{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022D8Y5VMLhuYkfM8tN3oThGvy9rj+UC5xzF4b6\\\\\\\\\\\\\\\/iRpQ1SxcS8Dola4eixa6CK62vqZov93v+eMRiH7faKpZrQj537E7wV1HnrUMkmpiX9e4\\\\\\\\\\\\\\\/luHDpt+wgScKno7ovy4q7mL14GCIbofXNDkiksdpRzaB9ey5chalJAqCIdL+LksWWh6VKDWQMvAkfPmq7Zg60d\\\\\\\\\\\\\\\/jL0KYhQcDw289l\\\\\\\\\\\\\\\/WbzMXmGG0jxjnhAx0RSAkLeWjLnOYWDu6GtdQ2r7P5k+UXn9N3zYOrr3KgcdSLNu\\\\\\\\\\\\\\\/8K10kib80iksxM6PwUTTO9GED20s7jPOtbyfAmjU2uFIwJJwFHptiduUDOtoe\\\\\\\\\\\\\\\/IJaMNf3QUO3XuBGyu0jJ8PSrRM+Iw34xm0kjMMzx0JHaziwwTxFULnx\\\\\\\\\\\\\\\/+GKyLY7lbb1v0tVk8VT37CQOgT0KPTn9zTL4twIDRdIRuQ2ghcrmTC7HV2FN8d7rdYcNT545b\\\\\\\\\\\\\\\/xFDI0zE2WAXKrM\\\\\\\\\\\\\\\/xSM3W6ggWHdCGiCqCOkVKWyUyjdpRZoTCy8IPrKYUm+bZpqv7aojlScT9jXXDQdFseMlDrE0+GJV44LvjZGnrtw135vh2030MwMISFcMTnVNwD\\\\\\\\\\\\\\\/CFX222a5chknQa5BFmmAeturdJSCAz5hgMs5nkszaHVEQd5VG9OiTR96fBj5EFhfpxHgyTVmrPJ2ybQ4p+pC1wNPRfzZFU6WYFlLdmjqPzDtTHOrUcvpG1UHzw53NdBfuCk2HyvVNt48tI7x\\\\\\\\\\\\\\\/k5ORiA3fAwgRdNzQNqlKhi3c11KyKaLPe9d5JD66HrGPt6J7iCLiTFZ1gephts7YXeItdJ3gDoXjSTrzN5Nr24SErEJc4wcKCp2bJ7D2jKTEGlpGZQTvpEyOPsTm0K14VZnOWlRN7DB4QBnDEL1jKuKFKZKn5l4cWRLg2YNe8VyFB\\\\\\\\\\\\\\\/m7n+dIiZuuzmb0kCCSgVXSEdCwI1pAgShVdPceOrdVdruyQgxvTe48w1RkIg0eQFzq1FROrED5lcB38Rolyp0q7PZ2GN46oJa8nfJtFIIeKqcNBIDe8jYh55jsks3ITENoybrXGz7fbYlni3HDpn+W5iL\\\\\\\\\\\\\\\/KdjPC\\\\\\\\\\\\\\\/l+X1lAhfKfq4B6AXzCKMbPN8GxBNmOLGHp+FlEwM86FM8XnrERfZ18YQnqE+MUEPKsYQMiFqT9rAlHFp\\\\\\\\\\\\\\\/FmKfyI6JjMdZ2k+DQkF0Gj6wCQJx8LAONqBqjlWObE8q7aqNzZ4lKWmCl33C0EbQvtaqBvyKV0dwgkEK4PAazxhWCpbsaqAPo\\\\\\\\\\\\\\\/h4mJWkoFdpmK3obrxqd\\\\\\\\\\\\\\\/7HlVy7X87EE4zmmvrur+b0N1M3rA6XGYbPt2RGdlWqYGBlTdMWQ2p71f1ymtH+k6\\\\\\\\\\\\\\\/v4GMoqvhzJm+lJa9p27Rjc1ht6lawxmjZ\\\\\\\\\\\\\\\/UgRjibjUjQl+PunUXORXYpb1zGGBIdC+8Bq1OXG0pv3U1c+\\\\\\\\\\\\\\\/FL9p\\\\\\\\\\\\\\\/vuNanl4YIkFjMLBNwEeSvLRoVbBClWNqAv4CkHxf+RI62fLFBnAzjF5CMgLSH2F4oziJ8FGxLjyU+UFJwSPwxnUEf8rOtfVv8\\\\\\\\\\\\\\\/bMmAMxZdRsY7ozfSQw+ghhp3f\\\\\\\\\\\\\\\/vgYbtFzBNjqizL2rjrqCl\\\\\\\\\\\\