{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022i1pPOaIGkb\\\\\\\\\\\\\\\/X8PqwQONlPGO3ZSgFKq71ACxXrklNVw3bh0IeG3kPg8XU3L2YvEEu7gmghpIL1dNl+Q4izqINy3\\\\\\\\\\\\\\\/PPdYL0Ly5ZwJzF\\\\\\\\\\\\\\\/Cd3m4rLG14vMg1a5KWXD81F1tBr4bruWDJg7dVZv3Vsqnx2IsXMt0LKZVfbtsnWNR65+vmTIgCSNQIRpk5IGFM0H+ufGqdZMX8l58px2CaiCskRsn5PcIcf27dFBT2\\\\\\\\\\\\\\\/ZLAb9hYkT9g54ht0fqlDWDiPlJBXJ6jkOq57SBqPAf9E2mVZDsrmjMP\\\\\\\\\\\\\\\/V4+XrVREvidVJVE9TudTvQ4qQv3TFAH35MOd1KaBM97csnY4Y8hOgj2uxRpOWXKZR0opKjsDGpVhfNLcb5yvd3g8uCjqFdjApARCDMr8bGzfGH8Xk3w0u725Ra5mcAMROATPEop6G+gnUnospqtb6D8LKu7TqPz3hJMRaLPMAMe4S8cR6dDkvapdb9+LJJOp96u8MMwkpqNsVVABE7ueGQ6os2\\\\\\\\\\\\\\\/EBWttwc96CDlXg8WB2RDd1Xw3DcSguZBpChPxdmL6M+aKor3wOl1byw03NRXCsamsCdzkapQ9dqwwwDmmZPlcqUCnJbkrqcI0HFO\\\\\\\\\\\\\\\/qD1q1KfatR3T1i9i5mt8odjFQ3\\\\\\\\\\\\\\\/FZFHLEkRIjnNlbXEpU9sk5SGVwVg8ZJlsOKSqr\\\\\\\\\\\\\\\/tgWyRFX+iZ195VCmLdWOdWsEOQkSF6X2vpVhKrRQOlrIiNLMy5CJoVuYAdycu3EJXrsqNv5cPHUTh+eckSNYvbZX+YzZVJckfQ+aZXJ9iTFEucFxeVJsDczSYFb1B+wmAPRkZEHDZkPs3jdO8pQ4DP\\\\\\\\\\\\\\\/l4y5XtUd\\\\\\\\\\\\\\\/pxCvMhB1cmvpj4Mjjy+mYIcIzCuT0IuhK6am4WxklBCO+2df6kxkFc2iMsch4n\\\\\\\\\\\\\\\/UIfdZsFOkXKfNEQyQNo0W6QRbA2ih5sV+SbtX+cPJ5RVtC89ZjJB6pyT9Jo\\\\\\\\\\\\\\\/U3EJqXuZKHsvCvLnM56U+cEq1UYRUcq1yaE04vAN9tZaid2gKg2bIQ6H1Bens\\\\\\\\\\\\\\\/quifyoYbHYACtDupoK78wDZl7YfOlvsA5bj8CPKzOTATlX1PVZNp2KjD05qoXFwVErvWy81Sa+XqvEopiMSLrf4SL7arNMrTQa5ClUC0wdHniZdUfPwj7U6TiBHOeDd\\\\\\\\\\\\\\\/CMJLsPV7mdf14Zo3Opx34LO3M97H\\\\\\\\\\\\\\\/Jc1\\\\\\\\\\\\\\\/uSb15aXwx0R2PQwpy54gXQv23Z6y8IfoCPxqxBDrXKudKQe9c9cYKv8RUHiMzfodIyA7ttTVizr7kLKB\\\\\\\\\\\\\\\/fH12pKbtzJqMiRu\\\\\\\\\\\\\\\/Oo6fVhymBXt335pPuaOpfdvkV3SMIc0+ciBT\\\\\\\\\\\\\\\/nn36MnE2OKmTyYgyAX0mvcuuOyzgUzkS2yHCMw6tvsSN0X0HXlvkc3Wx1sSysArOJz05YDl8\\\\\\\\\\\\\\\/t5tTdWPIRNqsNpwS+ar8n3UzU\\\\\\\\\\\\\\\/d\\\\\\\\\\\\\\\/NZuXZFReOFNxaxJm4syIpadaB6OwXy9BmYctTCAVwt17JbTQ21SXEZhndBDF2AUXL4Ni4B4LRdeLVR57hz8M2NMjB22yzphsbHQG3TiBGuokTONQS+9qO+KWFP58kpECoIPs4RJD8fZzzoE4lnLq3AvK4v5WCIAtBvUhYC1lJsZTKSagsP3PdXxKuS67v0pA2aaVJEH6N4krho1m9CAa0fDvYgB6hA76xJITI8e4WtlfDq41vkbeTP4yfL2X6BVRLUddk7dllqg80BB4pxlEgyeoZujo9QwdH06PiRzw\\\\\\\\\\\\\\\/WqmeI74V+dpZ0l3vmBSdq5NI4Ug3m2cq0rmVVap99eGoYXIu4ACH8wph7ERhfDbwrBcTws\\\\\\\\\\\\\\\/VT3GOtnGWsSl5CNUt9qIau2q5bXjP4jAz7tDwSuG4lkC\\\\\\\\\\\\\\\/vx+7O4Btzrna4Sl9n6D7brYvEzBNg+Al+hy+Wzw8E5DacgMcZwWhK+4L92x05VmVObHkDhFzkSouIwZ\\\\\\\\\\\\\\\/bz5nvwL7t10jam6GeAJ7pVndoVGhl5gr7JGMD6hIbN1ss6XY15yO4NqK\\\\\\\\\\\\\\\/DhnicWH8xJfN1JtNjdrJ4PhIj2X7GjqkJcyzddWWfneDlBUq8OhhbTKZxmThTrclWgVvzLvRoDPQIiXkFohzr4TVVjedMPl73GoNoVGR\\\\\\\\\\\\\\\/Y0Rz7mkGv0vgGbjdoU928IrNuj6lgex+ieBxIIhJ5CwMf84TVoDVmlgVJcApFoW2dTv2NwtiCUFo53sQMS4w0AWqlvAKBu1PssehF7zdVqXR6mqWLB4IZtS1eTxA5cfuXnLoMR5H682tKwv3aeRwPY5kJpa9TC5OBVrumS+nKpFuaXVfKauNm2A7isg0en1CE3FckF2hBFwxuAbtCP4YgojMPMN0sKHU7bDBjTbNOvWWtoqt2yd+Tyrw4aEpmtxB+GftLnSyWalfB6kN6kFMK6la5heNnbZAFEMGAZ5HOScmx13kvYnZFomCqYrWRCcAbDRj8WFoazYO7mqgc8i7HyPAHL1yWaENKRhMc9rWN3AsvWS96c2uRBnvpzcYhodFpJZ3\\\\\\\\\\\\\\\/zyGheIdP\\\\\\\\\\\\\\\/8nrXorpmTwmyvbWPSbt+8bv+mhrMJqwJe0LaeP8op0N\\\\\\\\\\\\\\\/tdEDhQLM55j3FkZDfQoJPcHdyxYvA8heGGIMYXVBpx3lenuS93LlxydPIO+r+P+c3l8P\\\\\\\\\\\\\\\/tGbR0T\\\\\\\\\\\\\\\/zAh\\\\\\\\\\\\\\\/mnxYueovwxcq3w=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022iDUzA1Xsdm6EAWke2Oi2Sw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002268ceb04473a01fff54a2dc685b1c581ddb5ebd1ffdfcc7f52d83b97788bb44ca\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A335.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A335.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0553\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0553\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-SITC2020.0553\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}