{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022PrWX4APs9Zbx8iiKg4UUo\\\\\\\\\\\\\\\/HD51JjCyplYlHDHruU+nAa6QeLsnrkvjAankFxvpqPnNGklRYbVmeaS5kqCaOEF9ffnkihzLZQtXabFDK0o+NOlqS2AEqRzmvsQPFP5kYwe4QpxrA9GeD30824FxMNNVsOEFyXUBKW4Fd8zIdrDUzPqFtpkf4IoD1pTB8LF1Ylhngg80b65vpTMD8U5v1sOhQhXRa6pWCNm0i9nCu4B+FQTew3w7t4LbKpAln4EcMNaSxc3Q3oHZonyj7dAEV+YeziBxdfK\\\\\\\\\\\\\\\/8eKOI2HLO+keInOZpBFf7Er5PJqpU7vYUi8FKbK1PTm1AJsknVd6jUZzXnmJOwRT7WfEsdf1XGkJHSLXR1WR7bWaPrue+LFXbWR42dcWOesRJrTI\\\\\\\\\\\\\\\/nRtVfnOhkQdXerwCaArUzkqHXnnZUbE8H91DkOUb4wbXsSFdH56V6HhToHYuoYgIWEkgwV7XwpDOMfIRu9H8Z28qVleY9avrnZfWYCYWjU5Iml4j4Zfe\\\\\\\\\\\\\\\/OYpejabOmAtwrlHc4UrFyibGCr3ZkIhpgJVrBGVEGAQxnem+jOJENXsLXjKvoLTnGaOmgUW1i7rbG\\\\\\\\\\\\\\\/iFMQhvVFKaIi1sXs8JzTikXpDMdu7DBuzwC0BIUGWwaS+fWaOyBh2ZFn72LNRbdPLUr4UXnW5vbg2p\\\\\\\\\\\\\\\/8vSjMCLfO0iXj+0Sg\\\\\\\\\\\\\\\/TDWD7Juj\\\\\\\\\\\\\\\/hOXm\\\\\\\\\\\\\\\/0pAgc3fuTt1ZkJ2q34zIL2qjUtMLskolYadn5NS5jWWXD\\\\\\\\\\\\\\\/MhKRG34GfksbKzGfPP6hwvfIBK3uMPtbOnL+auarx\\\\\\\\\\\\\\\/REHwLGzeSJen5QQg+uWKXm2G\\\\\\\\\\\\\\\/0mC5gdXrYM0MY2ep1tGYLmogtKV5BXrZUz6SegJ023vWIx5mGxXRFR0b\\\\\\\\\\\\\\\/e0S+j58tGI+XuvDYZLYGDGnzJQrD21WjAIJtwtfDbCX2CX3HQSh9ipPXw8MEX2k9dxYJgVZkgK5pf0kUG0DaOKfug9uKTSCciMKcUel3gWh9V\\\\\\\\\\\\\\\/FvVGb9jH6lh2LeS+dIQKcGVGC8ukATQdu5oL3EKkDlMfj2yWENUrE+eHp47LffEvLYbOP6leD+N7PeEl+fzK6ksAsA8VI4\\\\\\\\\\\\\\\/CwDQYZ43l50cKFr11\\\\\\\\\\\\\\\/4fYWJML19ApcddEh\\\\\\\\\\\\\\\/svd24JoV7eRrZk1U1oT1JP6eiQ9s+Z0hNA2Z7RQBM19Pnr6sBOy8HFjKHgwdFm3ve3MU8Cwcb\\\\\\\\\\\\\\\/QPCLun83WahMFTd0plzPiweDlcQvF1DbgmXgrW6D4mJn3jMB8Eys8RxOioAUllJ8UCt4b\\\\\\\\\\\\\\\/TT\\\\\\\\\\\\\\\/f399QnKE2iagFAt6GWlvA9HM5bZG91iBvdwoLn7C5+hz4xF2UbTyyM0cf\\\\\\\\\\\\\\\/6xLqEn4NtTWxoSUgYJTeVpgYD3v5le7qWW5LqMoHMvdQKxL2c5cRTIbBlHvsI4\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/hZHiVXYei9gHje5SF0rydN0ohpAjYlYcjG\\\\\\\\\\\\\\\/MYPzdSMMPdGcKfQiAYsNhsmDkOlOpVvADfd73RkTFOc6fNPFY+NFWlrLnwzE\\\\\\\\\\\\\\\/Xcytz5ln7u6njG7VskgP+ILXXYOQ5GIq3g871P5G61oQ8e8kCG60UD5TNqbDZfxfXuYtPcH1xtUEux1zH6ltgqv706kbGP7n8bjCD9OEl3+VLfs8zzRZ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/JZ5fliqYU+BJ6O1UF9JnsO7N5wWqkcIyUos7lKarMkjfjH7ul2wPLPWkNVZkNWAZ4Gz5EF\\\\\\\\\\\\\\\/XvvS4ICFn20tpSOXk6\\\\\\\\\\\\\\\/ZkfJQWrhzddymV9aYa8mVWzaLwjejHeQH8nOazJ3Hb1P\\\\\\\\\\\\\\\/qxc+JB\\\\\\\\\\\\\\\/Vn8cw5JBLSYaT7WQ4MSZtmbkOOtp2b20zNG7B70IcXfmB1pH6vn7bVNzepPZUwTeDh7wCptKJn5OSxTz\\\\\\\\\\\\\\\/bt1CC97ZJrkoAglyEVQSkFKFI1\\\\\\\\\\\\\\\/eHnNnhyJTRFDzlZhmDWLPQ9ap5R9bo8Tv1cA6r9hQiDfJMXoHJoQwzDuEn0MgUgOv4t0XGZvdUp8Bng4HhUaIV1GE1qzhs\\\\\\\\\\\\\\\/HCm\\\\\\\\\\\\\\\/E3soJ8qguh1+JeesR55mKbVP1Y7MvTLVAtKuWMDYIjA4YXfnBIXxGN37e8IWmHenY\\\\\\\\\\\\\\\/HFEvrJJKEPcau2+ZGWMAP51WiUL+TFnUCusJ458AwObIr+SpW2bjeoTbW6i7Bhy9Xl7M8qHJwxx2Oo9Wo2w+OksHF40FQvdaUqcuA4aW7mlxYQtAYlD6HT5F1nmaRw4xncBBSt9vkY3kHBkBd6zbfWGszSTO3XafaO0fWDunN7TK8DBRqOSs934n0Fn2nMhcIN453H3MwEXPIWZozZ60COTV\\\\\\\\\\\\\\\/B03p4LF4flLSxhJ7K5\\\\\\\\\\\\\\\/dBDT5+spxKV9J+KAaz8IeXWyMySEspqVLZyrbmfBn1aE37TY2F9g+NmmFmb5Fma4yKF6vmqCZzHNbk9zbJtscPTuhbfJOxHm2kYTz+IfgZqDlbwUdVtubbLcc4CqBptHg8Oy5bA7SRQhvHOmIHdRRMVWIArIMwden4K25prT3kt9hOY1G18b54Pf\\\\\\\\\\\\\\\/okeR5qbvOMnnSmh4Ehpoi0Zs3Y2NPdH7m9jW\\\\\\\\\\\\\\\/X\\\\\\\\\\\\\\\/mLl6D1oflnMR2nfK+kugIKIMm7bSw5EBB5C7HqXxLNZjTYVFgkHvq330mt8Ms+xOjGOcZ4phg0I8rffL8QqXeyW7IZwsfLqKrNMqgtBiR1KLZxb9r9WhDszj1jST94YEVY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022eZTPd18osHCl+bPTI8YdsQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002242e5defd72e54628a608d9fb58a9109362ade83cba9fe9ebf99afc378fefd387\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000230.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000230.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000230\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000230\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000230\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}