{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022rIR\\\\\\\\\\\\\\\/xl5MlCY5JwtD1\\\\\\\\\\\\\\\/SwUATB7+0khT7Ue88wu+m\\\\\\\\\\\\\\\/FZ86ssXUHP37Mcg82N2wT9msJkr5J4sfndnP2BQsXKChmEZ37U\\\\\\\\\\\\\\\/HtFiGrMYVVcsjFh70q+cUDFK6VcRwdlEVfYTDvZUK5P9WPueOXUWrYqUYERvrqi6OliNXybXWCAPCFRASxvCxOo0+\\\\\\\\\\\\\\\/o1HShUDrKOFp1Sl8Q4+0D\\\\\\\\\\\\\\\/Itw0gd8it4CWvj0Aqxp9U2ZBgkoMl9cvHalDI4zR33tfCz1kB3kjbvcCkqAbm\\\\\\\\\\\\\\\/oz4KXgDooWiFtUvD+CYWez6EVuR0q24fbNgo5GQrsLQINtPmZVHG7WJt6KsGoMpRVYkZmcT6nn2qe7NvZR60ldQQpzN40taaEee7WpTHA\\\\\\\\\\\\\\\/zVxOQITGQjP0a\\\\\\\\\\\\\\\/CkaacUOB+oMpSTDp7ajwI6UV2Nz8jE3zMsbOnYfdHhk4LkZmd7WJiiQPnw5dc14SPtvCuv9XGlgM8sJVcJG23D3BciWM09JkfmKajtWPtddNkPauwegsgDe6YKfnSG69J\\\\\\\\\\\\\\\/lag+TFGGIERZW8YKEsJlHOKdbzyvN+FUOS1lq7y\\\\\\\\\\\\\\\/r3nioJXlSJtdbnZ1vhW6Ge\\\\\\\\\\\\\\\/APs2k8hXbG8j8Hd63hBQDhNfvW8iJcGATCilx+52+aIfcCLrzjFHSXySAm9TPeRdt6Oy3C853kXwnL+\\\\\\\\\\\\\\\/G\\\\\\\\\\\\\\\/iYgSMELS+3XYu2MOpG0dqODb3QPbrGllR65jLPU0sOJBxhGXpfCuV2uHbNTuJ+vB\\\\\\\\\\\\\\\/tbhR3iuM6HXx5B5tSK5dF1iGN6ihfN+MW0QUx2Pl08rgZBYyeEDPQ+gX7QvZTVPUYXUBjs4rOp5wcwUPLQthcKlbEJCPzce0T1PdcTV4YZTY6OedFOEjQlpE6MmQWHGRJj2AHXiAsHgyF2dP7TJBO+J8SzYoGeB5VCgfhdSlzREiLfYesPYI4+2ppVyczC0JS0FBjYsMQP7NTDdYLx2AqjmKRTVAxQLSsz3Nj6nIdaWUC404\\\\\\\\\\\\\\\/Q0t3AXydbpQn2xk7L5pXuzQdHNjygx6cbaH65q8psYEOyqW36eMc8pZSjP10TnIvEKbwBVQ\\\\\\\\\\\\\\\/k2KkK4M+3r6n5cQ1eOS94fmzBsj6UK+O0G8YBaQzg5e8onuW0k5G4eAc0RGrr3i+v46MPmrXuNE+7vG9endkhxHD0RYWhXEA7nD+OJg7IJGUxm7e9y43JtfKlh43jffwC+Odg2i6Al86sM04PQnmdw2gkNGTImvDAyyl5+tv0EGbtpFGkiRYQmM500G2of8M3vZIdRI+kp0vr0jYHaiVosK0H7UEFBZb1rYiBQTKNtqHRDf3zO\\\\\\\\\\\\\\\/40N6f3ifA7bLPqN2yZ4MQBj64cvYBAZSmHRzaamADuSXZ1iF+kBW3LLa3Ltqk4gc1ckt40xB\\\\\\\\\\\\\\\/0j5MYNS\\\\\\\\\\\\\\\/ThinXxVNZ7MLbdM11siGn2P66oRkS7Z4NhiosTz03z8xkGrUW9Ms7nKdJYAGu0oIQhyOc7kJSidRPGUl9EdTxBk65cuahy\\\\\\\\\\\\\\\/FvsLC1+DlMvXyGI0haRx0EULSXkLTbQ9PWPxTgxjQ1dQ\\\\\\\\\\\\\\\/nyWq7zzOBxK0ImMSqNLl\\\\\\\\\\\\\\\/RcWxHqkyFqb+uzQ+J1WHGE8fcyc2vu+Tm7rVV5EW8eg+g7SAJs9fwAxGboY1QOg1T2K2y7pB6eVOFaCifix1dkn6n+XoxsMk8Xpw57ZLcjScGsCFKZSnvfzNeCBkAlhUsfi\\\\\\\\\\\\\\\/5VdGzDw6j3rDsmf3ZpGHWwPRZ9raMIdO85j7NEqDXMcBkbTvDh3AG2sblO9XFct3yFQv\\\\\\\\\\\\\\\/+lnrcKsGcSylK5VDAXcyf3gB8CgzEjXi5j23HHFHsVgtnAKTTDBPDoREXAv\\\\\\\\\\\\\\\/S9l0frjVHN2Uok9TSvHE+ifbr6cSQKMWSwQu8KZCSCCRe6H5VnmkGpTb17VlgdbPXrC4tV1tbhb94legkJvgdN8XE1Yn7MHCmpZ5Di\\\\\\\\\\\\\\\/l\\\\\\\\\\\\\\\/oakbdvg4GNy4\\\\\\\\\\\\\\\/IHb2jwc9Do8QvmAZ2XwyifxIDE3MuMAGl\\\\\\\\\\\\\\\/HXOnKPX2ASE6qCglBxpj14rvLhllAo2V2PrBoDx0qc6I7X9rjduiYUNaErvOS+Bdviu375Pn65HQM+BgNMpPwuw7uMZnvgWKalk1fsHK2BkfRABfd8iIyw3L\\\\\\\\\\\\\\\/RvBnvVuwK48lvAUKBBlIvvoqA4+unUx+49\\\\\\\\\\\\\\\/KXCdGcDZH6d44CElpGYFBNH9m34juIQzwqLd6krDkux46cgD2Lcemiy4wJrWmw+Qa9mEkkN4Rnh7OPGzizRKZbWo+Oipu+6uPmWcZKTMUKR8FEWlJcD8faH8fnTlI592YZchcSAeoFGFIpBU35hQXJTFycFT0aM+nyhQaju\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/MnBI\\\\\\\\\\\\\\\/98QkFzAzR0dawxDwz8lX0EOOxnCfolDYYXUVbVu1nFjAJeNkeA+3RXzeT71ZlYCyRGjXF2xQdRiGqgeU7YYL7NTivvcly0j44HoZum\\\\\\\\\\\\\\\/4TetJq\\\\\\\\\\\\\\\/mmHuH5EDhmzF4DXbm+AQXVWSCCSPmnQXr9TPIAc302WnQzg1sxbijyS5OwzGjykBRuegwiFnYzYOPY35bG9EB6\\\\\\\\\\\\\\\/aG0ZdNAJJS19to+By9suFT6uwdKn180gPZh5vg9ulvCm+jghUVdb5OrwYo1eBt2cjNMMPLBEwvF77HP95aAF2PVV598cZIcRD982phFAUR83YD1XyzkqY6mrZEM1Iyp44aKg3qaZI+aM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022pS5ae4Ct56duN9q5I2ZgOQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002234688a6cfbb72adb491eb2901633af99d51d6510f36346ad2d917f052fad7ddd\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000371.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000371.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000371\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000371\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000371\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}