQUVRnOIxHjNSAp\\\\\\\\\\\\\\\/p971soHWwEpfc3pSd5jiayhKcyaPkBkCxr7sCPr9hwXAE6aKs4KpLAH9saG5JzUH2ziAXRKzYGHRO8ryRV39a6zy5mV4oDziYsS3cqQ0qIgp6KBUU2YUlbkO\\\\\\\\\\\\\\\/nz26ZgZke961agYdgDw6H6yhNcgVLyxJafz0U3XLLe8LfYyYaffvtbw2yLCEaSwN0cLcxBWwgyi6b74OddbN3oEUV4zQWjeW2u0oC\\\\\\\\\\\\\\\/z9i08RPlyAgW9a7\\\\\\\\\\\\\\\/a9\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/bgXEI7E5m0wqX5DLcHemR81mV36qeAVrzq6EX5Se8TqLvHawGrqr7RPHORuwdUFrvc6fSU2pVi\\\\\\\\\\\\\\\/VsxGzXmyVLXIaz7KAOvRmpAmUsDnya+lcl4SkpJnbpbgptgQMXTqG2kEyu+lJ4KAy2dpzk0f42PHH0hHbFrnPfeECzQ0rXg3uu6IGjIOkikNe+1evaEayRWuRJJkCha5m3lVar9U4TkI4ayBlr3PnfV7ApF4QpLEie0Ft6cq6p2H4vhQMj1\\\\\\\\\\\\\\\/1\\\\\\\\\\\\\\\/PXUtECkfH7KTEjivY5puHM0hNxioJtM7d23iy7nWsp4HAtMfXT8RQ\\\\\\\\\\\\\\\/U8t\\\\\\\\\\\\\\\/TQCG8lcjPFoFMEpxBcITyWBwQQgexatUxGSveleHaFd2UWlwq+lMFeC\\\\\\\\\\\\\\\/bXydlt+L2+LdiTASVYfV7C\\\\\\\\\\\\\\\/op7iTWEOWXet53ZOLTWWvVsTJIYXPISlNH8+GnzfyIwRbMBT1NUfFtOY67DAm21DpWY4isoGCAmZi5+996e4iUKxPTaJaOvxGWmojbHWGK9okENDmEgi\\\\\\\\\\\\\\\/af4J9axgLUTXINXba\\\\\\\\\\\\\\\/T8tz0NBfKgddhliTx43fbjerZLiXpLKu8TGbJlfTgDIla3m+4D+buRsvxR7R5zDnuws7R+ThpqbiKMlIfWcbmUvrhW81szabxtXLX4MrgSft+Zf+B\\\\\\\\\\\\\\\/ZzbxRaFDu9gAl53\\\\\\\\\\\\\\\/BErZZRLIqXT6YMTgT33XoILLUVcgFqfoVXZwZ\\\\\\\\\\\\\\\/JXDTf3Q11nm\\\\\\\\\\\\\\\/+YWqfB6vX4V6RD6jWMLeCz7k=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00220+k0oXcNb6IyTUZhujVhDQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fad980b99655fdb7802d1fbd7f1997a6097f7fdd9e767d36cf1e3057adb50646\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A263.2.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A263.2.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0433\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0433\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-SITC2020.0433\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}