{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022h8C1su6B8nml4NGwJazMNSsusta+YOs5FHpR3rm6mcgDH1ezOQfhyA3X97xQzAfnigdow1lMJTnqVMQyG\\\\\\\\\\\\\\\/H1GXPXkqhwCuK0cDCrp63cTbyxEheAfizRs+\\\\\\\\\\\\\\\/q3aKKp\\\\\\\\\\\\\\\/U+PH6TE2WJY\\\\\\\\\\\\\\\/AwBZoqYoOJZGcpoieuPN16tIeaGQC3xM3GbR0znj\\\\\\\\\\\\\\\/7VpMYYcR54KBihMUlQE6X\\\\\\\\\\\\\\\/Lw3JRsMrCLHGmLo6QDlrTTMqixweJ8uYB1Ovr342x8waV7b2GNV7yA57QipStT8HtTzqbNnBBqyXrB203tK\\\\\\\\\\\\\\\/vsR4eK\\\\\\\\\\\\\\\/Cx0l+PCP6owSUQK3z4Pzhu4avCnnQYhDVLfIPKa7W91J937aIkkanEgPn1jPVhx5vFrgRbECTHyfJobJDFnCqcNQTs9A7MdSA32+rWx5+TrxVSI6jlR0pUxtxuw0o5vtpyI2N7w8Gn1s7k1GBPR0SRrY98s8U970NDqlP9H5j8qvbWQ9N3dpWRwc+VfMAGBc2LyxM\\\\\\\\\\\\\\\/VZgLic4XZCzG4LkvitPbUiNB+GDbsm8+eK5T\\\\\\\\\\\\\\\/V8qy8PJQ0X3hklThlApnDA+uAra6yUq\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/diXYOzGzlQOU5tfgQsZOhwMEueXdZym1jtktivUyDaDNcWV0YR7ROs66tU8qSraxrPkD2pye9rO4+zi2FAU8DIfNx3YBz5jGggo4uRvsd79lowQcn6m7XiMG6B3A9wjmZ1e7vgz5tOH4gwCfxtGpjoKJoJn7ibP55n+Q07zv45PoLqtuc0jqmE6NMNlr999Xduio2uiav\\\\\\\\\\\\\\\/2KB9uHDUYG4EC+lsJvs9\\\\\\\\\\\\\\\/bUwCzcP7JtzpRT3ikKXwi34Wo9sn\\\\\\\\\\\\\\\/dBQKAngqHPVxlKE6iXIMene7e5YgnqIbzAY9hBVeBYK5eepPIBvoKL63Nox41CpXwdbTcNwTprgdweiL9XL78aq15iIeTsc+9SZDUt2Tvsbrpl+3G5h5oz4\\\\\\\\\\\\\\\/s5urUWHGhY40BCoUl3F8gGmUHPTcrnnvOJZ4wKPlioTXeFwfAVZtAhV1bZQenk8hPg439GZRyYrRM1NlnsjaOUptXq1FCRoL6z6+DXnm\\\\\\\\\\\\\\\/hpBzB4ViqpKaN+oRUQGRtUcc8SNMp+dBfBXd56qAUAz\\\\\\\\\\\\\\\/tJYdGmc8doTaBHPA5OelxMDTCs3XgyuBKSHKDCMFUG4Ca+MKZgFAIeSlMJjALiZfXIraXJfaroELiCT3\\\\\\\\\\\\\\\/yNZ\\\\\\\\\\\\\\\/m2ODXRr62ur8bWmYeivPGPybY6cvIisK0gGJa4ze7GUW5xkbruhyTVFBXZcitVbhPvYYC3PlTnd\\\\\\\\\\\\\\\/iWUQfsIT\\\\\\\\\\\\\\\/+QlRWHsgnr44q+oE1Xgq3wPDmsy6JNc6sYRk7tUqHReplOxjwMite6BSmfxSuV+PJ\\\\\\\\\\\\\\\/hP\\\\\\\\\\\\\\\/YQrVM9I5DIHllbblBssI9SKid659Hrj\\\\\\\\\\\\\\\/yzKyjHtjceamppLYEIXFfXxHwC3tSIDL7dM0n\\\\\\\\\\\\\\\/pj5iJNDQO8Nb17HzzUwrsgB2SzKuxMaDSzCeZneAiQ1kq4PJ6VgvwBc3t4w66xaYxoxd\\\\\\\\\\\\\\\/TX480CFQV\\\\\\\\\\\\\\\/RmdPWf5OVajj2P4x22T2KM6p4r5j6cfiVsvDZOBlN8OqEDcMa+1HgNaVjMIfbxNmwGo50G0+nQmtMjIfDrpcKijPngkx8V7wEVBfaWy4y5CcJ9bGQiPJOToyutWHq1ecLrFaFf6GNO57cWdjWG3BXQzpAZs\\\\\\\\\\\\\\\/J9bISrA+TNdXTNrlEBuUvGTQsJd5RFwal9uqbRyw\\\\\\\\\\\\\\\/hSdDUjAzDh0q7Segzxr0yj9Bu+TU6mYCo4kcJdVz+wiu3yq0qTAW8Lfdcpiu078XuRCH5V3pg2tx2dCQ0Lk6hpCDaRlflZV8IZ+D0MNNINomIXo7StV4+\\\\\\\\\\\\\\\/iSaaXEdMmTN6EZIanzxcRxxBb17S2eiFZlaSVNSAwkBD0ULQkpGyzyOvvAvpS9ufku8A3uc6sY935mxnmosunrkIjKInTGqHhoFJ9iQ3Mk7XgmBEoXtO\\\\\\\\\\\\\\\/VRNn9nkwFMhUtfO3FGambrGney8zPwZwKaEmqnYVRtB3b4eAMaMZY1ArbvQaPELqiMMWaBG5HFg0vbeKtVDNK1+1FmjJR89HiUFsKd0mQ\\\\\\\\\\\\\\\/9kwZ7oTCO9wPyICE\\\\\\\\\\\\\\\/aj46Y7gPZO7mt54chNiRiAFdutVU+iz+bzoYuNth5rPKUewi7XLorCx\\\\\\\\\\\\\\\/v363gtz21PaN\\\\\\\\\\\\\\\/95rqXFeguql8m\\\\\\\\\\\\\\\/b513aeJM\\\\\\\\\\\\\\\/B4HUzDRFBCgtxfp7OeQwjKdA1M\\\\\\\\\\\\\\\/sY8kUKJdQGLE0Ydu8WERgbtTMDcQPeCBwndPxsICnvLeeYzmX\\\\\\\\\\\\\\\/PL5WNrOb7\\\\\\\\\\\\\\\/JnyQ6pjK5vR3jrJceilRU1HhAwoBwCqE+oJJD9oZwdiM4T573PTF8\\\\\\\\\\\\\\\/AKm8AuGF25tCoybuRiUQ3gFmDpmQFVlwkH6hlt+7gNpZfEiKeYoiIWZHOBhs2iIxa2WYFSo7RX+Wv+RHvelSsXLOzKDtgLbg9evSOymC4N0laLGzWdqGCz59LyUs8ecvO24jmb5uyR45A\\\\\\\\\\\\\\\/TETtGkCk34M8RHm9FF7F3YwUF1ahQJXTF2lkS9HE8SvPmeHmhvqFplPtzennNvcASoaWufmADcvZXlSMlBUIb44igTHdvd5P7ep+9\\\\\\\\\\\\\\\/DxXO4\\\\\\\\\\\\\\\/vT6XR9xQe2qpiXoDeoDk8i\\\\\\\\\\\\\\\/DkpnfGyWSY9qDuY2vKhrLy\\\\\\\\\\\\\\\/EPC\\\\\\\\\\\\\\\/a\\\\\\\\\\\\\\\/JRS8cS3PywhaHkIhQFlwpCCj+WRpn9bKEkYVWIvFliVE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SmTxAOvGCHuNXG+qJxt6aA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220f4a18f2b834b405f920274449b55808a15209c175a15df66b309b3b2fd7ba87\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A22.atom\u0022:{\u0022access\u0022:{\u0022reprint\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/Suppl_3\\\/A22.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0037\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-SITC2020.0037\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-SITC2020.0037\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}