{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022HJORCgSrjrCJIc4E9POnqSemPZrsFe7RD8ud8AfjhZvdgz94OXCg3Jj+MCbllrFNng38DrIZr+tdhBk1r\\\\\\\\\\\\\\\/P7bsi19XuNRq63msBYTwS+vecfOwD8\\\\\\\\\\\\\\\/n5213+JiLyxhHqybJ8ipfal3ummlhwYBDa7YRgOkxTN+qN4HYX7TY5AjC27r3PBKH1G53Ye1FSF8FnPNOkSb8KLeVl0duaFsWhhfouv4+PI5lrsVWJ4hG0kTVwu9BEnOZ4E3NtuTmvXIFE83tjW3FeZpdZPqMduGTy57ISocLEfo1hvnSX6+jrhW74jPNFgOxSbNv+jyQImGLCBWzcH7BsYBx4DDkEAwq6JTYcR3IESOQtE24n2hiYzwwFab3WvLDMiggn8PDw1R0L83bHLtb2Uevpjom0h87TUxykbmQBw8DKTZDtE8aa4riKPINUAXFGBFowW9wGF+KP2nSkHP0IWydco+1JONJUVcLty2UsG5UXmDnv4TrebC5o74wT21wA9FUYSuBEeNRJ0kO9Qdzl\\\\\\\\\\\\\\\/3X0ZeaQ\\\\\\\\\\\\\\\/NA1fIchh8KAjaEGxkkf\\\\\\\\\\\\\\\/xcOMd1zSLlAyah1F\\\\\\\\\\\\\\\/WMPIKJLOQL4N51Ecn3ruKZivr7SyNGdQ6aZYJeNQRTiBVYtMd46Vh9G6hLaDH9l9wxBSALdz3XxyfHgrUvNCBSW8jO3oskoVqciWHJFmeAukzkh75iCCH7N3cqzD4J3KuuWWBNfJfrWRJnOFSM1nAq0vvkt2gLLf0irtSpqDehKQQqDvChboR2v+kPAFlVi\\\\\\\\\\\\\\\/muUhPtgj3YnLAPgYijEjG8UXlDvnQ4yEDdVuP6iHUYcUr6tFf7P14L6qPhN9zioc7l3+j+jzXuIkCmNMGy5JRBqbBMF80HTJCN05waftPMYzk\\\\\\\\\\\\\\\/GKILqjve0s+TsrD+gEpbKEq1OoqG2jywHwifxAw26OdosX1jxxF37ha7zJG8xCQkC4HBg32qfth8aH41rPlnb3chOA5l29RWiCDU8SuaHgxIzoladkCJFpIKB+GlR19LylhbuASdnDbkIGYCATc5VWB7a6COFt5soBogP1oUO7sxR2QxRndTyQ7V7Tf\\\\\\\\\\\\\\\/zjnFFg+P5F9aIYls+hjI1J51kEXe2wHawGQbkUkWuiRruohvgQ2TTWsIdmK8D1UMGbzqUVYcjOyMq+sE2\\\\\\\\\\\\\\\/3Pk\\\\\\\\\\\\\\\/WIsTqSr+LogzvydkRxcDy464cW1rD1bjzCOGMZjFH3cS5cIAFvqKZ0zXCD8mtqYye+3HPrbTcUN354zslc8j8eXrw4jau\\\\\\\\\\\\\\\/zrtGrRUsX1h1TAKttc0an2saHLBwbp9pDvKlXgaHXGvyLXLqhVBCh0mcVy6pF7ULbVdOAq9wmZn3Kt6G4wHrjoYsX1tVkD5F88wWma8Zinkd0b9r7YlWXIqfqREqnf9UDZhjoNjmXRIQebfv4c9NKgyjWGLWS04NPhcyMvnjDXRNFdEw71btl9rAnFuOMBkguv\\\\\\\\\\\\\\\/4dlr\\\\\\\\\\\\\\\/NHba\\\\\\\\\\\\\\\/dauj3JGFvBUyDJ1gLOr9goy75sa05ecHILHIdLeWaYNTk\\\\\\\\\\\\\\\/qQ7mpF02aj5oGwo0IdyfW9EFCJPJn09qQH9LLXT6kMkKzY3UbpsNlpBeSDf5wk32AQ6PaH9i\\\\\\\\\\\\\\\/UHEcXnYDfg3bgxnT8i3ABMW5Z7DbzO0SO4iYBgEiKbL9HojRddV6NgSDwKyUzHBqVrlTNuVO+lrN8xR7oWSNVIycZ3\\\\\\\\\\\\\\\/Ci9iN5PmmIBgflFkfnE5aSgkuhjUQUSOA7ukZTc0T9g1vZAfx8mhHeqJwFPDj3jZfQeGMsR4GPoa9Fec1LrSYevM7eQr+X35TtCH5aPh3BhpXBjlh8dafskw2cEW6yxSNE4BWLJmeiOTlXbbrtK4CrcTNaEBpQUIghnJLi6FWvmA5O7DOg0G8Zsv4F8uGt0ngKuSJcs7xnzTBJ9QeGUKIF6kxYeX9BiNbpk74VL989YfNGZ3IiNxV8g21Re4cFQpbEIRl0Z8Ldtv4hvcaUO5gscI7Dunbhv1Yk+z+dPnONltB38b2F+U46EiQOvt4HYCzk6JRa6l4SMwAAxDzzR5VWkJv9NSB34zGnYN9H3N2iW4ZO5xyWuXxrDRjyq18Vv8vPBnlMnRhmSSEFRDiCHWM9n2gVcswhCZK\\\\\\\\\\\\\\\/mjOU1nJF2tLF5o\\\\\\\\\\\\\\\/I9c+tE5A02vlGP4XbNbeIrwpqGNWO3GFXqmWI0zsNA0NkgBBiKLztJaToaOCz42Fby\\\\\\\\\\\\\\\/FDIn1m6Cime5eNqwN3xSeCAk8N5IsbNce1sgtVU+kzjW8Olri7fVOO6T\\\\\\\\\\\\\\\/ttsmuQ4uTOktNSoTULeDkYScIGYb6vG6JQEsioUch2I1s0bxoRQZQv+RSk4QQSE7hhFVWLetrbkWUe75lZBwRZPmowhhztikcSwXjicFzXBt5YgkrTUI6ApceyFD\\\\\\\\\\\\\\\/URyUWlWTRV+EKdiJbTHths3VS\\\\\\\\\\\\\\\/hrREArpqF07IeymWrL3Pea9eoS3ScoucFJ9g7aFMgvm5AuBTbozZCgJAjeO6WnkMdpx3xgR4g\\\\\\\\\\\\\\\/UZi+fMfe7QSnrlTX\\\\\\\\\\\\\\\/zmL8UM8wzcsNNGy920IJhDxTiwCHuKkH8ldXSte1I2jffiYB76PKY5kPb10Z86v\\\\\\\\\\\\\\\/ONZmMlazJkqu3n2ZRZuDeNFrvlZBk10YI2h19frs8ygmEuv20DEw4SHNMKB5gmScRUTv5CCBk2jrPHToV3CccQRJlE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022B6sFx0q33+oJ3Hy8ooxMbw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223c0382fb06b3bb10c32001fe3447c485a297218309a4d95b26b2ddb65a7ac3b3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000543.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000543.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-000543\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-000543\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-000543\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}