{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022wgAdXxK7oFPszIl3rjzsOopLE5RIiifEjqQF20dHJontZ9P06NSGVfJ2HH79XGQm6w\\\\\\\\\\\\\\\/HTfw0sl5c8n79esR7f7THLQS5GyoEbkgrFvqwrj3HCVAuv3SVDyXUjPTiH2r+AhxfquMdT8c317+8Du5MRBkyPW9mlJ38t\\\\\\\\\\\\\\\/fTBATVPBNBz9ef9BnvwNke6r21jylZU5oqO\\\\\\\\\\\\\\\/N8L+lsaJZqBMzUY+L12p5+et2WgXS\\\\\\\\\\\\\\\/lYAjNKCbhsZUveXQV98Zn+KcIdWaOksgkIb7cuEjEzlGtvMe9UuzLhx307dJiIBDYRZAyZL9ecyovLx8WrVNgw86Bi4lSGxSToZlb8UQ6qdq1Pc9Df6EtYjpWUC153YmAx3ikscS0f0XNk576v7HNAPEjqiAk+PzKTMDjlBR\\\\\\\\\\\\\\\/wCVGq0\\\\\\\\\\\\\\\/Zo9DTeHSvwpVHfokcFWeInbBsLotmMKJogX3QiVXSGCZyb6IV7XH3Phhx03NWx8ClzTxa14OORXRUdGZT0XWPlAZljnWNOvpkGESZp7CmhyqqTXgFDq6bv8AOB2zIjO\\\\\\\\\\\\\\\/np0Sp5WXbYYfgChJnHT3JxQR7LOwzHwnICu12sP2+Xe\\\\\\\\\\\\\\\/nwaqqHHwHD0ZAZAqfUGZWygMkm9IuNEHUKlfu48\\\\\\\\\\\\\\\/LuHI21n2IXWciGKu9\\\\\\\\\\\\\\\/UMAzk9bisI1Ey3mXnAnH31AwlzFEykENZTKskw3t+TZVn3f2Tjp2XSnb4FFdpb1HOVDfWiV6qKHB0OJVi8qalSYnVzD7VSc0K\\\\\\\\\\\\\\\/PLBjqp7AOUEqUtj6yWRk6NQWLxId3qav\\\\\\\\\\\\\\\/3ztSacN6GrEabAxxi4Uk1yM26nJPxYPiapdNFnUGpgtoABL8E+Ufy2QqFg48szpF4qsvGbhuiXIu8ndZnn4STgolaymfCxbW5LZfRd0gvyCJXTNFAcsckV5nuB03e151mSkdGTkVkEOQF6S9lAGtfqg4B41RzDNa\\\\\\\\\\\\\\\/VaMr6Tl1uSepWkNuo5CswJzm+PxKJbWaZWz9s128XPYyCsJdoOcR8yZy3K0+GwXnp5eQqAsJCLmPQHarZfq\\\\\\\\\\\\\\\/iwyNSBHItDgi4Zdbjkb63D2OpiGqcy\\\\\\\\\\\\\\\/tOl77JIGSGr0x1TfKAIR4iN7yr4OqtxRAZY0k6C6OcjqWsCkFU1Eew5LXZGRdUdAk1tQk1zXeF+LA1DNnEv3wMWyGWuvOIY0GVSJTJkERERXUZaJyVYy1Pdj6urxHAXE39e49ZoxdQqkyVmJjqkWTVSu495ilUXG4CMi5ZzGJJcBSf1VX5I5\\\\\\\\\\\\\\\/xkWuZ5v1itg+wt93xuYaeiF\\\\\\\\\\\\\\\/B2eChHmDABZZr70e\\\\\\\\\\\\\\\/NZl\\\\\\\\\\\\\\\/YFz3UmRBWsxLZPEwm55ZL+9Uv2wN0mgsmXInrchnKmNBRopNCZq1N+qgE\\\\\\\\\\\\\\\/oaSQtF4yqY1nrg41mNe6Q3kIwdyRoQmJoGvsjo68HBtAKFzgXcSO96+vQX+RYNJP2s5dtjWzPDNLLfETlget7vEHXOuAadaU1WQ+nnqf3C4eTU+HYxJTGqjHqKFatD3crSAbuWipcSqmftgeOfYpClUIb3mhrGVOdd8YzL7u+JMs7+\\\\\\\\\\\\\\\/5cVLs3ARtxDT7ppZ\\\\\\\\\\\\\\\/N6l9hqthve0PANu2Vkh1cJYOk0WRKUV1MF+IIa6ECwD1kDDYefWGIFE8d1KY+OGCdKuELS5KJMcO0d2KKPbwqZBkIXps2Cat+w88sy3dx3IrW45HX2WyvNyvyaAJcI7blD3rhZRYXGSrHhfv2XRD0QlKkJYrKcrOItCovy3cVnA9e7813jF9vgmIzNc\\\\\\\\\\\\\\\/ZdMsSkkXKk1qk+uZJyOmgNQTeXYGn6CC8558Xm5zEFfbzLCcTmFd5Ml5y00W6iR68DZaFa7Xr\\\\\\\\\\\\\\\/duz7pDC6TaGA5SZtCH2NvJCmKHQTRL+g77Mu6jBgemhPz2AILdq\\\\\\\\\\\\\\\/mrcNdWPFVLyAzH2zxNwXcMCdtK\\\\\\\\\\\\\\\/p7ilGc4im+vTPoDJq79xxxzgO32qF96Rr1fxee61JsgTOVkaQt2n+xYZnqft5D0viClILqtqpn+IRN9zofVyoIzyj4Wv9744+fQUmMS0GDHbiLaX36guNNFc9qxZwnQbG2XIVG4s3DzsFe3rqRZu7qedMveP43k2WruDgT3QQW9h4Zzi9CaOWMXlJDmclu+pykOLcHba8GcnrYVF4\\\\\\\\\\\\\\\/3qMR+MzOGeCfmVIis3O5m6zPnj15uQaqo6ElWPxQdjmHF3Z4SL7nn+wcgzM55A4WUS2sUHdcHgkjyDMSX77gfPxD+wTwxyUcFv4IgoocLw3Xq7j8B1VA5AW6ER+VE0aYbEq5f2nvmkst6QcVBIIHl3Ee8M2d3EiG\\\\\\\\\\\\\\\/8cwkWTT\\\\\\\\\\\\\\\/EQLHmgQQjx9Ir10SBqBy5eswNFY0jf7gyqDXpXPiy236BuL2ddjtvOvud5OzlSjQgwH3Z9PmtuZPVmGCCCAZt6ZV2Scp96Jx7zvJU0FAK73sz9FTl\\\\\\\\\\\\\\\/YaqXFzurFVODflEFfThZclAhCSwQWjGP2CYh+5YO2hOmkybw\\\\\\\\\\\\\\\/1e97N0p+Xd1bCIWpiBsWJku1HbsfU3zYbhrdF9L\\\\\\\\\\\\\\\/qu\\\\\\\\\\\\\\\/PJqGl88v3\\\\\\\\\\\\\\\/MWBKajHShxsWqIxnCG8NZjM5EwWHNjnYRbKt8r2r1HdEaXbQzb5sgzPZ2t22UKT3FAij\\\\\\\\\\\\\\\/fu+hWyqsxqO+l5RMC4yvP275M2yniEPxnUnCxgSadA4azgwE78zkjeagAroo273CjWjzruzV0Nlt\\\\\\\\\\\\\\\/GZNM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225N97zlBJGzeeWIcEqrecCg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226b9f5f4ec59c638e1684354caaab1ed4d8598f3d84a0032d5f621f9a18832f58\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000277.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000277.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000277\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000277\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000277\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}