{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022e4Rs2GBZkgE5l08SeCkkpi5GEnOhkT08Z8GhkEseC1i3uEf\\\\\\\\\\\\\\\/BNvFR\\\\\\\\\\\\\\\/NBgL0L5Q78JIJGlhVMy+LTtdYpMDOE4OD48jBMta1eaMFyY7c3g\\\\\\\\\\\\\\\/GV\\\\\\\\\\\\\\\/pz74r3rPmV2xCUV5o3H4yMPC1RT5DudPkP0fTp75Nv0CW7eXgS77f44lVp8WArMT9n4qe3cOWEHZgiGKHVjdvdFoNX++8V9jOfDvdTHtQLoztiKPlASg\\\\\\\\\\\\\\\/VO3DsPYEID6gESBM03ZpIbpwPhiAa\\\\\\\\\\\\\\\/7A3iW4+o+v\\\\\\\\\\\\\\\/X4+wIFkVsxCOlzc58F7l1CG3BL5M1otclJlwNSN2fGe1X0\\\\\\\\\\\\\\\/DgsvwbkChRT37YxxVMduQwDD6b9cICSGCrDeC0WcUiC\\\\\\\\\\\\\\\/t473aviVagcDWJl0itTG3b6vPVvkV+Bis+9+cZ8t3f6dyTD5CqobUPdyG910nPsAIt1PgJaFXnsJUJFgBKLGBiv0vpT+NFvYQVgKbukrr5MuGUt9V96XEYTzxY1NIEl7D9uIWrlr3\\\\\\\\\\\\\\\/Sm53fnauF+mi35JEfs3Qc7zV8ovZmu78mdkd0QjD8D5SZ2ebgtGXceP3En7LaOWcJ52\\\\\\\\\\\\\\\/w2D1QTtz7OcVemBvhXa7ueW0ZRig0w1HucCK+rFAhJn6UAiASmwfPRdkLmeWEQvA48m\\\\\\\\\\\\\\\/Y9BWnVRfD90RltzTx8IIl2hi1al4hfULFCLtgeiKTHX\\\\\\\\\\\\\\\/Ufsmmz6jvfIugqdZulstr7j2MqTuybQ2Z6DFqdt+rCpxFq2h0Z\\\\\\\\\\\\\\\/6PUrfQad1mgYP3oYcPNG9EfpNiYfyd+Q6IoMYeCHZwxN1of9GEwG\\\\\\\\\\\\\\\/rTJpxzHh8uDH\\\\\\\\\\\\\\\/GtMCJrA4Jb6qYjfWMeR9mK58m9A+1uoGMNNeww0t+xhbMlK10URifQL1u6f8aUdQ9XZOoBqBtJ3kGHDrOOo8vGh5V19P90R7R4OJf+WWm8XEbfleN+KPm1qg0LbWmlqqxrmTYc30enij2hOZueSOCJzxyJ24NYWN5GkHrkLgQ3XN8tElgpCZ4Cc2CkJRSGUspagd\\\\\\\\\\\\\\\/xXX1Te4c+JR5jh+mHlOPGBS6OpM\\\\\\\\\\\\\\\/f31cbZm3LkyyCdStRKmJOUoe4nojT\\\\\\\\\\\\\\\/hb3ATPe7lTlZl3YnfrDg8f9eyiNKGkcIRKdwtmAqkpnRG0cG\\\\\\\\\\\\\\\/yZn8c0wVz4f\\\\\\\\\\\\\\\/7YUp\\\\\\\\\\\\\\\/EQMF2ElCPyoazFyxZHrgtyrVSCK9taLeRhNf8Zo+bB7DjS3wAh76ieNT79611MkUXPQdQRXeTLiEMbD9PixdEpzE+YzpUmnAa9nBby0jYysSMGhYBLgvCt7AM1\\\\\\\\\\\\\\\/1FLTUP\\\\\\\\\\\\\\\/eurl3ipLX14K8Iv0hNuTwGEtoDET\\\\\\\\\\\\\\\/7beJzVW7o4y77usGaErRwwBs96ReTuiFSTNeU3qmnc04W8xUETixSai+k14Q+8dNGWNjgRI61axAt4YfCt5zfCDI9mZDJb2WeaCZN0OZbAwG1Rt8sjutc0VKEKf3VtMivplQIKV+7KcOPj4JenZVxF5+EBYEIUlkBa\\\\\\\\\\\\\\\/Rktl4IHfF\\\\\\\\\\\\\\\/uMBWzSq9JQGMeMQo1o5ptzc8\\\\\\\\\\\\\\\/yBShxh2WXZXOAFZys09lKEdsUnvLKzzKIrttIRbppACEVs5m3cYfF6st\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/eAie1p61Mr9E1Ai5JzlkH0otcLRkXZEh+8qfohWPqMrDmdv+KFIMpHUkgXcX87U5Cgyd+6rxDOHYO+P9TIhIhYcZUjJBwftVm34f\\\\\\\\\\\\\\\/dEpKQT8FeNk46GhTGRhx7vKEkiRSWiKCAQJGrDlatgLWJExqeQ68dYhsSsTtSLaV+LxhnTN4n0\\\\\\\\\\\\\\\/90y1jhwctn1m0Vbrhdk4Jk9cbaG+f+iVeDxMXEt0UmWgKziH\\\\\\\\\\\\\\\/EYp\\\\\\\\\\\\\\\/JoQ1yO2JU3AmFV3Acr5F7J0a8jwOH+912iEi+O\\\\\\\\\\\\\\\/QVINs4uSrEuU0RcDxW2us+t5uGQwpmKdBPlLDBs21Fsh+OdS7PZisT1szi0vcQaIbKlFno1w8X1oQn6IqNtmLo21dcl5fn5vM1yyP1w4FSYYuKidYHzuAGL0Jj0fb\\\\\\\\\\\\\\\/c7onBQGhleomxeCWKBkTByZ73VuQZkkbj51fcgumM3jDJI9NxtfRD2EzO51Ptz2wJH\\\\\\\\\\\\\\\/Umcnl19aXCHLhGvg99zqaIM+7\\\\\\\\\\\\\\\/IcN6wuGV4M1W5c7ZshGkHUROGFJH4S9o1MRxjFkVrsBVcxLGjY2bM2xiDSML9zVPBbLJFka8QQXTGYp7ZWeWsLhK9lBE\\\\\\\\\\\\\\\/pmoaBOrxAXak6bGF\\\\\\\\\\\\\\\/hRGjt6U18KR3rUnBrCHwtJfrg51qsw4pfgLnt\\\\\\\\\\\\\\\/JM0KmRVwJ4zMC0oUc8l\\\\\\\\\\\\\\\/Bvu4AklbTWvWrcqJaZlkNibsjIyCD71wAQJEDs7PG4SxE9Z5+krSGhTk5p9Ayy5gEBk3pRa+cs3atn9gG57osLbQYj8CKC4YwJeHz01lTrr5EtukbNggmasuTIisE+bIih29KioWlXCm9\\\\\\\\\\\\\\\/MRACU\\\\\\\\\\\\\\\/3IO0Nbd018erL+qcIWl4Sb5WCIEpvqp\\\\\\\\\\\\\\\/gjLWTZMhCLHObh2d2XDdnyiq2xxCOQEnECkoirxBFTqX193L50cMW06TL9\\\\\\\\\\\\\\\/XIQYeGKcV15GyGYbI0ES6OMBewBUU2mzNgRnb6u74TQuA9Bsx0fUR9d41fq495SM25aKlaVoaOyhA4gIp5VN7Gq98UaEoNrw7tR2uLij5um81wZlgzmUOUAu4tq1yEOomP7g3UbdHVRkp8JicfnkAKYsVlrIi8Sm5pvKIvf\\\\\\\\\\\\\\\/nK9qWLXxLQNE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022U5\\\\\\\\\\\\\\\/pJeHTgFQbTLdbaLndig==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221cc10b1e88475a139b55a6b5d00536a13557be6f9269707afc82d4e07776e512\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A330.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A330.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0543\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0543\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-SITC2020.0543\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}