{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022uT29bVFuMaxFjwyi\\\\\\\\\\\\\\\/+V6NqSUtHvR2OfvUozOO5ESryEMz+thFNyBAhqfGXeHbzzN27i+ehMrfrXEqc0HpGK6Hxb\\\\\\\\\\\\\\\/4uRvTuzaesaJJUowje\\\\\\\\\\\\\\\/MPPoX14Z+0As0tS6\\\\\\\\\\\\\\\/STR5Wm1OZpMivmVQBHCoO7T1+hsxRqRzyXoQftRTTbuy1xLmr32ofCNnP2kkYXGDePNZ8FiWFaps8AuGMz2ZxMwZGvmGOZGalqsGF5LQz0vexsHhAh\\\\\\\\\\\\\\\/uD38m1AVGXoqR41zIHotyWrEiyl\\\\\\\\\\\\\\\/rtsrPQ3mGxxAVrxRI9Bn60iJdrgL9ytN35ZSsyYiEmnxm9RiwCGdRYMSdbsnhn0bNYv60bnUQVbK4Y7LUjHEdbC9sjCbpIlAQDDSNEvVetJc4lQGIGV0UYmJ5cuP1VSs32pWkJ181xj6JV5bwCkR9aIYXo5At58zGgKrklw0fDh3fqP2k32t\\\\\\\\\\\\\\\/u4mdFmbJdVYo\\\\\\\\\\\\\\\/a9s+YEdEvZ5mArx9Ipz9Sf5zhdhWW2MEQjvAyptXRI1dYvvPiN4XwYTtnXTs03\\\\\\\\\\\\\\\/wQuGvBvoe6XrSzr1aF5rxeXdrWL8Nqjss8H2RjqxuJDQ3+JbvPxoJEMTJmhJxe+NwD6v+ZX\\\\\\\\\\\\\\\/z6yYlojPBxsTPAFnJsSHrdk44tcGZhyGNpFqUmI5TOOozBNWgyvIbuXM2OfL8pSFBGzBqkBAxSi8Q9w31pudjwI9wyGyJkish0erdEC1+MkFfTSeyNT+Tvr4o4X8gi4FkBZcf2\\\\\\\\\\\\\\\/MOLiiQaY2LSfky2\\\\\\\\\\\\\\\/2lb4mmapMqdM0zZlXDVVI33wgk8c\\\\\\\\\\\\\\\/tuJLCAqA1nnXe5owD5Dxbl7vWk+drIgx\\\\\\\\\\\\\\\/AbutGgij1DI30M6EKwAE2WgAShdm1g8glbyqaY2ymUwe17brSCDIFPIfeMkZ1pKzxOC1XYIB9Q4Vh5j7cjhgaMXQWkmKO8BtJqh6Fqjavp0WA\\\\\\\\\\\\\\\/fdbo83pH2V7JYiaCuJH9jBRuIz8+srXJwh7zgPOwMGUcH52NNeCiWt1WUHiejuve4DmJIz99mD6tiXs4vkYsS8bJFN2lvCKnEzmR9vLyA74THVXtH7\\\\\\\\\\\\\\\/enl6Q34m6xyFoydsmmTnFmDo7Er4\\\\\\\\\\\\\\\/qJl9N1kY3hp2MSRLdGjbHS2DpSJjEj69mTHYBeqZTdx3xGCptASetuv39fheBLgq8rxuddUfU7EROHoLNyZ2JhfYGW4gDg5ixx\\\\\\\\\\\\\\\/EX+lq2maU87a8xnU5UK57XbyaVGM6Bts0IUvAWEe9Bix8IkiXGGQ5NcbYOwIUT2spiLgO31ArNObKsb+ej8iuNeN8+npa6s160w50JZTAufgFHvIR9H+HrmjVYUarhQ2Gbbfm53lpI0gi5g8fP11AWHTrdEYKEc0ggg5UxGr1EeBEzdD3ihNKODewFO1AuuUsMXR02Y\\\\\\\\\\\\\\\/RvzydeB51+Dwltpus10nVXj6BcU2myXg1UG0VdnnlfLjvu7fPXozF64GYHgktYYMlpVRQwtzyVhdN7T3RIfTABIz07n\\\\\\\\\\\\\\\/HyISqZQh8hH2F576MUteZexdsK+p8qR775PkFHQh6L9xk305vmYSE1MnTEX65BvOotoAzfVycGKQXc+VjL4SY1pPthPqDbHZSa1gpoyloi2M\\\\\\\\\\\\\\\/VmufsvzCLIocmbvL\\\\\\\\\\\\\\\/YqsyX1TjNGUCNbSajS\\\\\\\\\\\\\\\/f7gPAV+Ddf\\\\\\\\\\\\\\\/f2PnDprihu4dukH4g6cl6sRIqK8JY6A2lXJeTymbRP1r75\\\\\\\\\\\\\\\/6FMwb7tsaYPMBdZarVwNu\\\\\\\\\\\\\\\/KS3\\\\\\\\\\\\\\\/3R9Lwgx8Nr9rrlnujpYFrSEOF\\\\\\\\\\\\\\\/J0RvTq2U\\\\\\\\\\\\\\\/KgwBDu46cryw8EacS11t95N7KMNSfhUa\\\\\\\\\\\\\\\/zJWXctQNpMiQ5UbvvY3H85arKIH6Lo7XA9RK2U8+NIuL3XPZBfJkJNMsedwJupWUgQHP5\\\\\\\\\\\\\\\/1AZuFfkutUCtjEHB5MGhXMmCurw7uBTy6280M6DjvijVDT82hEkSLnTmGA\\\\\\\\\\\\\\\/BhSu5WzB0Cz7saftumuFMINyCfFzDsZzAMVgBV7DRDHUuWpf2L+4iGNEH3PCi1Cq+31R\\\\\\\\\\\\\\\/jgjIMLWAZ8KhtzF2vmc\\\\\\\\\\\\\\\/rwygF9KS6P8NeKXvTfBcnbT223QHHqJoaRBUkVXd7df4vWVqIU2yRZ8k7lNruEePdu5htAeeKlWWy+G\\\\\\\\\\\\\\\/L1cp+qeIrxdQZdPKgBsMtwSIXFT8T1gOe8W1DBNpZU224esD8cIo4aa1gOzxxRF5p9RteW3wljDzI0zT157YFZHsIAcbcPu1t71LD1HNL2mpg6u75\\\\\\\\\\\\\\\/gzkjFbmygr0wRbs4fpza\\\\\\\\\\\\\\\/Nk8QJ3TjP11VbN8uFUfXVclMs9uxji6uJiK9k7jY34Y5b2zZKXLiWqK5JnbjDto9U\\\\\\\\\\\\\\\/F0V\\\\\\\\\\\\\\\/Y2MvILK1M6jGOJkfvtFAXkj+6b24B6bEZNF3vjCgIWS6aPFp+ZU6T\\\\\\\\\\\\\\\/dmL4bhD77VU7RKtpVnGKmtiV6aBj4wzGmt1LsoBWt8H7HR12lf2gbW5mhp8uyE3Gv7LjZJDRAKtEPUF1z814dXebHBJPqmrqrEjWk98VlYO5tilNS53PSuCv3Bi6eWHINoe7p+ARmWLcpywaxyH4NBHni7NOdRiWHG44rKsCfl7ZJV5YPBttZhmEDKaTUVDow1o36j\\\\\\\\\\\\\\\/A80b3s1+NRJnkFxPo39Hwb7m7IjvtrqcA+zuL2bsaIPD6e4bFNrsXFdJ+xZDx06b3lIHN06nIz8TWw9MynErDW3ALkTvA9WA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00221ikyQGx+tBInfbI6NLfSdw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221bd862ec8eadb58daf84abbe5495ae6a6614c86d5f9ba62142af01ff8b15d340\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000742.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000742.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-000742\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-000742\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-000742\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}