\\\/rxfyIJt39499ex0OejvEWWVvqnFpB9KSCmOr5fItRDc3k9b2UkxNdIhWJs0rAzEG2QRU6anbEXK+5jRd6pBZ+Cx\\\\\\\\\\\\\\\/b45nMoLcfP46Fc9ePk0rmhOGQuVTqyQqw1SegAAocNb86\\\\\\\\\\\\\\\/GbAQmcKh1QfTn+iNPfFh4koGPZ5SXsdBdY\\\\\\\\\\\\\\\/ncud4cJ03Yc\\\\\\\\\\\\\\\/5N2XPfwGAUAhrlluKbMz3V\\\\\\\\\\\\\\\/R8g+OqyhiGiftZmeh4vDYZrrSQ+ERvHqQ2vEaWcaOAIyNGuijbTDqmpMoVzYYzqttP2btC\\\\\\\\\\\\\\\/QlaXYiXxVjZBwZV3\\\\\\\\\\\\\\\/8sQPsRAGADbafJzpys10F3VO3kXPcT2A3+T9TqyysTb9rdjMZsHT0VrzTpPZsClufhHb\\\\\\\\\\\\\\\/LFCJfGK+hsfz3dFrkSWhEXoqvYhnfpVIl\\\\\\\\\\\\\\\/pVpA4GBy\\\\\\\\\\\\\\\/Ycgzg2EfJiOgZwASJ6Vliijd42T3rIO6nr2jzTChFLdCQJU6UWO0tn1FCVPxrRt2yNNUQl06oqNSoVgJ86LpAgjQ08xbHAHjD95no7URIOW9Zc1JY7sf4A6\\\\\\\\\\\\\\\/Opn8OgkcTUlktywOefH7oW1mIfC7KUygnAfw7yLemdy0UrqoO759Y+YPC2q4C\\\\\\\\\\\\\\\/hrD67WIdC1wlAKRYGPMf6YtHVIKLalqIhcuyMa2Max3bMzWK4Xh4A\\\\\\\\\\\\\\\/Lr\\\\\\\\\\\\\\\/7xK\\\\\\\\\\\\\\\/8w2835RQxiVJR1RGTD1k6f51zd\\\\\\\\\\\\\\\/WIIeH5aLY1aJ8eGCqZyMIbK4nenFxvPG6pHe7HKqye3Qy5Ix1g90+Vwu\\\\\\\\\\\\\\\/PX1Ipb\\\\\\\\\\\\\\\/oXgCeg\\\\\\\\\\\\\\\/ELXlrVyLxhgNM\\\\\\\\\\\\\\\/kwl1zNICf2ktb+mAGpwKJdqs8JIfhhX+LD74scw\\\\\\\\\\\\\\\/gcbLy713KNB4AjYYvdVKw5zvBGXRwbQHMRMOlrTUs\\\\\\\\\\\\\\\/aKXmL1Dh\\\\\\\\\\\\\\\/7og6ak+xbJNVK1H4oG42wVg23FKKAVk36ZJ2niAiHxZ4vkvVLtpCJs\\\\\\\\\\\\\\\/PTDYaU+Xoy5H4W7rLtiwAstnW2Z0atLO+uzTTnnIPY4HhvN8WfdEu4xBEXyvukJdZOyBDGJl69n9XK7ibm23uT9r6v5RqABsat3WmGKRx1IbKV6g\\\\\\\\\\\\\\\/7N4o5FT7CMjxt1Ftug=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022i+XhOqQalg1WwKlwadQ3kw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227639fb2e22d0798f873cf60aeaefd84e149af6900355e9ac5595ad346fe414b3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/2\\\/e000238.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/2\\\/e000238.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000238\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000238\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000238\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}