{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00222OdXav55sY6w2xuq76jEopvLSUBwrpqEUHmUqoM\\\\\\\\\\\\\\\/YMrIBnMxO\\\\\\\\\\\\\\\/r+rdnNRsfR1s77TX6zKjerxlxOYfaAxQ9NVlxJOEEclVdi9c7SHtLxnefQlRL\\\\\\\\\\\\\\\/q5rSSY5TDhOzQtWazHwgfzEeUD8eJcdjWMAxGkIV0R6QTTsiaU\\\\\\\\\\\\\\\/VKqwM60Tfe\\\\\\\\\\\\\\\/j1WUnO4VRbxTBME04cjMwPD9cOdQ0XVw41XPIqDzBJn6hloYpq10l0r0dCN9046WKMllvBnenp6NHbSS82h9jWZ8tlRdirsCes85MZuQfxjxGGl8xLpFrlMOBrbPcHeLltzs1A89aWCL6MpRwXlVhmvVe+aB8qu+nBYHYInuuRXQ\\\\\\\\\\\\\\\/ItFgc0twij9TsBHDDk1EJIL9+8SVUk\\\\\\\\\\\\\\\/cT++1PCsHDstupcCD2PqVoHARAX1HRVOl14POcdaBzfjsuxf121VumadYRhgs+r2q7WExq86rgMaK6cM4SiM9qCy+KVfe95eqF3oFHJuJZVlay5Hd2w4tbxOww\\\\\\\\\\\\\\\/NWYbPTXzbtoi7cOGwO3956JVOJT0EeAePA0V4ZQ5B4QawkZ3FbYZP4YQXlZln909E40QBj\\\\\\\\\\\\\\\/dJQ5nDuOcshBjvlNERZGd\\\\\\\\\\\\\\\/ZVQG93puZy2OcBjt39TEOxgQe1J+wJMsmZ0VAP00tFjZAzW787sjsHl7UR\\\\\\\\\\\\\\\/IzdpTwDgiizdkyBZ7RdIYqnHnWxKPZcm3z1aO5qHq8j5ilyy57YvxQTr0y5XHWnRv26iSeS7WKN67gSgxAXbM0PlBPQTG+wxd4ZSMVcXatWRaYIqmCmL6OB39kIWhoNPuDij2SGf6wGn5jjna4gUTH+v1E9osMeDmrLb4Dkr4DutlFrOMe3qAt3wV4ROaCcsDQNmA2SNn5ZD+gQaqfW7FRStWp6LG0RRo7QuVIR0nuRE+CHJ02f303rfe2UesoP\\\\\\\\\\\\\\\/AGoLaQQcAjoiwW8cZVt0dBGvfX3pgDWpeHoY0AUd9770YO\\\\\\\\\\\\\\\/vkAO3Oopu2RBVnn+g53+f6wt9Kek8ZjnCIdH1p7uQAKaTKZVfkv56vcqkMmKr2Sm4uKXo66WhQ+1ARcAyPgqEMS08hAMCIdqArM53vy7nfV4pqQ+P8AXvvbVx7IjWrEP\\\\\\\\\\\\\\\/lpvFvEpAMzsWgyzH8gOCB48pl7zKN\\\\\\\\\\\\\\\/okZb9aoUNqxiAgVfaxL46Ce+\\\\\\\\\\\\\\\/NpsK1RxkrsYHkPtV20x00DMKMBCow8lfuNEbKIBpwkLyAu9TGTgSoZGq4tMjsL0BVSGA0qSzrC\\\\\\\\\\\\\\\/iSVq0igA6BLv0ZyEg1\\\\\\\\\\\\\\\/qbl4VpvB6rbmGxKrS0sF7Vs721pEFkoPSgaZhshRn7xGr4KsnBxZZjiZOG\\\\\\\\\\\\\\\/c8VJMkhHgyHovyHlMSnbcbYd99tHltRW712j6gi83s5jbVVp693pmu7geS0o8Bf9WvvpP0rWNGKLbDcZLfw1SH1TvPqZpFT2RId0Om9CbegEqoIkTMYmHKx14z2wRfJEy6hs39TLbqNRSBQwUahRpvX+LhUXQQEsDR4nHSc3vcvXNmImxSbydzE1PRdBAr5CHQUkMXdbK8R\\\\\\\\\\\\\\\/Dt++KSVtbyOztfdD5qi5Y+faL5A63JqyqWW4uuXzUZpxLAChqhqUXkQS1sje2bIXn597peeqjqecTvy4qQKOMeeFa8\\\\\\\\\\\\\\\/P+SLhr9+gRPpPeGvmhA7VTs4\\\\\\\\\\\\\\\/zZhhLWwVJ86RmtHjsS31uc9URAU\\\\\\\\\\\\\\\/up3WG4+CX++nlyUlFqVBntbK0IdwxkVCxr+CwTnOJOiS3bbMlvjSPZ0plTzA9rkAI0P74wKdWPa+jtz3plO2i2k76NkTrzhdGFnJtgyFS95abFgBJMWSg\\\\\\\\\\\\\\\/UgeWUgKI16qaKmmMQqxBzk4hQILGOL\\\\\\\\\\\\\\\/HVPqz2XIOSxNIM9lCdl235QoZmeKuXG6EnykZ9VobZVTGM1XFsdB58Xb9NY7n7qtlbNVr7kAHXu9Jtpo\\\\\\\\\\\\\\\/Zr0NYq4TiC2gReb6heCpbKVEmgc0N2FqkuFSlpqauTDKLachPp8\\\\\\\\\\\\\\\/V2EEiR3dfUnMGzfVRkOBx7EUtXPKOl+KDfHRVNLFwPZ2cyUa6+RrS32Sqtu4WHPAaBe5JktNFmcVL9S5UoSOR1vaxEgHxvWfzlsU8ozs04okpeQL\\\\\\\\\\\\\\\/opcdo64\\\\\\\\\\\\\\\/QE+HyiR0nyzUjvXdyWO\\\\\\\\\\\\\\\/jDeYayZOjdo4YTcbHFXfwa9syhfURn3nw30pMyKHUpOlRl2GlkP7P2KuG6C+2C7TsqUxsYOV0eJZ8cEhOAImiBZgUEq0dodtzRCFWFeqGMtblXNNIKhiFF2IuJcNybPVgJItwjyqK6pidce9wTWUk76+43Tyh9Cx77f4tefVHKyaIQCRLAJqegP280woIOClkTnufpAjiKaeJ1uzl2zQsqcy9yQL2P8pGaCHP3NfbxQ9azxxPzSaCW6fKBmJHTVAle\\\\\\\\\\\\\\\/9F1m0vHREZ5n7END+KdY67PkG\\\\\\\\\\\\\\\/xfzASEbgDssmdGh5aeW97065zzs7STF2585Dgfk+qOcd5cChvUs8GxXYQcMNUyvGNouiTtmhavlRWPom1twF6lbEEv814aIeItTv2QAsNJeaDQdy\\\\\\\\\\\\\\\/kenRK1qOpQPiZfHiD+Ykx+56W9prQzYv5iLdfgJY5MQbGwupZe4zBQRs6GhBu6ktHP7OEnK8yMFn0KwapcmdC4y9Tsyh9zq\\\\\\\\\\\\\\\/8XoOn9GaUCa2GyppeTy\\\\\\\\\\\\\\\/pXR70PYAP234+fDB5vgJvj3eA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022a16jRq\\\\\\\\\\\\\\\/x46Lu2Gd60McpAA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222496d9255f27c6b6c72e4b500cae89ad477f3b594b5b43ed31259e3a22912548\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000112corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000112corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;8\\\/1\\\/e000112corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000112corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000112corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000112corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}