{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Dfu6WiZ65IjRsHaeGbh0so6TrlAca4VnWTaa2CPMiS2t3yo+ypdpfO9pumXeo5nTAvB6Bx\\\\\\\\\\\\\\\/wzin++ehEm9ijoHQyrKsk1e\\\\\\\\\\\\\\\/ROZ6VVIH0tTTuz4mtPpCW3yn3vkkMdBvoQzs2aYAOFGktNqjrBTf1ut6HXvDSg3CBWTPvMcEwvs3y7idrBzHbJ+ArFnzaiccttA9bcUZmlltiT9gRZkIy3nUx2JMyym\\\\\\\\\\\\\\\/tuVRp1c7i1abqTvjs6pujsyudn3bIkB4X2FtbWQs\\\\\\\\\\\\\\\/gcwZhz6Mwxs5yglgbdq2bkKbR+V7VGVfBq7+EJ7uCCNRDpcbgA+u639tyrB85Y+GBuSv68ECtPK4hLHgpV4gxAJM4iDN2dxDjKxO5vIejutCWEIKv9kW5DknRsTri7uBDjRXLNc9jsEKP7zjpz\\\\\\\\\\\\\\\/s6KN7X1YwCGZ0PAHOJAFTJWCNdwA3B6oVniWhYBeys+dhPIni01zzmBVQtlVvd5Ij\\\\\\\\\\\\\\\/Sd1Eg36rkSM9uZxVIXFPwkoLVK7LoKvyf\\\\\\\\\\\\\\\/NncgcyG6UPZk8nt7vCPNMuYvxMyYKW1NuxOOiej1bSaZQhRfJIBAjIZuK61tD7r0Nne+x9YTl8IZ1+jRrat11mqbzUTyEE22RW+48QehhCfCwdvtlj8zBgrqP0setSa4Xkjt9yTnZfuoIgaEVsGHLNXGULN6ysHVIbLc25U3TKL3va1Rq0fIjkLCPPBxR8VX6e8HdFyssm3ou37LCsvqif4rCYdOyoKwgmwYowTtGwWbmheV39iIpualLf36P+fPgtxoahIHTUolV\\\\\\\\\\\\\\\/lPj3unAgghdnuJLSU5IF8xpZnfOIJ\\\\\\\\\\\\\\\/iT45jDzAkUeCVOFaR0NPor6aIVuVjMekG\\\\\\\\\\\\\\\/aJJFEzuwKhO52fvadzqpUe6fqdb0N5Lewd5i9QcRqTXlTuV30NI\\\\\\\\\\\\\\\/i7y\\\\\\\\\\\\\\\/BpEAn+OVZG2tInBR2YqAEOwoYUGo5Wa6XjKhY8l1Q5j4mREVLO6rqVTp2uz5LmdV0WOe9\\\\\\\\\\\\\\\/TXDon1c8ff6IrLPZuWaw+HIO7K6MiHHEhcwQECyAoqd7+DVVK62qrnCcfPNuQXmTaPy2BIE5wsapqfqcFJjqzIDklIF9OByzCMtuq9HbZ1m6AFoxw03MfNeCvdl91ADeeVvb2sTBufmwToiWyNd7D+Wotkc6KkNOVn12Lxdpgcka9EDx7+0q7tJdJfEeEaPrGJwlu2PqdggLbLzn\\\\\\\\\\\\\\\/yQBIa19pn5vKgd4gP+yp94Le27qJpu+yWqnenFxfrS6xAEH9oj8WtTyRd8hC\\\\\\\\\\\\\\\/WpYMeq9gHY7A096uglyIZvX3LLKGPUN4A77s3Y1UUYLRfkRNeZPUQAjdS+R7JFt8W8W1S3wf3cwZxj\\\\\\\\\\\\\\\/DfNq3iRor59Q3NbF4OeTKggYE0UI1nB2tVuqaWkSLaZbxfusP5DzZU1UgNo7tWAAaExNBt9av3YEf+jpailF7arGdeJEc+z5mBMh+6JH+M724Uc2J\\\\\\\\\\\\\\\/eiaXd2HIUs4KPbdGiSCzrWtGmrx8yz5EqFx15yUcwu83kgiN7l83dTmPkAcUr26bi4YF\\\\\\\\\\\\\\\/6gCkNmxZY2FIvI6jncu\\\\\\\\\\\\\\\/3UUdJYyGPNtnBQsrCWM7yZUEbs3uakV0+EWmtuR4EFN7fP4\\\\\\\\\\\\\\\/wu4OpsrKP\\\\\\\\\\