{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ILzOtLC0lMJG8ST0qQzAxu4MSsc26vFBupy2ujUZLBQVAPljHOUmsQxKFV51mEAfDe5e4FYOXJIsEbLlOCwecjrPWTY+Z66h\\\\\\\\\\\\\\\/aHbcZwjD6Pf54pYfBTFYzjw0UD89SuEArqqUuCUfMCQZi+BRMn9feuu\\\\\\\\\\\\\\\/5CunrnnpzkfemJ8onN82s3HYrCXfOxqR7TKOuJAKVHZxuOYgYeGom7\\\\\\\\\\\\\\\/B6cnkwNdFNo62YaaXq1JCpxvW+ONw9zSKTHXMIGgP2krdoreh1VOReMKlplVLLg1tcXzCp0dnyMSdrRY88EogeRm8wTdEnlvZL\\\\\\\\\\\\\\\/B96c\\\\\\\\\\\\\\\/29cvCK7P2GysB3LGMcYoTQFWpPHyHytPvgcnvicTo6ITAgJYrrK84cAb1O6+CKsgAhGAOHv8DBHwI9fCJmdJ78x6WBtGZ48VpNCxZdj2D2cvfocPnII\\\\\\\\\\\\\\\/XK7SzCbGGaq2zFDEIGPA20QpScRylXaafSiBHPljUCHzA+70+3hNsb2P3Dp2EDI6oAp0U\\\\\\\\\\\\\\\/4VLpjiK4n1jPmS9WaqTgIXA0SQ7gsXIB\\\\\\\\\\\\\\\/SOCHVzwTBx5SzjA6MpUYPrW6fyRSuql+dJEZMmTGNdlqxJmJngt8spONhwQAzoZOxAG7Mx6niLNVPHFxzDbNXnqvIb4zhgEENdyzk7xyd8PMjlDLr+kbH3NLJmtPmn5eb\\\\\\\\\\\\\\\/FQWHSTwA3OhGmR5+f4p2L83CqKB+xv+MdArp7fBSqv+b+pBbNVIBTdM0aT1aduJMyHsgUWZ47Tf07tYh0c7G+EQb4i9p0WRl9Oxp7Id1vHSuI8Wxr\\\\\\\\\\\\\\\/+zSQsgwaxy277BaKVtiJIw0O3hEwBHBDct16oXBZGo8ESr4SB8Q6zseOoP0UbmaNqgWb6rpvSIo6KujP5RleI6iBlfw7i3swMsn0tWP4\\\\\\\\\\\\\\\/HFnbm5x2GCNNyKbdHlmNn2bVJU8ZcsfSYEPz8pD6VlJM3j7Hu0ArSf9LxnB0w6+G4SvjDiUfAZ3ITdBDhFrVxKj5TE8y3wiW4DcgyH0MAkYip8GqpdJIEIa197U\\\\\\\\\\\\\\\/+UFlwwACdp5iJcJEto+b+5mGkSnuCdNabV1Gg4d4TkhweG4t53OEMC\\\\\\\\\\\\\\\/ntLDqzqTlXSCaHG\\\\\\\\\\\\\\\/H4EIEnqUki8x33fJ7glY5XAb2VF4SbxKFZyo+xrhKdDeSn\\\\\\\\\\\\\\\/fJLMchsYFGxWTcLfCTKL8w9+6S3VTHPpHPwnjQ2QxV8LOvR4VCgMcWWV9ZcbFd2kGAo6dvtkboWURa7uWh6J8BmJDhpQ57sP5U8KPMktubeppFB\\\\\\\\\\\\\\\/ZAZqQYFrfich5m1VP38zYhZ13Dqfz7nCwj19Uc55rlQLEa39C6lBVJB\\\\\\\\\\\\\\\/9oO+0Hn\\\\\\\\\\\\\\\/pG63eWmfBeLluB+pT2KnnYwtPb\\\\\\\\\\\\\\\/9VEWSnOrKY4w9axTbl0GGUGCQHyF1l3PRzEk1c1v3f3crWHiO+ND\\\\\\\\\\\\\\\/jocSRYecnWBiyzX6t2OfwE76aZvftXFy26AROTpUXjcV1OitRDf7EsDTB\\\\\\\\\\\\\\\/Gi0EtSbFbbfJwXk1nzc\\\\\\\\\\\\\\\/8BWE2BufsPC4hmLLbCH9Ww4pX3CRG+1\\\\\\\\\\\\\\\/VgZkM04w2aYUG7PSTnylWamwXIvKr8TC+WdwhdoWTH0Kfi2hZoZ\\\\\\\\\\\\\\\/+tGJykLeAE4ySckZjm6lcpiZqDI7OS4N9tvAZ5t6vLlJ7\\\\\\\\\\\\\\\/cDmY2OMUagvomyYBX73Fh2aceedCGktBAKPm\\\\\\\\\\\\\\\/9EjHw3eJt3\\\\\\\\\\\\\\\/F4w8krIyoaD5UMNWH\\\\\\\\\\\\\\\/zXwviTpv6FdSx8b+Sjr87gywAVQA2Pmt\\\\\\\\\\\\\\\/EL8mAWPL8WciyPMdavuFepf8uUy1Cxof61uVXRXFl1UUu4PNqC3M+gRbAeZUa75waCCcUaECTgiDetPzEVMfx0U\\\\\\\\\\\\\\\/R3u4X18l3KriD5Nkv6cIqK3bjx3Ih+hQdzpYciqAwz91+A1T3rXFpOndhZAzVslmIeIX+SP219\\\\\\\\\\\\\\\/a\\\\\\\\\\\\\\\/vJtNz7DbWsxik+5fR\\\\\\\\\\\\\\\/Bh8Fq17Z\\\\\\\\\\\\\\\/zoU+zu9ZIzfQ7ZruY3D2G4D3ah581EJjL4ZMkdOeKNs3NqxiADsfphq1+dIbyKHcjBWLIXYJfbalrCkVdx9hjc\\\\\\\\\\\\\\\/mDGYSRsoeE6J0DaQxsZwZhMGvZ4UxMmlpseLmnlva9ZehctUmrcpZYVKpePCtpilaBm3AmTUwaU3PmyrZ8j\\\\\\\\\\\\\\\/v3N4Xkqq1C4jQxvD+urokfGEr3dQ7f1yUN2PG0M+8Tp\\\\\\\\\\\\\\\/axv0GL5fPml2f0P3Q4L0FdpBNuw1nWxpbxsedsg5b5sbok9fca58Mp63A6GMjQT34XVU707zk7KH2esRAVkmwZUicslfEBgpM5vK6\\\\\\\\\\\\\\\/aoS9D88I\\\\\\\\\\\\\\\/BYHDMlnIAhsO4wgMOhI6nvCPhqulSArLPN0+yzQSw6JK6qvzmqgd8ALpFexJgn+HvMlHAA00yBobjKN43iWGGWjRmkSz0gnPcitFk7nznP5PKaqoD45IvWP7bVkhVMCy5807pmruY7Yc5NHsDMcgsoTpPezscVipqTvGm1MN+sJOmFZ\\\\\\\\\\\\\\\/2hPjUa9Hb+fMmIEIyyuIUtbrGnZ3EzZGyShY87rlomwuu5va9uZ6PFmtJwAiiG7Gw4phvjAbpwv3Va89CnmJUDJ+HD7VCh5PtbgINNVD6k4LURiLlZMdzbARCtCs8N687E4ucNHuD5xIjOmaOW5zMy6zOKgtxGRSS2673VDijcFz86hkpvMFha0Em3jk+Tj9h82wNbxSShj\\\\\\\\\\\\\\\/76v2EKV+onRakCtsUxzs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SAyKZWdSGgs7xVByg2nhCQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022190779ec5440814c2d792bbacc412d0682c7f0653de220d46e733c40564d82df\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000348.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000348.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000348\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000348\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000348\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}