{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022DEu5m+sjgIdc4DeIXF\\\\\\\\\\\\\\\/sd8VcoW1\\\\\\\\\\\\\\\/wGsqotXCsexlKhvvW4BExO1bZh3MDgDdcl0H\\\\\\\\\\\\\\\/WMNJ6kCXbFYVNd8APolAG879Rjn9fJMc2M6gEKBeqOdLxP7RT\\\\\\\\\\\\\\\/hsWCQD68Gh5nA95B8pgT3aDUesBQTf9T9hhvHP1RWx7i4crGSCpM+\\\\\\\\\\\\\\\/N8hR22nXfLY8m8Fko90Ci2+14XG7H7cPkaX+bAQXcbxMOZSLQ3M\\\\\\\\\\\\\\\/+DYE0Lrt3TRJ66j8oROK+I5PS1uPF9lU\\\\\\\\\\\\\\\/+mhxRZ62oX3HkpQOTCSt0AChSBAE1VLmV\\\\\\\\\\\\\\\/aHh4Pp70PtvImoy9nNpoSLNkcaWE7oCCBmj38USDgAcfFtQ2eoWS+WeEmBROTKrSk5wtyvNj5E8wGo9XtQeqOxRiR5s5yzmrrjl5E3k16CFpGux9ybX58A5NnHG8MsgtKJgqFZSS+EJMECIGGLNdGTMij9MOQhS\\\\\\\\\\\\\\\/416EdrRMjNxGRTWJxbr\\\\\\\\\\\\\\\/ODT0BRtHNLgmeifaeUn5SpGVA7tdDknDdhmJQYuCk5FNW2yY6iSfRXr84ZXKgZW402kPOVAR0Dso4hDpTH07Q4tO1fMiz59j6hzd6IMz8CjmwOnyBZVjeWgCxi5txGP2F1apWiglnzWHEvL6FDbS\\\\\\\\\\\\\\\/znfbXRmpYzEr233qRjfPtL9u4mw7MaJ+waiYZCPoYot+RptnTzxsiGBtiwgF0XTuvrvtmA2QcYCHRpmBX1XVRLBc9\\\\\\\\\\\\\\\/s1sdMww8Hf5fAvWpF5m08ifcaN7UaUWOadWo+PowSoHg9Hpl5P0qmpPkP+DhG94gUbyKxG1Y3tb3E3Ugky1iZ7HX2mIcay3QEbSzl1spd9B4AEZ9f170BIQh7QFwWgKzJoYveGIu+Dcq8X\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/5h6t9qD0XhwRb2cfA49vBOGvR8e1DYueCq\\\\\\\\\\\\\\\/0gUAA7j0sG4cGB3Azp17OMcIz\\\\\\\\\\\\\\\/6O5GGaDdlfTMrTIv7cBucOGcRcZkJh0TWjI6wC1yy+ieM4cxBt4w8tplYXhKpHALPR5hzKnPZcbXozV85B0cxVoEn13kv\\\\\\\\\\\\\\\/Y\\\\\\\\\\\\\\\/Yzf5x5QeUAY6m1tVAVxo1iXxc8AKa4NHxpvOtKuMnRw2KX9HgcdbhafwBz25GFHx9WR7\\\\\\\\\\\\\\\/dwu\\\\\\\\\\\\\\\/RdPysO5XaWb7qI3kUIMpGHVHZqVeFrkxK5rrJitpjD4\\\\\\\\\\\\\\\/Mryi3JEXSJaWpzFY9GoULKQQqdAlTV2bETwbhTpdONriXlDW\\\\\\\\\\\\\\\/+aAGKveKVL06k1IXEU79iPVGlpTnBJV7k3TvSRZdihtp\\\\\\\\\\\\\\\/J6y3h4tBaXYEF\\\\\\\\\\\\\\\/FVoUX+OzIEacXZb6l2HV5gHozcIq\\\\\\\\\\\\\\\/F07yx4PCeLjax23+oLsSGNj4ZeMeg6QNfnPTJWhqjx3k6fA\\\\\\\\\\\\\\\/H96bgLXzb2uf6RXfsHv0dzQ3MdUULJQF0UNJXyMZ6vnEf7wiwLuZmVhJJnM70sdKglEIEP8Qz27Kw3inf66U4xGXG18lUdNHSSOsspL\\\\\\\\\\\\\\\/GhPqeNSdtgOWvaB5Y2n6CUkp2J67SFpYhp\\\\\\\\\\\\\\\/Fqs4l+OG\\\\\\\\\\\\\\\/FhXgTPWWxafaNr89WG4yEmvmzghn8T46CaRnaksBZv85G4UO50z3uOeonifO4rSJOWp1N+z5MeKdkjD14KaHeOScRghY11QPCUHHoK93MDCF1wo+uj8u1u2w5T0fprLQr6cMvndiX9soraXBZ+xjluCDirzv0E+iXWX1jp6z7jSgts6IChdeHqY79vS\\\\\\\\\\\\\\\/VjnVXuulBOZVdyjBmwTbd8vo6AdvNuWvrki7B4aOgjN2OVJdjFx3HZUjMcu1ct9w88Y8Xb693SO5idjenqportBiHEr9xmSA4SFvHmUe56d52ESWzXBRsokXfF7p+N0eCdgCRpIaIXkxLisTAt6Y0y0QMaz66WeAS1ckQZHMCGehHtH\\\\\\\\\\\\\\\/fNaX2x49gd2+YT0vFepRbXcx2t8DjDhOGTAIbvw4WJ3gu1McBgq9qKArSzPrMuzCplGUj2v4PPNe35x5tr9Qsi8dKp6Co9uZ0HPtKTGeZ2cKSYa6W+W+W2WKg27uIHkds9UjCxfWjRgw4sKuNKWDWw44g\\\\\\\\\\\\\\\/PFI+N9ry0YdzXDIeeqjvNJbkHKW1tFqLW3tuXHu6LJyKnEGYQkQ49UcW7vzVegWi0FAUzvcxnLYAxXJe316HbR3P4iyXPmUcLWbe8baVYp9e84g2tDUYYg88IGtXc8vR8CiuiasZA1Or++am4XkljuC8udSRE7uwc3E2clDVDLHYkwwFibZVl7XuCLVXY4qDbd427GIOxZqLhFKQNvPH9+7eUtwPbpX6O\\\\\\\\\\\\\\\/CgctpsmYBQy6qhb647VTGLKdYg75dgVfmLrrf8pDiRR7dKZx5dKhhdJYe3VVoU\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Pff7ORlOU6VJ7Gbm6ARx6C742GBS6wcTC\\\\\\\\\\\\\\\/hO+VdpCu7d6nQgrciP2Fl4xXKwbutPLUyUy13qTLUXvyoxY\\\\\\\\\\\\\\\/GBX6m3GyHt\\\\\\\\\\\\\\\/qWyBZ8Xx+hIiwTt1KPP2rLsEsO9VGUGB85w2+EkXFBr\\\\\\\\\\\\\\\/7uWNNIWP7mkjmwfO0DtpVJ0FlQiAF6gBnboB4XEuYs9w3RNkYRCnZgn+5hU4R9xLAKTSSvogUIx6qGxz0AUSrH2ifGBT2DPUmaZMFMH1kUK0fyIdpeBjH0jgQRO9bC9eqoDIRkF5DFEElvAOvbrco2p2foTj5TWOXnN3O78EyC\\\\\\\\\\\\\\\/sqp1Aukdxqmbp6sKgnNpsPIwcfDT8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022jeVV3Kopg7drm9gpwdG+NA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227d801e0a65ef742852c36ace5d887b0d191e54a9e7f57976e3db4de913d27367\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e001138.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e001138.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001138\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001138\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001138\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}