{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022wlDAWGeaQa5EBLWcrXf2Vx7XBZS1HkRYCP7QySREr\\\\\\\\\\\\\\\/firtuc6U9mD\\\\\\\\\\\\\\\/cIdr9LgfJz1WsYfp0qSV+30dTeNX5Mv7nKVMJkhqtOWJxTJMIZ4Cah4atA6JMeR9WwuacHzU75RWsIl67zJ1+GxO\\\\\\\\\\\\\\\/mC89dts37V2zxeK8o4AEdUBsVa5MM7LbOFniA3Ha\\\\\\\\\\\\\\\/TL13lop43aibwHSbuoJbmYAe4CX5PIKKAG4SV24FdaDo\\\\\\\\\\\\\\\/xGGn6BtL39bPrIF\\\\\\\\\\\\\\\/73TEm+\\\\\\\\\\\\\\\/J8WS0\\\\\\\\\\\\\\\/R5h3G6fsfMGlLCG5TsMaO1WYJcczwbmUhbRJgykKwZ0W9L1eL5mn8aG3nIfir0T106Mh58Yp8yvFp5cDl8sb4mmrQrNiIAYbW9NVfjFqCLuEtqL4FwmTgE3MZHh4Qi4vmCRGsSpiIApc22nzQf+F4UJs1NVCVEBjwbYnN6zSEsZvqMgsv7aW2w76SGda2ZSNFhgeStpygxoDeCv1uY14NurWxF93f3IMTZgReFi+SL+XRduNa3fdJKsTPd5kMu9hDwt9mwFsmi9TFsAb3PKKgmJa+brvIGvob7aJyo9Vir+4xce62qYY9bBCaWMIwfaMo+axkUEPhbt3NEuIjgMiqnm+ab30Ssf0wKHzDufF5PxGPmKD0CoINfLHlE1yGlX2U3opmX002ZtivQZrACb+VL6T+bkUOonTTl1wr\\\\\\\\\\\\\\\/lmZE+p4zgoPrTT5NAV24JBZO7vbXXTIKe0E37hJ6SB+FHyrYc3\\\\\\\\\\\\\\\/FX062JwkRlwK7bfZVsd27My27s2oSNv\\\\\\\\\\\\\\\/4CvROLTFZfv3gQNBalehJJLHMRDps+7FSqg\\\\\\\\\\\\\\\/ry06v49sjEs7S\\\\\\\\\\\\\\\/fFA1YMo+iqCC7l78uPl5EgwsWgYcHRriQT\\\\\\\\\\\\\\\/USii5X9VitFciuucIkq41uuiXSPwebckqLyQ2b2ezoSM17k0x25JLNpXF6OpUUxex\\\\\\\\\\\\\\\/q5B9p0\\\\\\\\\\\\\\\/mfZizI6RSw5pAcGFWAPwqjIZ6HVT2pxRAEAMNMaJXnHE0C5WsqFKxZbeLDXIE\\\\\\\\\\\\\\\/4KrkNmEi0iUehvbolI+pr22UTS8nldLjyvjNKiHu+F+3OkXW8MvXjZhaxQU4dmiCtL7vYc82azwXMumaEu\\\\\\\\\\\\\\\/cFbwNj1Fl4b8W0zR19wlrhDUu3UHCOH1mqCdoUz0HkJGluAoVolxEkBYpOyBEK1kaEkPcfhiKnPOxoUYWtxGrmkfy6zxgg9j6CZahXlvUwKensu+syeVQCsPuN6UVUrWrpGq8S+EZKhVAN97DaF622fwjYIiTnBXv1WdEOuYBiy6GsuKpAm0phzjyGNsudE8IMP9fzwW7dGcGytFYxw4MBc0er2B37bAesuq7cfO8pOaniTIXEGojDHGWaAoujZbls6GUzjORqOcH7g\\\\\\\\\\\\\\\/WaGFqwVZIGBeBk0ymRLQJNkltFFJne7vkT9hvfkhu6hTfzIC5\\\\\\\\\\\\\\\/NyIt\\\\\\\\\\\\\\\/j5U7n4ZVYGEc1uE9EP+v9nzcmz6uGDnNwqiYqbM+wcR8lMWs5Vv1VRQzCfAaEwX8NTONdM+iXbp79NElnwBm7yt5Ttitrs80vKQ7TY0kyGIsRA7po4Ha3RzaKopJwwIx4Tk7YCg+94wsTbkLgkE2mim6iBiyLBU2uU\\\