{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022D68hqIPUQ06Fjc9j1B0d0jLATBGfjsyOq5crUOLgBesC1TCzU\\\\\\\\\\\\\\\/ifV4QW09vouY+z9ODhmqPQs0gwI3Dpt+ak3VwJ4EXMg\\\\\\\\\\\\\\\/7CZEJHxGZBUF2FZb0g5jc+Poapa+fps03ttFYKloRFJUGBCZPEd\\\\\\\\\\\\\\\/YSth79GxXU81oXbz1C1Cz2c4GoKOWfLPsFI7iJM63drzJU78K3jA46rbrPYRyFkJqVgC5cwmYQZa6CWUP+7ctTb24dU3mEZ8ep2NW1XDxtviuezV+ziPn9pGUxCd5eRDTTOZpF41eUZqW+d9Mraeq7MD0SuJcmAzw1OXNhi6sgrAhGszmggmoZM7UlVuA13rNGWmdwqsfnDs9qWSQUpL0V5MhIkDJj6T949oFja0p4d5Io2QAZBzRspSs1o7OtGz70WhwsEoidc8buLpdUKmi0pndZL5mgzkAMNEHGTa08TUDDMuvjewB8RnbhA5srZ6COljktdx9rlGcBYFrXuQ113wyXdOghAzxlfBm6hwfnD66MSl4xqLzMz6PsCWhQA\\\\\\\\\\\\\\\/UB8vJOKOrfBo2s35xmhW2tdfpp8d3Y2f\\\\\\\\\\\\\\\/cmMl\\\\\\\\\\\\\\\/EFTc+lssXQwUnfVkHScgSguqkOi4x3qt0KlsGc8kPwxgoFTchMqTwD99CZuk53hWLO0IgpKvpf3oMtgL3fJ9Rlv9gbUbjsITslVmSDbCQ6a5Ac1\\\\\\\\\\\\\\\/Zv+acS0pzpg53cTdkL4dKADLzZpt1qb3V7EbckX8dTkgsiTmcuRXYbJFqUUdwm9Z64y4pAkUtMXjcY\\\\\\\\\\\\\\\/r7wVg\\\\\\\\\\\\\\\/ckkXr53U3z8BSM5SUo1JTXDKZvWHivmSh7hdVInK5ccxOKlEAL4wHfo1GG4Ymi4fHiBYMcmxoBFspGjAOqOqqYR\\\\\\\\\\\\\\\/mY1jqEeTEp+g7fdZqyO2ZtAlEofbGxvh87a4vVjE74uao5uzcd370V\\\\\\\\\\\\\\\/iPHc5FxXpyyaqblBiaTANjOZvOTyk0\\\\\\\\\\\\\\\/J8jeGUJtKDJ60fRB2huBbQPWhM3URYKy2XvBn4VukNF2MV6EulW3GaC4Zm6o9LqoUwR9uAjqNdascRNqwnI3w47XukLlhOtsmLYqRTP1QP4h0g\\\\\\\\\\\\\\\/Yrv3w5lhSZXcQ4Wj3NrEo+ZBhsYMmoeO+G3e6tkcklQKua40Lw0J\\\\\\\\\\\\\\\/NdlDuok57EvYOlVrs5wbImUNHJbXKRILLqYEs5kI4c4SThrrpGtz2nxQubUKOdCjvTfBiqZV7sOELQOU9X28KGHjUqJ84+ggmAPs5X4\\\\\\\\\\\\\\\/tzI2X+ixCj5qjmJ0EiFq+hGKgTWX4eT7+EmTJqVyEnumAB7aEMCIAmj3fNjYjHj08ykmlkzdT5+0XjckYeOZYvmGBzqetV\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/xu9hMm5AWhwP0zimRoj3i9PXX8vrXeQVPdrjbhSh6iz3Fp+9bmw4baNg\\\\\\\\\\\\\\\/j1DOvIUtRn0MqvmMsuSmIEkA+KN\\\\\\\\\\\\\\\/VufWSuhdkD3TDOvXv4xQr2+FUe2OqQyfx6pkCXQ7pcRWHl7sbNowlnfkqcA0X+W+kVLZqpoMCpVoBvF0yKdcw73RHl022mqz3nEc9Vn+Tr\\\\\\\\\\\\\\\/guSf7R0mhSFzdYWQT9METGAqOhivwQZL8VNk9QDPGA6L4oKroLY\\\\\\\\\\\\\\\/JlB1Ds72hmWOm0nE4nnvbMQJxG1+SmDqEV8pdtAcGNRMHdUMLnvdDQkbPzo4JzwwKMHBZBQDxZ0KkrdYoTpjBjdhtXBL6HRzI4roDzRwuNO0jAgOZpCkDPEvHL7GLpsB75Unt6k6BI6\\\\\\\\\\\\\\\/wAmrRvzxo9S8z2iGdJfbkAsPvFIPZnqmUBO9Mc40Gmr3ZNXTmBb35Sej0p+BrK4M\\\\\\\\\\\\\\\/MvLiN2lLAvDOGYFKj+Aq6s9\\\\\\\\\\\\\\\/Tct9sdiiuROIMe0DqGhSKzdTt8v8Nmbodiw62t2jPByx5elz9sOMkzrvrdW0NwaNJRIkXi4mblzzxdykdm\\\\\\\\\\\\\\\/zc5TXQpVju64XEWZtqt\\\\\\\\\\\\\\\/41zZiszSZh5Q58osW2PE2IU\\\\\\\\\\\\\\\/H4Q+oKZxVlmDM0i2uQD\\\\\\\\\\\\\\\/xau5+qVknuYdqPUsqTDbgYYZ5RZ9APWGja7bFrIOz+3546mNf+IwYi\\\\\\\\\\\\\\\/Q81P6\\\\\\\\\\\\\\\/APvB2xpHTbjerd2kLAnFsGh7bFRuLprfOGpD6nSOsWlocV\\\\\\\\\\\\\\\/CM3zMivVOWWDAFefGYPNY6nbtOCa06GaxMDL2g8ROe4UOWm60oEOD95FHLZHTDthXA7Wwtj17HrtGeLcu41i4joX3ijXSB5DDw+sasBo31pjy5wcnT1YDfBetBVU6e1r6S0E9+jbSpnFgV\\\\\\\\\\\\\\\/48gBdAQNQtoSK\\\\\\\\\\\\\\\/YfMzVKSFEs1Ok8LE\\\\\\\\\\\\\\\/lj8jVFGfm7OX3aYOELAHRl2tall5eRSoWtT0\\\\\\\\\\\\\\\/gxixYRn4g4Aieo7WzVZs7lC\\\\\\\\\\\\\\\/9suyEaNpqEsB5WOzp7TXz9UkTgeR+06\\\\\\\\\\\\\\\/W+pCzUnb0QTQVOH2la7+IXoybp3VU93cepwZoGmaffAfu9PrWiHmta4O6ddNBhsJFi7M\\\\\\\\\\\\\\\/7pCuVFqu7MF37Lrx5pmQif5N40nQ9ufboMMIS7EFSd82ta6tRCryGqA3pIZxRFxin3MuvN\\\\\\\\\\\\\\\/sWShCOxIiHWhL9EgCS2c0\\\\\\\\\\\\\\\/xAJxgjABaKvm2SwCS9Y0YCX9q7iWKBw\\\\\\\\\\\\\\\/sl03UqByX8P0DYAbBwiCD6OQsSdLveeKwCKCuGt2YJhzMniNTjNfEfSzmkte8UHnKzMUrA0Ol3FYw9fyOdkuGTXjyc3oXEI0CncF4pz0uJvPlbU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022y7Qb4CMIx9pYgjBMu9jcBA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bfa9a6f8b1706bc97d8400c40707ed9e0343dc88bb209438a3e308a7879ee44a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000337.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000337.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000337\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000337\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000337\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}