{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022g6VUBYXdmzv6xVbJi54lZuCR27OaIj8jutx4O5fUtpfSitcUW9CWn\\\\\\\\\\\\\\\/Yby2dpKpoDzeKrKtoTGYwYmmJieWXGio2j+8+DOOyZ9labcFKRQPeaOHY6bEsJua7t8PJh7v\\\\\\\\\\\\\\\/lB6g5NRvAUOkaTX8mCZTdiGA\\\\\\\\\\\\\\\/cZJ4nkf5spKXr1af3f\\\\\\\\\\\\\\\/CT3UOg+yN6zK7KxLIxvkL1dy90DPsvkr7I3yH\\\\\\\\\\\\\\\/6AjQ+1teD7OSKjjzoVYem2Q8g6d1JFY\\\\\\\\\\\\\\\/t91iAWba7VBQzPxhZ2OqQI+Tv+irwcuOimzVb4sVvHoE5EjwLcHJMUtgMIRL\\\\\\\\\\\\\\\/DPTrynvbSrx9Lzy4F39Xn+gVJzcSa5KUYAeCy+en61wvY7\\\\\\\\\\\\\\\/25GMDatRWmUmnw3M5GyXCWzPum52r0NcpYSj2CMAc+YeuNIbd1b07Tl0FUaVwmgXhCD\\\\\\\\\\\\\\\/YAjgIWutwMtOOQKsrYY3ZGlMUtPI5SVyl8\\\\\\\\\\\\\\\/CyxqrmKc4lxJCLKwO3TOJordkxEff4FdzqQhL7ZGP9Mm89YvCmvjIEjui9m\\\\\\\\\\\\\\\/x1QWtQL93jPu9d72NHw+7k770sA57SUmx5cLkQ+JOBFcK2xp\\\\\\\\\\\\\\\/oQyiV9829wKo0tPmbpVMxKszKn5T2RPYZ2DjNl\\\\\\\\\\\\\\\/hyM8og\\\\\\\\\\\\\\\/tf8YFXTNfgEptr2yY3P+Az446QYmkAAnSc4YvjW7OVyIZBAMd9Ig1xAqCfQyoWcKIeL6TwK6j\\\\\\\\\\\\\\\/nKKEkAYfgQDKrvm33tvQC8wUROTpG1oydOPFLt1LqiCyVvFjL3umkBi8vSKkV7VvFvg+JPRVvWWvuyceecIHmUlhhQORSfYt6uTe3nPCc\\\\\\\\\\\\\\\/agYKXylnl3exeQSJQaBwmmHKHJcB\\\\\\\\\\\\\\\/zbf3E7cSMYmHGajMLkEE\\\\\\\\\\\\\\\/eJ8Qq9uS3NW\\\\\\\\\\\\\\\/ehCSQFpdLYcWaqE3ByjZOI1JPzBTw+ogVrZ43oa1LmylXq3vdBAKy6vkbJsUX1t3CZy41tqnQjOfFjW5MXQhgIDGWdljEPzeYRjnxk9DD547p3PpzQkGOoAMdBBJ0svrThY+0Ji\\\\\\\\\\\\\\\/IYVzywF693LVkcXM9Sr2qLjyzmTU0uynKbRxUTZQqzf+MJMrqji9CziBLY+MhRgV+nwVu76prWZJH065wWxuh13BX1oMr\\\\\\\\\\\\\\\/vjbfSKA5cP2GFzipyHUyntuPVAIqKiEThOa2tDK6H7ybrjaWZLCAIRRbSGu5WU7WcYqsEvF0M3z7Q3lGcdkWdEsJ8Yy1ojSvAurM9L+91tnpN2UFSXglC7DGR+JN0TpqvwYy+ck9ucYUynvCadbc6aG1VaVrwaAXxAZZH8qeK3jMUPOI8+nLAC2QTQM+VsXcvtmfYC6zETJtQk0soS66vJ6FvoFZqieRa4Y9u5thSjieCuk2xyWB4WCvbgXgsFg8\\\\\\\\\\\\\\\/pOwhAKWGoSwrB9aH30OIFcpNjWpAt3+9klHikPxDVxkiCHhEKQOtfk\\\\\\\\\\\\\\\/x3o+RiI7PrNPRmUcNuB+A47cs2LLf2IeH\\\\\\\\\\\\\\\/hRYrF75+6qDPzrl1+FjVmo3YJWzX6fqYWSvTpHLgRIejexuYdWTCFr\\\\\\\\\\\\\\\/K6RX4ApOAhvOpYIPIkCoKq\\\\\\\\\\\\\\\/nAHrVs0HEbr3XEcqKocYHMQviAm9pqh08dYO90xwIdxwErdVx1+6Y6BIIFML3VXSd\\\\\\\\\\\\\\\/NS1j3Kw4nclWWbz5QIggZYY6K+mHCrnio1SdD+ubvX4v+abcxhENRTOxceyyf7R+qakNVAlEhMczKGVUcXpaqk1ApnqC2X8MXWFdqKvlyrA1ct3AHfsfy\\\\\\\\\\\\\\\/uTGt\\\\\\\\\\\\\\\/frJ7BZF74uLQo447KF56Yy61yeUrn67D5gh\\\\\\\\\\\\\\\/T9jPHipLU4tkgi0Ao6hDwq8nvMm5jmYUwLtAIWUcZ7m6zDxK75MIdwW1HVproKy3Ds36E2OlczdBjdmsYUio6m00vB4C0x1yu89Y5e8FPADpQyC1bVkBpdjGGclbS+cMhq07GnxHvkX6XZdb1jSC\\\\\\\\\\\\\\\/Vp6lMXYh51K6lSp6K\\\\\\\\\\\\\\\/36vLBueTOZ9hY5Wi6oAThKpGkujn7vy\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/L2AicKsYY7KBR3tFmzkwPwqxuKLl0mDk3DroL3LfH0KAFGo6uOUkZyBOS1rRVn7rYkVSrMmbxZfZ24EafoYvrS2DF2DbCRAMUMGfwHfkbIQQe9wZb4OtsufL2n6XwQ9gs6ZyHPiR8ueN63LWqJ8lkC16JTdgEbwImIKhpKOhzZ4WUKIx6cdMkSMNV5hELIA4LKN+nImug5PA0LArXdQk+v5X+2YRfjZHG2EW7thoCnKyQhR9MbUe7MqSUwqePYN4OrhRmdrROLji+g5pLHkD849dmihc8AIpjJIQdhEdSKpe6q2yzsGVxdOts0JcsQr8DfbRSPDv\\\\\\\\\\\\\\\/OfhuRmzc5dbY\\\\\\\\\\\\\\\/ShALe\\\\\\\\\\\\\\\/XJh2zt2QwKdsevfJTT5yMf1lyqdJMGky3LLyfCpTR9E5T7ICtWoTvM30C+aJ2hJ\\\\\\\\\\\\\\\/G1EuwjWuiV9C69AjOUmIj1TkthJ+t2g3fHrs\\\\\\\\\\\\\\\/VK0YEzkBE+JQ9PnO73QDZPn+yUf0aSVtMFGgqEfC4kyo5RJm8l4rmRui2RukOznZuUmPz3AaxWRSBWnLkk6a+uZa1CKwlc0DchfiWQ3iVCfAqMqPl5HKZF\\\\\\\\\\\\\\\/bT\\\\\\\\\\\\\\\/kzuL7uP6f8nImxGyxwMgL79ewe9aXIOjQUQRjAT6FBK64h09TDdTfNJHCGv2xVSo3olJOEUcekjry5fgs71GSWNBY6\\\\\\\\\\\\\\\/spl73vIKFYwgg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022jlOyNY70MXv9MOr0499Zig==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fe87813c52ec9091f8e667ead701a102c47e531a6634f14f48f5f50d29a2ef80\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A456.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A456.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0761\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0761\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-SITC2020.0761\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}