{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022q+uWeyiHz1q9TtC24UmIMr4g\\\\\\\\\\\\\\\/Kkvay6B0zNyXN4G6m+wNgsqG49Wgd5gA+XZTyAEHGGTpSfE2xbri3QGnXVRyoQLWM54994AqnGnDBjEZKfMSaiV1HXZ7p6rkZCkzOwi7US6krfK73dXA9H95BJ\\\\\\\\\\\\\\\/SprY7dBCh113sSv6nE5+Ngd9nOF8dbBPCkHYHzcVAMoF4izKxu5POeZhMXCOlJdtebQKi8hyYppLDU97T2fUUzPxxg\\\\\\\\\\\\\\\/e9+ENk2gfdp+9A0UW95R5Lhu1u30qhpUtm2mt6LKZWv+uwKbdmtflm2qeE5knxvkx3l+OdBb4vbETIEOKZBTtakbSyGFz+QGsSDIQy24zzDS6lmOp4H9sXE8Fzobx\\\\\\\\\\\\\\\/VuJMg1QpoypotoU\\\\\\\\\\\\\\\/bvbRYyircwfzK2WFB4S38sjdTx6sYbHu3Ap4R7MJnrqk9fGiai07m\\\\\\\\\\\\\\\/ska9htNwLI4B2f7N910yPn1JYxfD\\\\\\\\\\\\\\\/KyF5Q9Xi76+UTesERCtBiNNc28Q3hl2joyeGjCaCQBEiaXfWMmYzF43BYtCUQkMucI5beN8PskF0zMKsbsUavtKErRgLlD6cKADq3ZN\\\\\\\\\\\\\\\/6xzLLcl9JwdcAlwSTtnRRnJVKBl\\\\\\\\\\\\\\\/Ng\\\\\\\\\\\\\\\/t3ewzYaKp4lFtP9\\\\\\\\\\\\\\\/1Op+QD0\\\\\\\\\\\\\\\/TPlz5bXt5DGynoEROYAva17s1gP0fBWqaRg4dZ5SQYcdocFqQ6irWRZYks4V5uhSd4EVK8sDOcFYnmOFh9r7SdwYBSZhqUDrYdDO4TJCTdaRfTzV30iGxFEsEItgHarHz11mKhHPv82sGs\\\\\\\\\\\\\\\/jimNTpRN1LatdlOmAecbKh7HJXjy7rCJPhACzWtrj8OlOApDeeNJDVAodnO74oBbrTkfi8izlbv0ihc+T4u+kZwgZMZDNf3HoUdXoZi9MNpK6T4YY\\\\\\\\\\\\\\\/Sss8w0i0Eswdj9TkHq5QkAxt4d0wYztU2SyvzRfmzc8rTpQbNP9Wh6WvCWOzm3RvHm+weOeHvR3k\\\\\\\\\\\\\\\/dr3wcGu2ULLMoZoGXD7KXK0L+qWXsiQk4AYMNZdsy0f\\\\\\\\\\\\\\\/y5k86b3BOo4WqU9EhsbVAzSrSetZmlHc0gBfY6DjLlUoiMvMMa\\\\\\\\\\\\\\\/Q3eI5HV6CgLi9wYZrFm7ij\\\\\\\\\\\\\\\/QxH3\\\\\\\\\\\\\\\/bO9FANWstUCvsTf5EbFCd0kY45eAU9YdVYP7F8tR3M+6A7gOl+pfMNnrlcDelyLawaHDls+Y0vc6GtcFNo3SeCohxJCDgTnwsC336ECJZiQVROXnlGC1L+UA0imG6kJ32g7hZYqHxMeiTMwan\\\\\\\\\\\\\\\/8zv4MMpZU+uSLXILXe8Wanx8hWEOe8sKe5SCcFXF98RwAISMz1q41ZnO3G+OOPa2bfQ4zIWJ\\\\\\\\\\\\\\\/MzHE5Dgu8Kwom3yRiaoXxdTyBNQn+WVpcdLIV\\\\\\\\\\\\\\\/1qbW5xylcv0yCWhR1GKpHhopkaQ7yWWUzntnJz3j66jEUiM5c\\\\\\\\\\\\\\\/MxnKKVVTKXeyvvIy1yhx8G7sqZt\\\\\\\\\\\\\\\/CemL1e2xAcSSLi0i8NXvtsaMS+AAydIau07k8MGpAlKLu3jx7afjrkaXrhNcuAwNX4eAZ8WxtiqeTCPxJZX6pKLvplkGWYat8aD9W4IxoAfwwUOKIl+DyEagDxI6Dyrs3gAHS9eIIRCxDofkdjRQzdkACKotxnjMERtf+4iJFaXzrhR61eCgbn+8oLZlc3tJh9yOAx6SDGOHTq+EU5yBG1wbkCB7mdLZbxliNOPTq54r+\\\\\\\\\\\\\\\/Sj5XnaPPDzxvPXUQ3o7dN94Tg3EP2oJOQurGJ5HStxnz2ocThYKlYmK2joWXaGoJ7z9GyCZ8M3f64KX4gZCcUAEMjkwToBn84e+p5X2qoaFofSExWg4s7wgcGAkA6xHrjxA2mL3gEAVhT2qAU0Gj+dQkw\\\\\\\\\\\\\\\/G\\\\\\\\\\\\\\\/WzTDpgybElAn6Zi5MIg3PNURS0b5tspvmjVLXjWkYocgln7CadwIs4yePJAbI3PeqjrPUbUCQiKlz1DXk9c9E09xdQ8j68Axa22htwPru2dA\\\\\\\\\\\\\\\/sXsRKoBSMeDTp5vOuWueKsYGuocBknE4cqDVi2CkAGO7xx1RSZGNuflyKuGQXXca12OakU7CsS5SylLyNEQo5AsY6v6Q+kxL4JHCTdiOqGOiI+9\\\\\\\\\\\\\\\/ru9DEM2w92nzR7DnYfhuDwWKzRBAPq7qKXHOFbHevEqfzwGrJk+2S\\\\\\\\\\\\\\\/Qr2A30vrTCkkBra3RG\\\\\\\\\\\\\\\/NmouR9+379mDj4bO0PeZcYRPQAoT9MyJ1TmSZjs8XyrKApF4jOtXKFqehwsffdG2GI9cEewng9ZNNm2LYc40zM6QowHq2j8ja+gRJflGtv+U0Kx8sgCwQA\\\\\\\\\\\\\\\/2lGn90pviBSPvV3T5B+1hHW6sdtSizhcZcYyvN9URIYxvGCP4ikUc0VLcCQQFTp3E3VaOyyCfFi2U95Py\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/4brSPSdmd9qjZhNtkavMHhukicv7ccx4vD\\\\\\\\\\\\\\\/ytvvt4\\\\\\\\\\\\\\\/8XpRF6cw5hXEO1+HYAQ5VpuJztyHpIW\\\\\\\\\\\\\\\/DINRdOz3Y23DimEFT+r2ovdPx1xURkhO747cZcWB0n+aJFn2e12yp4D3U0v+yVnsGQgCAyPXuV9WpbM3ddsT0LNSRy2Qe3koVmggybycPnouXH75SonB41fJ2muyTHy56kqHXcjAvEmNJ5qBv6E3KCQ5+y\\\\\\\\\\\\\\\/ARxlZdy9vUgB6ETWHpwJdoQAkKgilEnkBnJlTrI7hTpLt\\\\\\\\\\\\\\\/1AztgSf8K+yawUWA3AIztik=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022n4q1IW\\\\\\\\\\\\\\\/gzt44B46JeYF3gQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ca47888b242d13e053d2b409ff02264e0344c32c7d9ad99d4e6e5bd720959804\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e001361.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e001361.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001361\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001361\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001361\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}