{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00223Rq\\\\\\\\\\\\\\\/6lvKXJA\\\\\\\\\\\\\\\/jSRebNaDxPPAEdrqsQ5PkfFy22pIaHMA1nPaem4SZoS2yMPx5\\\\\\\\\\\\\\\/dGhAZ9HhTTiNbQH7p29wW80xY3n43TPCxfrUfSazmQEzD\\\\\\\\\\\\\\\/vZo5h07NuNcj8SG8qA4nr5bZJtTni07ISjSp+oS+T9TDiWIU1gvpzIo4KPOMMZUkzsrK4WvaAwrRCYvwKEj6pLkRrv\\\\\\\\\\\\\\\/ri\\\\\\\\\\\\\\\/yRc8vURCy0+LWZ\\\\\\\\\\\\\\\/nPxe9GjyfOKcuCwgE+Vqf85oozzevhANfmYeAutg0MJ6w7+FA\\\\\\\\\\\\\\\/9dATMXNA1UWFYSBc0g1OkXf3x1RkNL9Upe\\\\\\\\\\\\\\\/mTemxeo\\\\\\\\\\\\\\\/7tWnmutKc7jJw\\\\\\\\\\\\\\\/rjCExvlNsHc1GaTPPVRoD9Hmo33PQHmZySly+IsJpedZtVWh9dvOEYKlkOWUQHd4zt2avLR5B076OPefo8yYzInr4D60mLlMVcHqUyQjyxB7F1sQmqnQ+cjTA8Nrda3rYnYs96\\\\\\\\\\\\\\\/DQzVz64YkWyIngf1Rr3fgUK7xv62YfGPT7Gq2InNKw2MWGW3ouliuKtchmaIxdeo0RuUq9BWun+WjyW8lhUIxEli9O8KXEdJf6Dn5t18rjszUCklGMLJCQe7qrHzBuH4gxyc00p1npJOecydg3LdpPHgA5Ww2B8jhkm7+cTeCM+OUzw1vg5sDfaWREkRG7IQX44\\\\\\\\\\\\\\\/H8aZCAX1OA1dtJT8uVAQu\\\\\\\\\\\\\\\/FKRQMv2v77WiPQLQD5X\\\\\\\\\\\\\\\/p9ro+zFeyc0exLZ56Sc6gnnvzdCp9d16YrFw3j\\\\\\\\\\\\\\\/lCH4yi1uhhLqbg\\\\\\\\\\\\\\\/40vWdU7td24exlY\\\\\\\\\\\\\\\/UiwCGSqr+aubWL6U57G0UT7Heu0ezg2n3aq74Node0IRjBj0JnKh9BbBBlMHGzZ2RV\\\\\\\\\\\\\\\/nVNNttmPzHXZFzorBP1X3PkEnrb6PgcNCLG3ZyGTUeSRENtbgAXl15zbl3x004DVf5oneIjuuMSVUonciyPf1k4VKwSq2gMoHgdgJQLqslBYFxilYvIBSdRxmpzfaC1A72h94kZQ5RUuvkRo5ML4bphtYv\\\\\\\\\\\\\\\/CyDOgnhwOz5STr9Q7eKK\\\\\\\\\\\\\\\/AWpnUFl\\\\\\\\\\\\\\\/r\\\\\\\\\\\\\\\/DGgRba\\\\\\\\\\\\\\\/pVEEnu83\\\\\\\\\\\\\\\/5Rm1opQCqcl44EYoHEE8hvfIlMvjylLu3Ss9Mh7AEreDA2z+aA5Gu14SgVzMVCaFCI1ikXYMYC9oLqV+ekfh3OhpQTuLrU9tLcIWuvWZHAPFicEotKXf8vfhBaVA73JizUtBBZXe4XhDk5p3JgVBTnqpAUsbhgcN+9r3+sBa0UFpaQzEfdJozQbgCvihIzzuuiNcA2wBdBbch6OGg2J7VnGivVCSWotTW6U2AO9pUywIQg6UbecEhZWLKNE3juZT4BpFZql\\\\\\\\\\\\\\\/ELWWJiy5Ye5ytkr70iYyzO51wEeERaSsvka49DGNe4n7E6PJUelztp6DafGl8qvbIUHHSD4uBcz+7vXCJ\\\\\\\\\\\\\\\/k2IDF2eLm636+zm4BFhcGRmXicPx0PFCaq2Ww4YkFZK\\\\\\\\\\\\\\\/IBPmC264lM4RV846LGQR9kxeAdIFU5aHIia9cQKVtk8G2kmybub+Zu3UPH5aHMj7bPELMAAoxrNHObI0elz5\\\\\\\\\\\\\\\/OwV2blAsn3+5xoETOHOFF9YEL9L+ZMZKw7clXV3D9o+dpWpw4n3w7mtIV69qLr598nDQfLQF7XMVMj1T8Z2ITQsVVzAPNRPzcc3ZpP8g6W2h3GlE+vVqjhJmvYV0zh+6CW1+qzatrI9wuJiCCwk9PisyizPWOrbr4DS7ok5NA3yXmtiJxK8qvbBdy9GGUuvuIS3L+VRuB6y8RlbHBjDi2XAzEc1\\\\\\\\\\\\\\\/yMrTAADj+5\\\\\\\\\\\\\\\/ZebZyfRhgGDUkd8feMc\\\\\\\\\\\\\\\/7KLJ63Rti0EE6SIfb4YHShso5ctyW+i2ubZSmRM8hoSTVGU6x+Z65RLRlmPVxnwcekVVjh39SPKuvyi7nnCu1HT2sDAS1vKcLZ406HwTHAdlqmqWHsm4CkDhrlJ7FWK44OXzFrn2EWaj8Q0xQz7RGwkOeWWYpZDpwoc9g07DJT7icQLgBB7JXV\\\\\\\\\\\\\\\/Lhewlj10GTEGha5HcNUYBol6EZNQXIhf3cLn5IIH2GHjJhwsAYq2PybQcY7OFn9ZbwGufVHfvKMRgWmEjOSIErA98WAAX4d3CJ4qE3\\\\\\\\\\\\\\\/cVv\\\\\\\\\\\\\\\/LNM4U4\\\\\\\\\\\\\\\/0fnD5gnoikQ1n5tU7zta4Qe4kkdw3c+fvY5fcGkQpUDdak+QK0edyfolB+U0YKxFCbjs+0IOm8RVSeQ5taDBGZUwbXitYW8xwLDu4bzz2z9gpW3HJcHe3S5A2L5uQq\\\\\\\\\\\\\\\/kjXFMlwYc+WcoymOUdDNN3+B1V3cWXvQkou5\\\\\\\\\\\\\\\/oIJE5\\\\\\\\\\\\\\\/2upwPItnSk63b5e3px21oK1DkHYgx3qJntSKdaeb67UBHBwkIcKGQAQweAsGBtTvwceampIHT4NDUncC\\\\\\\\\\\\\\\/c0\\\\\\\\\\\\\\\/mlOWOhBNzwRyjrbRUeoxcHyWg0ZJ1pue+ACLa9IKDZ9efEFhY5MG3a1pmJKMA1zqfvwtGMjv8G5HTJXXVNni8Ffy27mT1iGbGgBIAEAG0Lix74O2BlD8ZSIOhGVGS\\\\\\\\\\\\\\\/htp\\\\\\\\\\\\\\\/BEHiCdvGT4I2jXxNDSE3R6yUlC0STrBJOvGWvDJwluDFP8eNXWRlbDQkxisd2FVkphnvqbTagWwOKje1MuH8M+FWeoFbv3CwKitXo0nk\\\\\\\\\\\\\\\/jJZ0imvoQyr1leUew4BwL\\\\\\\\\\\\\\\/wDDMQiOr+JarwhY49MN7M\\\\\\\\\\\\\\\/kDcXWvKtVm8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022PeSIsNmdxsCLti8lpBGa9g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226c718b54e24d47452b1753582ed8ef8943ab6bd28ad182182ac8637ffc4cd6d6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000610.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000610.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-000610\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-000610\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-000610\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}