\\\\\/RAOMDJlU3KHxZ4g3l7MiBmraN6REUj+xTwH9gcu6IQs4bmkPzmqzjPC9IRdLiMhCaPx83C7nU2RVz+4coEGU1yjzdwg3n62YLQes06ljGxBXRNZI6J9G316KmMeav7+0Cj7zOw05kKQiCZmDCqCdZxctNK0r8jSviXtPMW2TvzHFBMP7xTN9ITuF268Pv6B75LNg24gxRhMgeQgm2OMzikEAL82GYamZ60Ewub\\\\\\\\\\\\\\\/8\\\\\\\\\\\\\\\/QIqHwxQck2n6dos\\\\\\\\\\\\\\\/2oy0P6GGG6Unu0OHAi71ynfK6jCmqsvfStnKJ3gugjKY37WscDJzRzY5JdDNs4REa\\\\\\\\\\\\\\\/222etJ4D8mZc8ZzK3iPict0LQg2lf5jsSI4iizd532jQPWQXWa4v7QmM34vDuZ9vOP9U5FBL5erbQJa4tCMl\\\\\\\\\\\\\\\/lcu6C+cdhn6hr\\\\\\\\\\\\\\\/e57CcmBiar2+\\\\\\\\\\\\\\\/Dnk1SlfyA02IdXGM\\\\\\\\\\\\\\\/oGBZFfTgHLI7CiUbV8Nsr17AjRUVrHeE3FRZj+2iBjXKDmmOEO7qFb4fEmlQhBjCMLi6e0OYc6Tkho0n20v42FrgCW+4QSlNIzT6EKKek5cDx++PoidP4FE6mynwrfowMist7eguXyxRnvcTwLv0wn+pw\\\\\\\\\\\\\\\/2+TaHlUSechkLJq0UnHZvLPrOpN1fwhz0KH9jeVFVxYAEbuFyFZuuVT+V\\\\\\\\\\\\\\\/LU2eUvng2tgv3PQeeI1i2fjxxaDg2UJwhKH5nMVkPmKmdrjOOwk1dASVpLvDUxBNjZM5uYpXsC8VK\\\\\\\\\\\\\\\/YNZ0+Leov5c7v0N1a\\\\\\\\\\\\\\\/Nro2ZOOiBtOzCyRrPJTj71Opb6B8i8pbhVsdoREGLNNrwvlXrxVuUZExBvpqs53pDovRyEvGOFph3NRuauo4xlOwyg5LSL6xR82ZKDOC0Y8LdWe4QEUqL7UKKQZWaSAuRTiLTuHe96hQrofq3nwJGeJZydaav5lgbm8IMc5fyegrwinySA+wdCKZ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/JUUevksW6RdE4ML\\\\\\\\\\\\\\\/d+EEOxUeCz4zsPKCJBYrM8dKo+moz5GDqF+f\\\\\\\\\\\\\\\/q5GowDa624UeL0eRJWdcO3HuDSPQkRo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022CmFkpkW78xk\\\\\\\\\\\\\\\/1nnKlsQaGg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002213a2cdfa6aca42f4ceb9355f172d311c031c695572e62d86d20d0cde94a2bc6d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e000331corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e000331corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;8\\\/2\\\/e000331corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000331corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000331corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000331corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}