{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022tckoQbUyZHeyrsDY5KX80Sn7c8hClhY01CMS0KqBo6QuNoPLrcPBSB2nuzWxq9NUemGOdDIjVispfCXvI\\\\\\\\\\\\\\\/irUzWp4\\\\\\\\\\\\\\\/zSipD8tMDo6uv9qpssHzgBr4KxDrDpaAzsKfHfIG8hebF3oaA4WtemJUPYiVuJTytKb1jJTUgolonbZjQnPrYSlcMawNxs6v1v8ERKdo+xcS\\\\\\\\\\\\\\\/Bfof38Q8rNfLVyXpaDwbN9nexuGb5PkB4JUIvopAt5CKZ79Xp0ot8NNECcXvYtzJS9z4+eMAf1iiRfj6\\\\\\\\\\\\\\\/8KXWRsddYo6MHrmIQ4\\\\\\\\\\\\\\\/Qu\\\\\\\\\\\\\\\/MpR8r+QgtrFl7C5uL3Ky2ZBsYCHTDxqpnQ8t7ZgyiJyv6NEkR9k\\\\\\\\\\\\\\\/WeFo6B89xpW0+924SM85F7IIxdFJGN1Ah81zett69Mz56l+TdA2S0TSOC1dl\\\\\\\\\\\\\\\/4RMThMch795BIWi9vx+fuwZbvIh3z1r7Fc2EgKkJ3hQ5CNAIiz4G9h67w78L\\\\\\\\\\\\\\\/8JKqpIr5uSzsjvbo135vy7rQQXFs8bfGXKZl5lpHsVFDyKfX5CYlLOSiecTgEFk+aES2NX7zFSZ9CGLZC1FcJTDdDw+uBXyTkXrcjLOFFhe28vPwysRyNyfGh\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/l5cdMsB2L3MkM6y96AvXDO\\\\\\\\\\\\\\\/CgqpU7knfAISdJrn3OGYgxROAuNSqMGLBaRIyH8xOn1WDEAlFhjMdyjzdj7Vc705qgXCT+\\\\\\\\\\\\\\\/MPVPcC6OfzubZ\\\\\\\\\\\\\\\/Ms6OoxmdZh0CixHjqJazt7acoZ7qjq9uwdj90ME0aBlz613vCpDI9x1y27XXUJVzDrvMbVz5UBM\\\\\\\\\\\\\\\/w\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/+030UG9ERS+yDJVI2jvmD+oKDF0M1A+piDzV94wWOdwPFkk1CWE7nKTgGLQIAkvsx4Mo9h0yMfGhN0bkXorLM9lyO\\\\\\\\\\\\\\\/5+txASSsRLlahQzIQdhZlcI+NIKPjqqRlYcm5JxDcZ8xeGEJ0SeKP0R2GrxmryGvprhHek+P7zpyMFqK3Y1bGyw65OEXrMEQ4Vnt3Hf8g3GygJTllRO6dt7SBlgqnyy0lbADrpqjwtwdmQTui1MEBZCleQMWWjnjHQ3olqNN8tOAc32iaTJerEwfNemFiw84bXqO7HBM+2mGhTvaniyLC+8Cok0WmZEUJKLzUN5ttSDgIq+8IEFEQ7BdwMcPYqkVlhtZ3Ps36zDwisuh942FRy\\\\\\\\\\\\\\\/hS7s78d9Y8D\\\\\\\\\\\\\\\/B70alILQIJXkVkfdTZBdEgZ+d8Jt\\\\\\\\\\\\\\\/n83jEKi\\\\\\\\\\\\\\\/Ipprf0l2zzpvBUXEC\\\\\\\\\\\\\\\/MNEuzJV79\\\\\\\\\\\\\\\/lruDnuM7Zl8SHA5BHoj5mi9NtLNfv66BjAgP10Zotxzgbu8xDMBOTpAJU1mwawZ7ckdls+PHq+ux0EO5ro537HrdFgqdZnBETlgQuj+7r3idroMoHw605378fEvJAUIq6EsGz0YznZghNCA0QMSQeWTY9bUA52VLQcFm3HhcBt6+i3bgCJlIXNsJkW9iXlDVQOSDvvy4Y47YU7lln2P+hfbxvaUzdhz3SRPY2zCO2LIZDh9pw+SDwvUYFeUF5IEgZb8MylLHn8r1B3JiNkmLlQo93VybWXx1v5MWFsgs6O9n4FZJqmxCAipWpS1riDJjJHcV5ikdzibDASXM31a4AA5ewU1IKjUp+LdPapGsdC0wj3RmCfhUoZKgWma6EJbtzx3\\\\\\\\\\\\\\\/MXw0sX9QR\\\\\\\\\\\\\\\/+Em1pSQfAC8Svic3cv0\\\\\\\\\\\\\\\/O5INbUmLyjMz0N72bk7j0Sdr67qdH6dLr8Aon7DVZAQATS+tJk27g6fo+HECVX+NOBjsiIz6VwNgiaP8CgNfe0s9xq\\\\\\\\\\\\\\\/kysYPJXgVs8gAsGGJ2z6WGzFZcgdfjVx62VDS3eJfAGstynoXjlUHh04iwIGuG88MiYAOFru8s6k\\\\\\\\\\\\\\\/lNDRo1WCcld64Va+emMqD4zpffkmMj5eGO56U9MqhbNZoeeaj6Hlo0SumSUBvpRVTaUALa2DiFIogiaKmwhB15eI54LS8VHjnGFpQWvReTOtwxEsdxURwMgODLVFa9LRLP3pWdBHSyorpe8QsY9PxPlwC65XIhE697OBKCWUN70oolkaLGqRkcjIioiucWgmG++MVOf3KoaF42eoGOdKYRVy9F348j2isO1MjdYBWsKyra9NMcM4itgL84W87Fes1+uWb86nvgAxZ5064buhunhhaWL\\\\\\\\\\\\\\\/AiyNzcOEA2TopMDJ7F8w8fdM3uPVY46Lctpnl2Po7zhjd3JjR7CbfAxpApnrviKE7WVDVZey9U03btTvN7tGzND7M4kjiNNt++RGzKrDCdV0cTOPZJJg4htz9i3skQOa53xzeL9GE4SiYXO\\\\\\\\\\\\\\\/3+1z5Z6cAQohFTwmOoTuimUxE\\\\\\\\\\\\\\\/1GPP6FFxo7l+06pzd7tHj0\\\\\\\\\\\\\\\/ABursJqFy+lF1TFyr5oYsJQNkzKBdJvFUgQTJKEgdt9HefdZCIaOTT5OrDLHFJ2FElTieCt1WgFx8FPeUhh63XXRwqDiVhycevQxPdhhCK+bK+URoEIt\\\\\\\\\\\\\\\/U76vxQahp+stmqkv0UewWijtkbITOFOb5N1ToojNhnd8O75HruDv4cV9pPVbmPX\\\\\\\\\\\\\\\/tx5SEGrNzXtOSFpIteDP25UzYz+KZwO4O05jdKl2qXzjlPym3k9JfRmkocDM0Uwp2t2V7KSp1FRvbvXBteBsKdTnN6SCZeJcz5n9xuBkOavFeMnT30X2Zz0N6SOZrRg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022gJpNOPSnY5i8x5\\\\\\\\\\\\\\\/fpJZF9A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223a56a909dd93512aae12b84de76d428de1b34589a730d14605254a679d315a44\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000587.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000587.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-000587\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-000587\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-000587\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}