{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022wlTXp2sCbMKO38sxy1Psy6luqkucns+U1xYluwa8npq\\\\\\\\\\\\\\\/9YvgIvWOTUADLtBBQlQH2ozQF4VuGRGwXQ9rxQec6bBJd8O6muY29o\\\\\\\\\\\\\\\/tip+DqYcPjbt0pghEV+M0wWBky5tZGfjL+0KWVk\\\\\\\\\\\\\\\/3N9e5BNn6KkrjGzDtAQcCA+ofCpSDZecKq3Ebr4DvU8xCMFL3mihFTKdIyjThNcLTkDvOzFqCwgv15\\\\\\\\\\\\\\\/vxBmiJW3ts\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/FjCUVRJF4v6yQQzExZlhaoEMqYiW9qwCp5DecbOwkhd9v1mBnDxjTGEr2hZBu11CIfuAp\\\\\\\\\\\\\\\/qoBfZPuipu7YBrodEezJ7keIhCcN7ue7W2lLb\\\\\\\\\\\\\\\/JXVDJFSqgjXjXXLw2QuG7sq3tg+CTJPvM+u6rUG\\\\\\\\\\\\\\\/y8KpFTOJrGOrUdq\\\\\\\\\\\\\\\/zi\\\\\\\\\\\\\\\/Zg61u23qajDGYX5LHtiUZ2xOiC7BSgpTYCCkIa1q4U9fwHrCAzHueAZnI142a12OzP0HZAOglgMP\\\\\\\\\\\\\\\/q6W8c3Dvnn1Ly6TtNZZGhrr1RIVfbXqx4wFPA2jqk9J3abhi3zTHYlLtQcKdXvVS81bwwHRpb7KuRpTH9mce\\\\\\\\\\\\\\\/bMQDFCQC+2PXH42K7KDYtM43BHI\\\\\\\\\\\\\\\/Ude7p9dNpBMwIMO6ZdSrlyMLwlif8rRGNDRMcrTDtIYec8aiNMwQ9OzuZBPd624y0ZpAygYyC+Y9PmomcIXiiMD49qNKuutMPH6fO6LQl782gabl+LnL2oMa1Z8o9n1Jd7PsTcbkudUghmH8vXfA87tyRwUUZuzVDz7Md7kXAMBIZABJawSfvZimG8EKnf4ImdoOCpgY5SkefStyS\\\\\\\\\\\\\\\/zCJOqoC7JrLH4PY2qLrCiG6KEtWGwToiFQyS65JceUoKGDYmVzA0CQqPgCGk9ooeaW0A+O6z6+R0MxYGVB13MualfYo31kNOflLm6HaHUSWaF6+KJAndau0kxM+NqRA\\\\\\\\\\\\\\\/L+YUU2FIex1q6JozyfPPp4byf24Z0i3FqMJCi2Hkkv+IHmWHBZnwytQDmX+UkFFxzq5CyQJ5PI97y9yN4la2\\\\\\\\\\\\\\\/nEnwlAksejxZM2mJgYJQixbnvAhFnFOWhYfN2ibwUhbPkDccEkZDJ\\\\\\\\\\\\\\\/4VaawENXQ5edKock3rMVFU8SAdnAnWKyII\\\\\\\\\\\\\\\/1m9mSHONlGCFVjXJwwrqP\\\\\\\\\\\\\\\/w4pNypIoh5z9+eB+YCzHv3G8qYqPkbGz1xZn5F8IRJWCX8OhWDxhO88B7jRgwKxiL3y45BOubHdlFLweva0ZPMzvxShiQEYmYsm0T+rZxKcwvWIkmVr5sjMnjgEqvX49aHCGmtNruAib172khcZTkJxn4GFcjtJookMwtTF0JZbxt2nKAkrlT2D4I40q5N6KyBYkorGEeKyxKqrW5p0EdfiqjHwywOS+ooNNOdDGg49f37FwBe\\\\\\\\\\\\\\\/mfgBduwCZW\\\\\\\\\\\\\\\/4y2Jl+lkXdxqnjLViY9dMYm8y3udCIeeWNoO3YW928m\\\\\\\\\\\\\\\/Sp4xgEePhTUytO3D266PxAjpBqXJs7oWk+cqHUpim4TlT7thTueOP+fIrYUWnmOQCs0aaOI3+RMeATrgKzKrJJOkQIxr05yY+NwGW43ZqkMEU\\\\\\\\\\\\\\\/ghm+KW1qksWd+o3wP3vqrS2JojSYNThb+OdUN308mzHTU93OrZZXYgWsLqjY2B2ZlPohOVUns3g3XwBpK6IFQTJ2nfsCk\\\\\\\\\\\\\\\/kpnSwNleO1KMh5Zp4DZx4lfljI8dHq3ATiEcHcirP8itGIPkv4714GsMzv7v4bpD1rBddxcFnRU\\\\\\\\\\\\\\\/te2QudVoSkdrzgZQx0E1kULlsz7ywyig70w4JLTaj5bKbWWes2L7AcZFT\\\\\\\\\\\\\\\/nqIOMT+r+NZeYTL1RWCRctBknwYV3xsntHAOqpdHTRKQTBG3iJGQBFR6W0a9lWhgW+1HJcq1v1VUqUKINUEjVU1dSAIQACKwnV\\\\\\\\\\\\\\\/ZMLEo2EQHz4s6ZJ5gVG0u2hKKD+QbMZSlxsnMtdbnGEbcXxxax8ykRIpGzSGjCkwRbuG\\\\\\\\\\\\\\\/+z97O5mWtHN2f3RhNq4AsKJMAUVMa865LxNbmeh45LwJ0C767j2DFNglSDO\\\\\\\\\\\\\\\/B0cafuItk7nryWqg7O9YY2BEkVBRkM4UJepI1kQlzCMBnk34sinUvYkyZnixO9Lb4Lu3ym6VOvJdpXy9a8BYzGMiMyB08MY9+ZAw8XZMgXYHpXDHeSfoSsVCOXPx\\\\\\\\\\\\\\\/sUwW12auYgPyWblpN2Wo+oDFBh1ZPOrMiN8G1CPH2ZJL4KgOGOd7gHrcS+hWig3Zb3ytMVA3+Jj9KWjiZVocaPb7ny+HZKjy+Dj5bfL4C\\\\\\\\\\\\\\\/onGj2pTfSbCF5repDS4xKv38BfpMVUWWoSeRPrT74ica58Qxf3COdsvQY+7d9\\\\\\\\\\\\\\\/cWErxiINyGlr6c8wEOCI5SR11aWgB1ZOfdVoHLCAyBnpwcFj8DKBNI0DKt1hRHxHNIlHd0APTRoEmw2g6Fh\\\\\\\\\\\\\\\/yAtqqviEX7nM\\\\\\\\\\\\\\\/cbhiXBj6ddK7tUz3mn6bBzIrJihuOevuW4MnOIqP6uF\\\\\\\\\\\\\\\/hH2edUkZMZVWjvmxvaHg72j76D69jclV90VpY1RmhPnuEfY\\\\\\\\\\\\\\\/c9YwLnqabRHnea5wjMvq3MuooGP0e1OOjCyhU2GA9SyzeaEX44SthgWykEkV07VBQxaiSp8fxqxf19Pv8umFw8U7d2IO89\\\\\\\\\\\\\\\/+R9y0iYezyJlN9DTB\\\\\\\\\\\\\\\/0je583re1kmPO42rhtCO+T4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/qP0KRycUYPSXfwcizJu9w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022285769b567489890a8d7bc6b0f5864cf78ef784dd2f0b1044e8defd829d60458\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000845corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000845corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;8\\\/1\\\/e000845corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000845corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000845corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000845corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}