{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00225GdzaIjgx5CoKpNZ181q76gcBiEQOulUEnAWvERH8Sa5afFlMEywPKy5bkPn5Yx6x4lXLyHCVV\\\\\\\\\\\\\\\/2fx6QsQf3MNL3F8ca22\\\\\\\\\\\\\\\/xTOYtjOzyUMmosKJ3pR9sguGlGVfH8IOiK5mP+NZVCo28LBMiMhikSr5521mHpMSJO+T8qHf58DwYN7c95fXqpj+Kli9uLcgjYo2miN+DuOGB6jYFSVBj5Kwv7pJdJJOlUn5Tzhx2YVQ7nubgZ9+7kSv52EPfurL8SpwSt6dq23vKHTQ2WWIV+zL2gwcnhqoPMG+1+fHKk7HoH\\\\\\\\\\\\\\\/Nqg7iXZusG2MH92lJKgXcGItdXj+l18lNmUnCnHkWF9KYqbjmPJuXaXpHiNk8d9PMsLYqQoelwojw1AZIqe7VPYaiioTMv+\\\\\\\\\\\\\\\/r4YWwk\\\\\\\\\\\\\\\/vxaiDITcCtV+WU5pd0xWOlJWZ9h5AJNpfq56YFyxUdutz0oBo+DWt2ipXQeY2Ad0iZncx9r+2nGN04+aL+iRmXNrl1KKXzw8EvPA6y0g6VITq9+wydzzIB0sH8I9FL2MQid+oeH9SDq2QpIZ+0nEU9z6huQyyAMqlxobrHL+7hMfx9lK9+jLVzb6L+4NSZWFk8D514jaJiiEv9Bk+GQGMGyXRarkp+UxuSPdqN\\\\\\\\\\\\\\\/5qOYKlZOlHCUAOAI7O3GP4zPyou9jd77lRMSRCAtvyWIBioJiihzQpfwoJ7hg0d+DQbcb0LoedTMLOxrtFuvbm\\\\\\\\\\\\\\\/LlmMh9g69mfftNNWOoAv8A8G\\\\\\\\\\\\\\\/vRdc1ZHlvpLzKpcM3Iy69eOADwxBIRO5D1GPcF1a7LAreyn8t92bhejkoooED3kKc2CPPAF0Dhdoiuu\\\\\\\\\\\\\\\/rfia1e98lH2i0sAfb4CJKqDbpAFTvqECX3Om4ScFMJrWg7dSl3SHcgIyuKEpmUL3t98Okdli+Vs3qNgfM0XofYce4p\\\\\\\\\\\\\\\/thkPD6uB3KX4k5H2V8Guo1FTCnJMKEFh\\\\\\\\\\\\\\\/LTKGG0dHWr1O5WC2m6Tnky0RjBg08M9HVCZfcJ5h98lVmUQPAvEsyhvfhyrAY4NVZCmD58tJKwc7PTFGwuuNskX\\\\\\\\\\\\\\\/ApxS7+Q1JG2graM7NvPqC1lWrHQa0I7cZMttdt0i4rikp+M4rOl8bYcZ1uPyFzrgbQ2E\\\\\\\\\\\\\\\/0WGFYEye+gCy755idXatpg27Lxr7NALtMQMv+uoM43JB2Ebw5z3E3AoTJA7JwbriZq0CnxPFUBTyD8Yssrm6x17HfCWn5Bvc05EmIIEY94q6stV6FhKw6MujzI0Gsa9GbE9nlHL4GidbPGA8C4H8lDqHQb\\\\\\\\\\\\\\\/WEcMXQPQVydHnyi9egASXH5vaJYXl+Bps5sLW37iiHHt2IIiuBJBZj7WyYXgLvc5Ptg1gYz14ihRLZig0fvyBaR\\\\\\\\\\\\\\\/MhZgqg9LxrREV+R2ZVY\\\\\\\\\\\\\\\/O7BMzCe2ysr5dY2uH\\\\\\\\\\\\\\\/9qHPyo3u7dLE61BZgn0wDM8TrsmlgtOmCRgUrpYZMlWyCj8bwpes07ufRkyO6cmW9uTzXq5qLhNVffVJYDkCrbhD1DymLzUzmGznOFxW7Qlmj5iOZzHdLcge9VQn+Ebj2t3OHt\\\\\\\\\\\\\\\/v5Qh8qOrsjuyCcGUCvR4Zu1BGtFt9FvKc9ruvsj20E\\\\\\\\\\\\\\\/rq73PT0RViVmjB7TP4EY0+5QWCsFMgg1ErEYPVYp3fY9BqNaJCl0i6Z\\\\\\\\\\\\\\\/GX\\\\\\\\\\\\\\\/lhbvCOKAFgl2G66k8QLXS\\\\\\\\\\\\\\\/51S8pW\\\\\\\\\\\\\\\/0E2Aem\\\\\\\\\\\\\\\/uCkTGziwlwEKkzyOJTN10jTOEYNZCE2ibMVrWVCeyYWDgvbihqn+IzNnff22Sr8Woj2lpmm5PG0ZLM2cuFxDLCRzaAEpJvJbJpXJINattqmzQiLUw0Mx3hCj44YVepd2GAJkm\\\\\\\\\\\\\\\/JLet2HSQcRWyBkzTOhkdeMjqSx44Q+lnFBvJH6LirE5Q2gpb3nXYbXLl0dMtJFGi3uFG\\\\\\\\\\\\\\\/VqMp3cy3oU3XYe1BEduPX5K92Atc+jULmwstOviDBDkJJDkP1\\\\\\\\\\\\\\\/TAcfOoGZBO8MA8ye+fkdKtc9yJjoqrtJmB49bZU4VmggpZumrkBCVURh7rZ2ri+q\\\\\\\\\\\\\\\/ZwUNS9RBFpxgU79hcOtYsB\\\\\\\\\\\\\\\/enHNwY+rPK5optLIfXmhP+249C5iuUhx1lyvCcGhpGzHFNIymtY6vQ7cb1lN9iIaRgkrK3ez8EzjTc90AZJyBa0hMrmy7G15B3HFdcFvgXTQHaRTRkmBnFcl5TgWcmdULJVUrLCQ\\\\\\\\\\\\\\\/Opmf6WaX4QKbKImMN1sClLKpAz3GeACmef9fNYwmWeCht194aWWGgVcbb3KoTyf3ygnCy0norCKI+PClmwbxRpXDg4P894RYjwXyUqLK2vG81QMmbFys1r2hp4C6OB5cBQq38D1+3T\\\\\\\\\\\\\\\/YjFhbsbfUIkn25Xiq\\\\\\\\\\\\\\\/32Zq5qJ1bQkETq+PTPslkVjO4cHUV1RBjHyxevJHAHskGlXEdk5WFAB9njcZAo9KrB\\\\\\\\\\\\\\\/fPy5jma5gGJSD0G5SL20iJyMqR4jVAi+AAg354AlBhlq4Gn0YAwVMopJjfni7\\\\\\\\\\\\\\\/a5ZGWTV3mbc22MkmCbFOCEHC36k3NdI6IXEno+Pji7rwiJScuijr3DWtKu9G7dKQFBbc5ZXzaR6fbbFIxlTkfmCpTsPWrYhTZ9RV2e\\\\\\\\\\\\\\\/b5Nu012DcMonS7oFCHEHtcdxnBTXupjyZev5VWNH9u1ZeVCNpWd0SAgd6D\\\\\\\\\\\\\\\/2A5LTcKAOqWNXk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022qIUil8VjMyNDS7hYKgL14g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221aa338286ad48394ff5270e8abe1055bd8cf47dd486354a08229c33e3f90758f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e000207.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e000207.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000207\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000207\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000207\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}