{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022bY\\\\\\\\\\\\\\\/qGqRT2fmiB4ncnz32K5fbMHZ3UX6YPLNBRj+ydaY5STZp2pOgI3MfDit9KvxGmlIGOBcsizowLnM1phJQm1zPkLW5QGDdIipFrflz\\\\\\\\\\\\\\\/vu1RbdigLNIWXvcHJcZ274N1\\\\\\\\\\\\\\\/niCxFxPsJyzgfIjseWyi19ampG55JuoOjyV1YjdFxNoMScaWISvWgYDF4OR8T6VQ0wnQWkHG07ZSaY2UweP+VY\\\\\\\\\\\\\\\/Pbp3LGz2oXGsZng0W9HjpLtyuPgOKnBF7xoR7\\\\\\\\\\\\\\\/av9ptmY3aVCp0dTSNy7SLbO0XerzKWkC76fn6WURgNEttbQequbze5OliN7yyIazNQqwsLym3K9ZMil1Br0ylogF5Hy30W\\\\\\\\\\\\\\\/Rxep2XK79Jqe5rdJksuJB3JWp2mlf3FifuLbZK2h8QwNOaUii0NXH\\\\\\\\\\\\\\\/2JSR2cYlu\\\\\\\\\\\\\\\/x1t6wXW4FvsuE9caAVkLu8a1H3hrubeNmB6JToz0jwGIlV4RPh+RoaWPXnKug8H5meAWhyjk5kCqcDE4k\\\\\\\\\\\\\\\/8Ixg1tjEoBNt1Y+wag3d9GjactU\\\\\\\\\\\\\\\/GcpN4q5PBUtd+kFW0RH\\\\\\\\\\\\\\\/ZVEb9BTlR3lHH07aim+qSgzbkBoZmppX5o76Z1kcmhEYoTNiashqC4c8kQejzpsfTmR0LN1oZUG0a\\\\\\\\\\\\\\\/Joff4zLewcdKrmUnzwvfsvLp6sS1ZWdyvP3EA6DwxMKVWbSocYys8Cmik7ORQ58wfKTxa4TREZgQR5Ikf6TZy\\\\\\\\\\\\\\\/dZBC7KTG45SUuhFEYQdyJfUG2X2RQUFrJEDwTDpA2as4xl5VQMZY6uxcXE9sMqgdbyrEuxN1uhqQ8+t0J3xbQxro43UxeY1pBkV19\\\\\\\\\\\\\\\/Y4G4CEnVWFNNulLTmI56nBXQGCA\\\\\\\\\\\\\\\/M8OTA3pHuL2Bx7Ytpp8lUva2kLgm6yNtt64I6LABY3QOhgnAc+ogUSu6lj7yqIlwLvWJC4SnrfzbFe9nNn7ih5BcQ3YpF2TR8uuodILMbrzVhBELP2DGz2w2mjn+O11I0XsGq3fRnbz5yDknnreiH+ACtp3F48VFXbMXMCw0QK+dsxnqlHWItGiUPRq1fMXhu7mbalecOPBIpTpsiJqM9HeQlC5B9t4lw+u7lnhRP2VgMhTIrEZU3MkHJawwVcQ25fe2I7lpym8vHnCfOfYwj22UhkrjnvWOS4OYn1Qt6wImRLQpFEdh09WMUpFKIxx2XaC\\\\\\\\\\\\\\\/Mwx4yT9AaHVS2nbOiyLvoGKS4eImvbaSgbche0+EaqAJU16h9WYY2qdOxIkfqN9G7kicUzT6Q4gdMW8OXfx5oThG+Q7Jfx9SbUuT7Vfpf1WCoSTbKq1hBxpP+ZYtfoQvdFxrNEM\\\\\\\\\\\\\\\/uAdqpFBM73XiqxrUI5xqz3wRZm7rWskEf4LcLZ66FqOWhS8lvmRfCengGSJ72TRD6mr9H\\\\\\\\\\\\\\\/3oe1TR0usd9Ol+x9Ydfhy76gCtLrpFr9bkaJI\\\\\\\\\\\\\\\/PC8keUh6k351Lz0j5WnFmunogrg0wkDyYan0hSr8ZkPZfxotgn02oX69N27a1DpOBskm1c9d7vngKBuQkKi0IYkktDZCmFLTRO\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/lYrrBeBeXAT5WBitat4C6mjo1dg+hCGQ4sFpuHezF1nhYbAi0Nxv0KoGwd35+WsuKmGK86zsv1KmQAK8bmrovDEz\\\\\\\\\\\\\\\/znxtTJeFWlw1MnTqGP3k09sWqAh7C4Rz90O1qk6mUYrHYb0zelLiE8hOJcfJfPaAn3lYDiyG0Gd5aLvH\\\\\\\\\\\\\\\/inwPoIJiJl8ARvxWuQSXle+qGux\\\\\\\\\\\\\\\/SMipO1EvTZwyqn9czyhHiM+tIabwW9u2qZnxaUhodLhkw97LjfSPa6MJJq1+jWi3JT6fhc47v4Cz2PJVhe3gz7Au0gl8W8vOXe2iR7qyTwkmuzQT792tVwXA4PI9JdTBR5NQpeTdUnaw+BTkcr4QUFRRrGCjkl3id165osQKyY6htqkbsY2XNiOQa56VeoQR\\\\\\\\\\\\\\\/gwzGZDl0+9cDK9\\\\\\\\\\\\\\\/4V1JD6xGksrSItpGcjXjJwyZT35L3rHMARqnUXUJrrf83Ayo8amR7W8gQEA6YVcd9U7+PFI9UaBUIS+yhohD4H5H18bq\\\\\\\\\\\\\\\/rIjliSL7iLUF7VR7SvgO7ngNM4W8RH461TVCinzh5QMO2tklUrlvT76dvPNEdew4J9U0dYzNVj1o8rdyE7OLYSGO6KXKywWdD1trhKUUZHOacZj1SBpMpeNox6rFm+fPo1ZtKTB6LbNYlp8mpGdY5qNKVDiXRG7cDdefdqSk2H56mXUza6QO\\\\\\\\\\\\\\\/mgdOjBW5+2CAaQSx+s9H4+dTa\\\\\\\\\\\\\\\/IIunB6UNeHeuTKPcGJnON4FDGzVEwus7gwMNE2IGZLlhPTSVTC+J2g3o8kKnXQ3mwHb8TcTZ+a4lgK\\\\\\\\\\\\\\\/oDxfuVustVYG6KIx3dDMaf\\\\\\\\\\\\\\\/W1l3HHkGLX1bdlCQ105ZVfyd3RTw3\\\\\\\\\\\\\\\/bWKsvZ4uuKjI7DCIpYR9s1quIdI\\\\\\\\\\\\\\\/myvWbdY7LXyeRIcNQFCYVEoGfFH7CiDJNO+nJmS5egK+56TO46Fx1dkzzPaUhfwNrMoVP7zTTUuqLpS+CZrR99eIKrzxou6z+BQuWRwS5eR42pCuvZUql+Rrei6X4N7CcD3\\\\\\\\\\\\\\\/M6RRHwjilaTVW1C9jfgbGbsvbMhvgE7s1ZRfLMHkfCc2+GgklfHT2Bgz5RXt8i8XsFplWQm84P0GvlMrEqRvdGz6y96iHcVx5Bc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Wm4pIij6FL0e+idb1StiLw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225a7858acb5148d49fa9db8f5b7918013e1724b0c17ff50205f0df853f9399289\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e000515.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e000515.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000515\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000515\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000515\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}