\\\\\\\\\\\\/9PLDztu99Ni1LBQWKyQFAwOje+nB7\\\\\\\\\\\\\\\/iviAza6fCczMVJ1LZoGWGv8lDtZMx8JC1XH+aw6tXcPuCY4+oiex06p5P1SYw23EqLmbBAxmqTWSbBvDItd3ihNyGH0Pg3kbJdcGXeSC3rMCySIFF\\\\\\\\\\\\\\\/fL9pECh6hiep8lDHIAzLte+Kn6tk\\\\\\\\\\\\\\\/pmhKxEnjcU08AOmrcx8HDKWrAlwQ4zNQ28N8yJcMuwwMCaFbN7DhLYqp8+CY9t3MkktR3mHdh\\\\\\\\\\\\\\\/y69dp35r42I\\\\\\\\\\\\\\\/KFlFCnFTUIIYWdXdn5fdyg5QkOccvIrR4n2FAzdZuP\\\\\\\\\\\\\\\/z5rMbtW7VuCJWM2kDxEqWl6tyORfN2EXr0+9sfdNt4MNyxsQ4sYQ8LveqcY8TxP\\\\\\\\\\\\\\\/vn\\\\\\\\\\\\\\\/MUK7HKPUESaz35+Glfk\\\\\\\\\\\\\\\/FEM2lo9Dr3GD8e7qijkZsuKWMQi3a0bZbUaW5VXmeWpJ+ebIiHdjk07prBSFVc5RF2LtjQnKC6zdG4XXnRVOvXA3HWRIgrZkfad9ea4AbsGx4VtG+455GHHV8mco0ZHU8HSbZGrwUREuzPqTmLlM\\\\\\\\\\\\\\\/87s5zT4SDk6u2i3FY\\\\\\\\\\\\\\\/naLeOTy3uFqfNhXQ3Ie3ypvM\\\\\\\\\\\\\\\/JTw41IbNJL2JBj2hQBFEOnyUsxYh5CqPh\\\\\\\\\\\\\\\/F8AYwwLZ+uFuQYch\\\\\\\\\\\\\\\/3ncYqOji\\\\\\\\\\\\\\\/Tlz3IwLEmkgZ7Evn8N7AEHlScPHLvbCMRwaphWNna4wgUz1V4YbuhiWkSegQbweuQPSby+47wtct46M1oARcgC5SzeuszlA29\\\\\\\\\\\\\\\/VVN9Gyg10Dbd+BFRVkMjqhLvCmiYwsQjATiJ8Hx2+iSTJAWRZzh4fplLpBWHfBdmjsRV0qdZBCAzAkoIJyuJOTBgMjYhY32ni5Euk56PR2wPR05Vrf5Ybw9hCCHsy4S9vj04U4YgHVWm2e0J1zM9EfOromymK7qvpXstcsz\\\\\\\\\\\\\\\/6qWxQBtdGXU1lso2LVzBopjy7Ua5JZDlnsCzBDcNlfGLHnrE\\\\\\\\\\\\\\\/poB0hf2Lg5oedRVLwQ\\\\\\\\\\\\\\\/hAq3OGhf3XccFQ1wWTwIjpOMFuW55jRN6+iN\\\\\\\\\\\\\\\/gd6RgM\\\\\\\\\\\\\\\/lT+7qrquAjebTBxTs1RJJMzkjjpE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022QVaMij1It8dqizmpZe3t9g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022746d1e69716d9198beeb5d6062eaf6125297c9d5335e1256b515786e63034430\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e001278.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e001278.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001278\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001278\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001278\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}