{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022sksPsGzsNMIHmkIWMRL+QY8p0NdZW\\\\\\\\\\\\\\\/vG8MNy0KEEC1mOfgtgDMmisSn9hI5iB81+8xlC3i20h9v+2OU6Twtwkwwdg\\\\\\\\\\\\\\\/wcMhadcLpSvtWszA6wGe7Ucce6MUnm9WH2sXw3NnvvYb115ADkgF9+1\\\\\\\\\\\\\\\/VDSbsCnYmTPXVf+f60zZk705GCp3dv6CbI+WrN8lTRrmTzf4B1L+XeWvo1kI2dPZ8tyaWgVW7vPBtkKq6QQo+BuGhXlC8xbAcIMbKXrs5igiBfwObpXedhaQeGwCXuHLRTCiRhVTNmeZN3nhxiq95DMk3hJdF6dQyzVbV61tXmS15lH7XzyDTFyWn0fW9lYHnGhCA9O2ngpGmpy+WfhSg06Hx1tS\\\\\\\\\\\\\\\/Ijt4aIfo9Lv97w1lStDuje0lhUzozqwT48NgYchONGjDdivV5b86Oa\\\\\\\\\\\\\\\/NXS3CXsv1XF\\\\\\\\\\\\\\\/jB\\\\\\\\\\\\\\\/AKtFeDSisXx7ruLDkFLxEhTGJcfGsclsd\\\\\\\\\\\\\\\/+ibVWrNPQcB7YZoad2rfJOrblAcQjPwYDCwXyRshSnIglUsMk+7V+460RNltyHs7U1suWoICL+DYBw0lmWiqzMPrh70Y4nevF7n8ikRY52+O5zlBIt8hcUxCabcvIyT3UwShQJXIiTYbQnH+DIxdgGwL\\\\\\\\\\\\\\\/bNbsMYKLB3yEwjR+BI8kt2gkxxgXDSQimkiPsAtwQuEt3db61gRFOoYwE8MSpyBbLMKBEE68OzEbzACVE6UGNbMeQbYaDGdf+u7tb79ydd3IrhwjVCW+XEiwUHck63llM9sb+FkkptCwZ1S3vFLOJLix1TbUGi5QKfGP35McYETy6SMnPlnPU8ttCPAWGI5\\\\\\\\\\\\\\\/kP7FFLWM9VYiHQdD0MuQF3ohZI5yli8Nhcw4Bu82S18f3CvYfd14sGL5MPphS6Qb5oiMGFVsVrcXg2SIV2JzsUmo6Noaq2LpONBgDaZNr+EJBGPVHE\\\\\\\\\\\\\\\/maU1g+NOx+unY+nP7DSjh9lW\\\\\\\\\\\\\\\/O5lGzBfUB27HrhB1SHuzz4p9rO4ChLVaKe83n+3yUnxSkKMxG5eKCz56+3XkU9mj99IIbEHiv2Ervi3GHiHEdkYKOsaaWhGLDddTZlq6V2EvZEwpHT022sSTpn23gpMUMygtjkMbNt6u2o7s4JVdXGOPdlKHF1VFyqtSraXd8bs3\\\\\\\\\\\\\\\/xYRBcci69tGaEw\\\\\\\\\\\\\\\/9mArD5YauKR+2vLu15UqHXFa5fUy8Mpt10mrgTV1A+lkfupF9E5Q6HF\\\\\\\\\\\\\\\/HhTKNMIr9qixRJSjehQkdGBMGImHzf\\\\\\\\\\\\\\\/4+4LtnGden6sf0mPqwawJn7h8JXm7mA0vbwqGfiazjpVPbHwtKE\\\\\\\\\\\\\\\/hvIfu6BbJ2bJmv3BIrbdVjstWgOjKFFcM6u2jagfXgEAmlRN7NOIYxkua7OQiL\\\\\\\\\\\\\\\/kOt9g6tqKNIGqyXolWnDpYccbLSEhft9atq8bVZz2RFNM4baSpbZBAQ2TpGllZsWy8iN47FUXrf2t2JKGN70xcR4t9TmQVhVmmuhdTLuiyFwAcFJWAhtTugwqNgiWckacKsnmygEZ\\\\\\\\\\\\\\\/s3strtUBNvh0fyPxOW1ga0cyqDn\\\\\\\\\\\\\\\/syuR8Ex+zSicRLt780WUh+TaR2kcedTcyobigaf2cy1xz1VzMFXrJQu3uW+unuLXcEl5yHvfYbAeXUYU21vEmF23CufHlQWCuyfz4AcbKbBQ1KW6toGD0VFS10p0RCbQsAmxpFYjLPdTvRa08iaKZUbO9IMK7WeFyROsuNPkWXbyrghU\\\\\\\\\\\\\\\/dtHpQMd1VSD+Lw+udbBAc8VacGAdU\\\\\\\\\\\\\\\/Jw9MYvZGVP+TBSgngL0KNY2ob0NwL5VzZkIaOx4tr0ZCMpRz7JomNe5YMsomTB42AFs1DwebmVryAvPp\\\\\\\\\\\\\\\/epBBRLxiSJP0kpaVk14hWyUi\\\\\\\\\\\\\\\/olbhGRNO1yN3fUXfArIHSa\\\\\\\\\\\\\\\/M5cVPL2S0D\\\\\\\\\\\\\\\/lqjbcB2wH+jED+YKJ4jsSzRRPAULwnC26fOGc0Q8HD0cKWHKsBCvku++Abhb7RXe\\\\\\\\\\\\\\\/CWaB33FueOwDQTwuEmKOiCbUtqli8C7MPhvtnalHdZVA2CAQKxslDRIxSfKNq54VqvKsoYkHuXpSzme1WpvgXPMBtARxn2tHezJKYpejTGULjJaByIdIzkjurVBI0GTwK0d3yMgaFcgC3kUN6XO9JJi+UtKmahKt3SVGGnoaE\\\\\\\\\\\\\\\/+OqJxiBM+V7nMofrBx2gp2oq3zofUDn208qRHGci7yhHWFNJuhvlyLFii30QMAIQ9pvCvtYChgrt2sEPYFf25xcgNcSPi1ub9VovLJTUhWzqPpiE0S+53Jb74mSV74XfkD+fDpLTwAVCq+LhQ\\\\\\\\\\\\\\\/cPoGy69nBBDrrmzbx\\\\\\\\\\\\\\\/BesxUEu1ZFm3vFxzk8wDZ2m7lU6tK8PiKEONM5sWwSKH12Y6SudDYnUVSMcHCi885MtiwX8R5o9omwoMePx+smsACmOPnYT76KVV\\\\\\\\\\\\\\\/KpmHQvgaWC6IjThSV34w++TCvO438SqodKqaO5gltKEzRHo9BOCJEJJ6zEgVD7L78Oavuc0\\\\\\\\\\\\\\\/zkDfIPtuAFxjZEzzI8yRwGRmsP99xGMoaA+F6b6Z9hUCYKBHfxSbecFUx03upQ+rBwO\\\\\\\\\\\\\\\/Ujz5M39V2wAR\\\\\\\\\\\\\\\/WKQ3uZpbUqAoK80jD0sAHADjVrA5+pwh+yYq+UpmgDqLdlOl4KUSA54Ed7yQ7wuZP991ZYFvO8spxIsp2HnRU9akEbg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022nppLRW22tJYdM9pMC73Yqw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002250474b943d6f23eb19cd36f907867abf103f28a6933a59b7c7dc6f026a791b42\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000345.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000345.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000345\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000345\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000345\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}