{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022bfEMDAcTbcogtB7hXVM4MBuBTda6gwMRB+p3UZvhOiOPbNt7DyTWpNZUdB7qZYGq3n6vEYX1rCSiltPnxvXTWiEEVJ2BhYGqjmc7OjVJZCP0Y\\\\\\\\\\\\\\\/EiduFmfAh2vZDOkWLotnxmA0E\\\\\\\\\\\\\\\/ThP\\\\\\\\\\\\\\\/V8JJCf5UOU1mZ8vdH\\\\\\\\\\\\\\\/02Ri15IjMKvGPSSXQf6\\\\\\\\\\\\\\\/LlT6O\\\\\\\\\\\\\\\/K2T6\\\\\\\\\\\\\\\/foczv+txyX7cYuanGec\\\\\\\\\\\\\\\/BIdcA23TaGRQtfXUKKQLXdOyhsdkoPbNc4tpesEWHdnNr3SpznUR+AWQQrjkuLjHxwcwJrAAByKb4ThdOord5oyxLGwivTtykLZysvZMqLkhJqHDAusZ7RapQBPJ0ZV\\\\\\\\\\\\\\\/5CYUDO908nSXz7B2UrPORUNzEoCsgPc+Kj4nWCnj6tVhiC3+yerbKYGhwW+RAWPTaVh+L3SM1Oz4CvoYS9wm80QNyrSEaahDzDK803fvVOamYSoOMFj8dljvE8VzqPSK9cqpEimxyvNXVrgHufBlpGhwRJb9dU3iuJK0EtfYwAkuRXKJf258jVsxFViVej43WIa4VPVUuKBrMWmg4OvVmGzYr49SxyS79zS8Neb6s\\\\\\\\\\\\\\\/W8qUSW9\\\\\\\\\\\\\\\/88wZaMOD34Q\\\\\\\\\\\\\\\/cjUbyIVcv\\\\\\\\\\\\\\\/jUG382DrdaiWeCcuGRmML6TED8uYhXsacil\\\\\\\\\\\\\\\/UGtEKr9C7VMEYPJ6YTnyHP6EIvNExhjQIBKpZtUVAfXj7QlnwZwtKhM1VxZ\\\\\\\\\\\\\\\/fH6+zgqeOUrn2Dj\\\\\\\\\\\\\\\/mzhs3zG7MqtQUPC4voevJowVSBL1WC4p9paOVMAB+kDUcFW2QnyTXezwtrYE5EC3RheG3FgJh8sQldkVkrxhOftu1oxbXqM7hyOEfm71VIq53B6udyxlM0RoQnsJ\\\\\\\\\\\\\\\/BwjmlXXUvZXyiBVICp8ibFCzHQk3Ma5nRc3wPenY3jZba6OHijf+nZ5vlTcpGkDhpaD1v+etQb0gIFeaOUxOH\\\\\\\\\\\\\\\/HPp4Rdaj7+El\\\\\\\\\\\\\\\/TCK53In8eNFmd9LTOcpkylmVcGJYRbLYkYksg9gn1ED6+jtgoOlebKGQiyBFdl3ltJaF6nTTgNre3PjTOskMtnGZTp03ZdzFINu6feJSidHocMsTWYnClvSY1gZzec70Ji7nfB9NZpF4B+37YE7OpTUOIb4lBmooTp8xnrFHfl3Hb\\\\\\\\\\\\\\\/hp02u3eW1Z63VX87aveefcrxLW4ZtpbJ8m8qaNQ8wlVHPLO30DDemWbfd68dZN9OmJa+XITpbB3AFKqAwVfG0WlbFp2ghzttqYK86FBZLk+vxaDv6Na\\\\\\\\\\\\\\\/yzka5oCQLBJlZtQ4sf8Uxlldv3rUwm8HMTpsVnpDhoqxDSg2\\\\\\\\\\\\\\\/8M22d5VSeWk9YLMOzlv5uW5uM+R\\\\\\\\\\\\\\\/PzdFW3hS0fEuTk9HuuKq0On48yMFRNTjL9X0gkSR9O6nKOGDgUgdILl\\\\\\\\\\\\\\\/ZfZOFOrDCUu5bV2rTwxW1lhq8IUx3aqEDrta45rZHRKW0iBd2BC1PhW2mC7pgbAnMTLFVM0VfgIKI978BYTC8xd0CQlY5cjoVrwgpY0zOrPmajCwbfI4tyEqAHy2HzmxtTYKU\\\\\\\\\\\\\\\/ai0AbRWchSseVREUva5TWoi5uHv25BkQBUKcXwm+W3iJDsroEJIoEGtOynwZdXO7JrHNpXP5QYMLiCUMpEgJy0Mbv\\\\\\\\\\\\\\\/u0TKBplh0y9bh\\\\\\\\\\\\\\\/pUZO0cq+r\\\\\\\\\\\\\\\/r7Uru3VZD\\\\\\\\\\\\\\\/mbFaNb+eKh4LBiYAqO4g71oHc4RaQ1xgvEQWOleZLzxqRCzDk7mns\\\\\\\\\\\\\\\/HNlxWfFaIYkfWzE6wJyooVGPa0QNNzakntz3k6Ta23d+wB1d9stcEcaHSolF7I5oyPcJPZ8yUymEZhjtkgn492svQC4dNJr\\\\\\\\\\\\\\\/2XD+IoLxx7BSPUEcniIKDCzALuqCS0c654C7yvvlz7VE7OnIl6JsFAxuPbSh8QdQ+tBaVww2aQJTqj6sL1c4RsEMReMUTpov\\\\\\\\\\\\\\\/5XuU9BC3NKbSPeQLt2eKUc4E7QIfndAugb73vr3QvDBA3W4iwq7IbMWZKEiG51ggMoYbaE2rl5MrQP9Z+KoAHISTZnATVmc1G5+5mPMW8C9eQT02M\\\\\\\\\\\\\\\/n60+9rQY8AzC0h1BCN28wk+MSTVdemeyHlxxgjt0PY3KW38z1GHKep8eliQxLTQseaDbZ8\\\\\\\\\\\\\\\/ZnbvueWUUL2T2sT3DSCLBQSNfeNhJ5iTiGMmf6oxLpXrMbvNXSmtm2M8Reo5ypH2QJEDeDfLALe\\\\\\\\\\\\\\\/6hV1YFKwDi6aLMvdzN9osV1qI2lVlffe0WLQC4z0Z0UYI8WsiZOcfyJ+8Vk5+yWHaSQPn1Hhirj9oYBTlANotnJV\\\\\\\\\\\\\\\/CkYewPvBZlM2dJglaW130z\\\\\\\\\\\\\\\/BmJsw9MSk2EVdpFn+Df3MFxw4Sw\\\\\\\\\\\\\\\/MLj0AH2cn7LmG\\\\\\\\\\\\\\\/6Th\\\\\\\\\\\\\\\/OSjz9kAc\\\\\\\\\\\\\\\/1yJzDD\\\\\\\\\\\\\\\/EQDUqR2kydPWdJIDYYB4gQQK5AjbXenjyxZpnCk67e\\\\\\\\\\\\\\\/VwLnl4JLgTUXDU5vQfx5rwFO2KGGdWfSh6+RkH+digboXH0Y6WMWv5EDf\\\\\\\\\\\\\\\/z4JeDSfwUTlCy+EZDbud\\\\\\\\\\\\\\\/5\\\\\\\\\\\\\\\/TmHfhGmh0hkizSkyf0OHsd9rTIBKDPvQqpiOQxz2GLpgbRC7wiWvzHST2wuPYDNPWa1JBC6Z7qIZPrOS4AecQKN9bx7g4zQcWEoPEEEnotL+pdvczueMj0mRjnsvZAqsIANse1Lzuge\\\\\\\\\\\\\\\/NFZWG1rA4sk66+XBvkgCYjJi0Wt3D7VaqmZoejM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022MWkpIk3B8EtXMznJy5OMrQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b4771ecaf045988cc5b5f4003e25e36f4a9849623d8aaa496cb29fd3a3d223cd\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e000422.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e000422.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000422\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000422\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000422\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}