{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022iE+NAiiM4IEGtCYC81+xSqDGligmSBuHLseZ+omXLqIDlBZfQlxYYXl1pczzdzjHetgLjCOLq8\\\\\\\\\\\\\\\/QAImGA0IalidfdsLNpoPQlxSidNauB14dByQYH+6paiCjAOxG7KPywpANO6Xh+Omqzvvjj2KJvc+BmFYK3L511KQE0uaoUe60qJ6bWef\\\\\\\\\\\\\\\/tzbEX6D6hUCehoRS\\\\\\\\\\\\\\\/SXbasEknbPwG8aeR6UAeCJ+SdbCcwCaCdyDGv\\\\\\\\\\\\\\\/Pc7GHfSfhDve1yIE9zFr4VSVAa2nHHHeekWT2JuE5Ct2LqhIbLv7G\\\\\\\\\\\\\\\/FfxtWUAfsPU1pFhzAVh2cBwUg5cGwdMYhRTESVPgUwHnsrfq4gfJ+FzBp8R51T1oaEdU8jjAe9nOqFKvzOHmIyoNsRSo3ohwtFusGYB\\\\\\\\\\\\\\\/CbR5B256zPPDhqTP2xNn8xHP\\\\\\\\\\\\\\\/Ji\\\\\\\\\\\\\\\/dqjmuvIS+pMbkbtSTX4U9gs769h\\\\\\\\\\\\\\\/RN\\\\\\\\\\\\\\\/H6s\\\\\\\\\\\\\\\/GAGUG9ptDxfv30AMMEmh9sCXDgY1AFSnwu76i7Fn8bGnIIMpM95Blq9yVreiJ5cR+CDvWiRqOGjAgmgA39Kjm5AQI8AUcWVAjRVEpiqsUXm8tVI8eSMGBGlHbXfcgXxj6jLJiKY+HUG+kGjss3+zGyBgVbhvarI3H9h2\\\\\\\\\\\\\\\/B1I47lIbOdYFjvCL\\\\\\\\\\\\\\\/p\\\\\\\\\\\\\\\/PORXAbEkQZsVC4rqwR5Zv6dfd699aIvyRC+zl9ZAato+dLNtrY2ObdPm3NJpb94DJvH\\\\\\\\\\\\\\\/YGtCPM0aD73Xa3+EPkID0VTzUPIidsiQ9KMEQgqTh3RR3eYG19b7NyM3Hw9eFQVOc+RC1mLzUYQeNy8Ep8FnBgu9n1emgkYvXrl\\\\\\\\\\\\\\\/Z6+xIeJc2OtRLcdFDnSH98bXr4ytb5W1+txoLnfwqAMI0GFcfH50MacG+YLf4\\\\\\\\\\\\\\\/7Zdf1\\\\\\\\\\\\\\\/5Cf5LLgHN\\\\\\\\\\\\\\\/jkHv8OEPgX1IPE4QXC5ARUC8JuOQmdZEHk765Ak+1KRkSC1oqfkvf8ShO4zZ\\\\\\\\\\\\\\\/MMyH52POptvVyTEjmarYpEIp8WZiBRW80aIlm6zSkQ7UaHB8iL1a1ms5FWzbDhF7GQp2IyzAPqWKmNXqyQtcvFuleh\\\\\\\\\\\\\\\/XmsizkZruU2HfIUZ0SnK9silyFVn9feS\\\\\\\\\\\\\\\/k+EeWrQFqO93eBmVGEBv\\\\\\\\\\\\\\\/2958KFG0VbTNTx0F9Ct0dGr8SMWO6\\\\\\\\\\\\\\\/FAPEGL8iYLFZCg6IjT5XJY83Ywj1tmE06In4h6iCd8Cxy06tGTA\\\\\\\\\\\\\\\/6ZcgZifNQ5i+l3kCRFgXpf+PIMfy\\\\\\\\\\\\\\\/IAsinANrM1BP2lRifUICjzAAyjEqpFT4XnVRkzg4OWdAmcuoKIghDl88R12SThkkpTga1yfVoYIjvhwKcBKccinC9Pd6WvTLOIHh8joRzdJJ18GL7XrYc51VqB9i7NjhEVwhrw2Bdz75ka6u2ZgKriFh3zhdFryMAvpr5FLqu0CUfGDfhVa9WylJ9mIca8N7mVgpd4uNiROjDw8DUgzc7QbU+lZfG2qEMwu1fcEaC2LtKwe6rHldtLTV44hwNy\\\\\\\\\\\\\\\/wVBCvQZTbcanF+JgaWfP1RNhFuSUMLXG9JBGQgLbrvYSQh1hkIuk\\\\\\\\\\\\\\\/8vGPsuV+2G1Af0E1Z3LHCK29JaWQxTNBBFHWZQJYK4gX3V179aoRteeXKeEEyUS+8KC7rJktqme0IuzOK9JiUFwL7F6N4Uoj7H4JsSw9tf9FrAQPVfjq4z1qtmYUwErRwImpi3LnJcDnEEEg8avJvYbvCS9hY62nF+D1MMuy6rA+TbZLhbA16rTPRP\\\\\\\\\\\\\\\/aK1OVTlr+wscIRe9jPuuXsjC4b8ce6OOh6GtWmBXG7\\\\\\\\\\\\\\\/i85HamTOGY3xKlDfSEdyOtFh8TkLtpGRq4IwWYBYH3veg6a5EcBTY9hu0raZogAKGz0oKRrx0evpz\\\\\\\\\\\\\\\/AuRh6GNXfQkzsXePETUHqSrwjc68PzHpUXrnekjFvJPpfDcL2b2wWzk\\\\\\\\\\\\\\\/tCoGL8IlEqoA54+gbMr3\\\\\\\\\\\\\\\/EMF6HNjMTzdYBgPNuumtLbHGjwg1jlLCSNezgBaVSZYbilYCOFgeAY5vKq9ECf0RgENXYWEsTwUwmM6hcpxr7tIsRFHrGszhBlKG+Ki8rV4atV8G21YW1MQbxSSDUAVE23+exeY6g\\\\\\\\\\\\\\\/0DAKfwEfXY8KmRwwWUBnEmUU6AfdKbinUQv6dKE81oVdvUTDvFfALIFy+VEHkXm0xCZ7CyaYnEEvLV\\\\\\\\\\\\\\\/o72uAhHeQV7vSjdQ9Gfd8d6FE42r8wBvXGYgR11ssBJaL7nSOJHYEvAQCJRXHHWfDVRFqne8vzofEOteGPw4g+iUsXgxyfF75NlJVF9iOKbi6ctVxWbjA\\\\\\\\\\\\\\\/vc5wMHp1akz9Ij4ElsOsdA5RBAiDGI+j4QWONt8EJPMxyYOt96D4LllsSTmlJBuSirFYvS7Dl0HVGEy6H4qO\\\\\\\\\\\\\\\/cABEV46nl\\\\\\\\\\\\\\\/AztHMf13Ag7FUTghVAOCW1x82i8q7SU6fuWe2vLgbmez54Cde1WVYawd0g1TmqeMVK8wwNjd+ngbraR8PFJdEpVWKx34J6eaWgv\\\\\\\\\\\\\\\/d0+PAIiumC4hmqHd8kwdbR0zDhqERLVxdm\\\\\\\\\\\\\\\/JuKk2eSA4Ybq9BKxHD7B4p6btkm1S706sJMp3WSRbn7VFnUgbOcUoYKKwY4\\\\\\\\\\\\\\\/FxkOALdqo+sTrcpez5xtw0rgCmN1lLweZqwhZx3KiePtiwSJyLaN3W0p\\\\\\\\\\\\\\\/9qhYEEUioXOECmQPkvWJg4dZA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022UL6NaQtM\\\\\\\\\\\\\\\/35D\\\\\\\\\\\\\\\/3jDfvgxMg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221c697bd18ab7f3717d2cdc0067345e8fccc72d7cb22eee1289acc43e6ae5f03d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e001156.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e001156.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001156\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001156\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001156\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}