{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022T5397FbdS2ckOJE6jiP5HEIpk2jgixkSSQB19E46E4D9pYByyCjk6R84kw9b3gU\\\\\\\\\\\\\\\/Gp\\\\\\\\\\\\\\\/WaTRJHwmYq0P9MERxvZ7\\\\\\\\\\\\\\\/RYTqcIlceQjloy4aMLk4HdoCGHN8sze6xaI0PS1YSdJF8uFR5jFSDIhfNrWabjW4GKcZ\\\\\\\\\\\\\\\/hW4cmrLsMKNRVUsXVnd25uRndtOFspDy1xFSPJxFN\\\\\\\\\\\\\\\/3d\\\\\\\\\\\\\\\/l76lqkLOB1D+bigiTL\\\\\\\\\\\\\\\/VuY4CZETj6PTpBeO0N45flUKH\\\\\\\\\\\\\\\/jgV09Q2lpJ0l\\\\\\\\\\\\\\\/9u3k6sKFUXF06ALcCBkHsHxQ2NI6AF1vg0MgqRb1oA1+WRKcUlpjLlGZ9Qto7FZsXD7XHh9duxaRpOtgjimHOmaawoZmQInAQkw8mQWMFIyk2N8Um\\\\\\\\\\\\\\\/Oy3uZETVlSvfUB4t\\\\\\\\\\\\\\\/2H3Y4HtF+p0e0H4NQhV9lTDNxifLWx0kUGblwlDgl0127W518Z0ZTq5VAkozJv7014\\\\\\\\\\\\\\\/UMYDsPPAQDrn2IYdIFAU0hDkSrrSeMPE2zmLvqPN1BNPmp9ZHoFRnMQXCdUBikKS1DlQVigNqS4tWkdKk6nh31R2DNRTTB1NHN45m9f\\\\\\\\\\\\\\\/02I0YMhZol\\\\\\\\\\\\\\\/0iywfI6cJImPWFMHdVpBS\\\\\\\\\\\\\\\/Kb2LoJZlj6KzLHVyOFnJNYlS5Ro4i2BzN6bW9KnvGD6V5yWrXPYTzrGh\\\\\\\\\\\\\\\/TkszsfXNaMi2T57G5yut0Hvav\\\\\\\\\\\\\\\/IdTtAFQeHOIH7o4G3DTlRb34irV5StOFdQradsceuNqEb5dF\\\\\\\\\\\\\\\/3PRokrhfpq605RyQn+zjHnfYFrSkpbDAqlpNqUN+xq2ehuEjQCtJvc8Qb1UzKxet5OGnPtKcAkLyoYv\\\\\\\\\\\\\\\/rgviFVTA5+db07vPsbZHERoaYaKKfmIFmlI3yIuqkNH4aSAih5g2haxVe6lZtPJMnqxu09biMy09re776AvBXFRdn865u2X7KuY8Rqz704Auw0cYUA3FXNKJoGcUyvUItqTutGx4ft+VTycEiXy6bsmGPNOPOsrN51gSEUk9t\\\\\\\\\\\\\\\/JfAJIkwM\\\\\\\\\\\\\\\/JhrJifZu5FEulixH1OWy5fItKLsT34n2eYTig6ibhyxHia3VK3jJ+9epHL3t4R6x7YtuWewE7CMk4DPSzINfzLELU5asrBBx2cu629Nw0YlZjNGCL2OjEdmpwvb6eZb7h5oRQB8Hd2qPbEUPWk2beL1W8r9\\\\\\\\\\\\\\\/A62JCY+gYr\\\\\\\\\\\\\\\/r24QiOZLIynWFT1bY7V65u5jr1YZs6lmJzT9niUPhUgF+YUTjVs9SZBIn1k8C5uOLkowBtxQAC7wlaN4OVqLvc8Va2OQE4G1pfyM9wwHWBbjtP0ze0ERLfqfF3gjg+rMfhwKDF9d1rYFefWtR\\\\\\\\\\\\\\\/iWSylM\\\\\\\\\\\\\\\/mJAC5OerF\\\\\\\\\\\\\\\/ueY+Xeurx7Kalbxd6aT\\\\\\\\\\\\\\\/XZ2rc\\\\\\\\\\\\\\\/gYJTUavyu2vzMQUuHKA0tncUHbTg4t69kvkii0Z9wxZinGD1SdbRpL8DkqCuWKFQY2Vf432Z9rJpipelCkv\\\\\\\\\\\\\\\/GUqyzwaN8jYLx7ChzlvVE\\\\\\\\\\\\\\\/H6hHQL5dc4HMA3bAh45HXA4kkUK16lpo9bGnhxZXDoAruD0dJZuwo8Z4B7J\\\\\\\\\\\\\\\/uTeKTW1qgzujWI2o9mtFjdrIg2mZECVAYiqjGfdbDs1ZtnMXOF\\\\\\\\\\\\\\\/Pyq4B9ErUIEWyQP+16Rc6rcF3qI3GLyfUMLv7QtPIF1sf9CPAkQa2hyJe0I+9RjIrr3Oze2lMn9V7HqjezZl\\\\\\\\\\\\\\\/7pU5CJIRIAaNL4SbRrL8TD7k3o1Sl++iUWdjn1EhRJG6d84MVJE0HHLJTbnvSwdwmkRX4CKYawy4StsW857BbvqDYmX1X5N5zxVmLtGhu0lKf18suu9t5m3e57SHfzV0sJcmDDrFYSo4uz\\\\\\\\\\\\\\\/wbAlQSDbAe9odYxqUjrtgyOUHyovLIrnItCPmU2Cfu6vOYpI\\\\\\\\\\\\\\\/oG2T6ib9ZXWAHXxvhY7DLZa3q0l\\\\\\\\\\\\\\\/glff2bXxS2Nr+w0G3Ggeiz2fd9mQ9eCB39Fb1oS\\\\\\\\\\\\\\\/dsaE+r\\\\\\\\\\\\\\\/Alj0Jd7kJgQzMShMpmCYb7lXQ8oEIoRp7w3wIBlhhhHSJLUtAJXyNS2WcKyjuGqNfAErMfrQrt2RO9uyDA4qTY0I6ZlgOTCTdLzOkiDBKIDkNFhQNHOuQvKOzrStAKJE5G+C70g\\\\\\\\\\\\\\\/AQFv5t\\\\\\\\\\\\\\\/rvU2k7dd6ZjXPe7RYjPeuW6LkadElD\\\\\\\\\\\\\\\/R\\\\\\\\\\\\\\\/th8OiqOOTqCBU85MgWVRcmFiZxKYAAUNLKMcnTAekVwLyboXAiY8CbQdbDBP7L7rdVGm9JgyqKbLmJJIQGILj9O500vgej0aAJeR6HCjPM\\\\\\\\\\\\\\\/xBI8aVjlhSy3PmcBJRekTWd\\\\\\\\\\\\\\\/6XW\\\\\\\\\\\\\\\/NoZ2n3GHh3rNewpOjUmQDZXQC3M7gglN+VA0Gs8won5hXmWVRU98aRTvyudrWVWVmJHP1q8SnGAg0+TlNFKdhyhZDwnMldOGOpAG2\\\\\\\\\\\\\\\/lxrXNaoxqF+heIqOoA\\\\\\\\\\\\\\\/VTtCkKijRleYY6vy7hMvoJLbZQXK2sQUZEZxdjTsqxN8qAmr8a4bWI9bz2Yh0BU189kqVnYY4hpAGNwd0emIsn+OzovDZY7QklTNYuf4BX3Me69Yf2\\\\\\\\\\\\\\\/ygiY93uQwsu6eqmNpGeiYjqalScOXD7FSAdn247UjYqp6n60D7hBr3Ytvaa1WLli8AxydVnHeFTdE1ezzihZtadbu6hod2Ld6KLitdiO8TWm9T8kTV+3AXpT0GwIqXeQBnOa3oEo8NWv6ZDfQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022VJ1inkHEz55V\\\\\\\\\\\\\\\/qB1x7zCQQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002292407fd9660db478ba4199491f1f55a6fb4d0bb3720f343915cd67557e075150\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000624.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000624.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-000624\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-000624\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-000624\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}