{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022jCASJwJ86EnqxrUPkpX7BSvXpt+TnFzD8yCxYxCTObmpHssaZw23qAuOOVuKEs5jnDeYiMstNCJ7gQ39ZsNbV9g8e1inDJET21Kv5IbffMVHQ8wVtN5lBx1yiyfOro3eFoeNUhJ3Dae6xyBQPyrgZCQqJ5\\\\\\\\\\\\\\\/GTfNT1rQR2QBE14bxR2xwsQgLCI5FifiMj3fnYJRRF\\\\\\\\\\\\\\\/I6jRgT2lLqXP7+yqam4vf1qT8q9V43RhaLmPfx52lipaaVh3kILdpWxxA+PXU6cXyxzAqSAxVB7IGczG12ZYVc0GW0WagzlBC2Jg\\\\\\\\\\\\\\\/Z17k\\\\\\\\\\\\\\\/6BkeHXx9Wj39ew9ATiiPdsRtEmRuCLDv7rrYBnDZRi7WfV4xdCFrDOq6Oc54EZXO9jYoFtkFWMZWWgvDPb6EAjVw9A8lXwLHAFl+Ysa\\\\\\\\\\\\\\\/JROwUYPhJdX2OTB85IFtBCRtunw5hftUKd2vEkMGsdibDR7oL7fkPtWmrzojrFxDQ1IKor0OX1bwdmC8Jd2EBkluieXMmWvpF7ayV4twIj6aKGxsSjg+AmXdlo1swqsNdnNh07pV\\\\\\\\\\\\\\\/2b46juZK8HuvGuf9UJywrGHB9ZfsVvWrWG9XABqnepr0ulxb\\\\\\\\\\\\\\\/eMOQePgx1QD9nzkGYSBEzgwWQXcvYSEefB0694H\\\\\\\\\\\\\\\/t8n4u8vy5U5QudJIPG5gNgk74riZtplxSDhvSTn+Vgbf5QcK0U5WRTKdp8X6af1gl\\\\\\\\\\\\\\\/jXOV6mwmhaARSM1SypVdD6MmQUUGk3jcvugoGktI8aByBPqsxizX+uHvVWnIFz6hAesK6T\\\\\\\\\\\\\\\/hUvdL+HnQpPzt2qdAH5SITt2qQLbuyfMDaapOWEe1H7sxkeL8KdRgG\\\\\\\\\\\\\\\/sYTk8Ko8CtzjyQoE9esIfHICae1zA6Ddsb1XTOipYUntggNi8K9yNOz54GXsUetgJhwVcj665ZJuSldRGFiQf\\\\\\\\\\\\\\\/EJRTQDUnkSFs3E+kzod7ADdozMWeAAUHIxinV\\\\\\\\\\\\\\\/WZ53B2U7iKSbPC22MlPIMUWBznzhyLO6DYdySDGxIKLOAgXw5dmZkYfeT6CZudeA\\\\\\\\\\\\\\\/oDTXn7u7N92Ua2h3KBf4SGYNUal4AP9cVEmGYhJO0QwMm+9CVoTzpn1dtcmvnFyAqNxDkhXL46kDvaUYloojQuPDmsmAvTDMZGMQGDrGLIgi+M50khAImE2q8mKLNyOnEeMASa1RJj0hsJBH3i+IlY5xp09p3Gur5x5xWNQmGOtHXON9s8o1JT2bhDB+7w7JbshRvKoBonWt\\\\\\\\\\\\\\\/jQvl3VLnDN3DgdBNhKyxkNkekdvoBPq2ijU4HOApxXDp8nvgtkBDLj+sgGfvZcBbZmrGtupm6AnDjmGGmJWTrXfHUbBJNPQMVWfR8h0YM65qcmDge8LwtyKBovjdPYs99twsk9WgvexDaxLb312D7JawpLSe7NMEQ7zomFcZZn2AT2X4RoDNKd3BoRMo0OZq6nHcFpx1myCn01AuEW0U0gDi2hWeSPyRkzKr1KXVIWW1uApLnK+IhJbWQoAZjGUepiAAciDVjtNvl7Vg3ZV51Z9P\\\\\\\\\\\\\\\/JRLRhOhwgL8nhvF3Lkh4s7edyyaAb5Zc8x2ThWq+9z+4b4NpplqHU79tNG3lIAf\\\\\\\\\\\\\\\/NoRCLkfxYpILzOMVCH6ZKbZsuXVlV4F07lXAhcDQkfkKfzXCD0P\\\\\\\\\\\\\\\/ASNYOZiFtjNj+z26W\\\\\\\\\\\\\\\/psNVUfecWwMZWrZmnhbUJ5+j7cwgRsT6OyeSUAUlgVnFLGTcwR3hfzew7dC1bJOy67Fz2far6iyo8o1O4Bw9I5l0xe0B+c8296OqeMq6A\\\\\\\\\\\\\\\/eGN0U0scItit\\\\\\\\\\\\\\\/AHQMMCoAYxeRTYAlmL1Db3ZWci6IQRGuDR7dJfXaZj5rMAGIVqh2zOJKftE5aGWksSn6BmKMxd0czbLPXxinBMNO6VP3SUG3CGkJU73vxNLSziQoHv94vEE7BxsrUttpzDDFtJs7raKVOPMHDBub9iOMOU8Uk9+o\\\\\\\\\\\\\\\/YCS5prl\\\\\\\\\\\\\\\/LfwWpLTOCEqFv+YfYLA4Jqpo8BiIFwK7St6g+lGDWkq9s13zYgQUVmn4rG1pkccXTx+awKepN\\\\\\\\\\\\\\\/3\\\\\\\\\\\\\\\/LiinSgI9e9xZ5YhjxLhoOFYIVTmREHcVJmxV2rgseOk+99tZi5AZJFO7zSUS+sfIvRnWQauZ4\\\\\\\\\\\\\\\/t29LGUmNus7Yyd79pc8b2rJQOxltqHOJHWpMEKGwS1+zxiwj00S86rIhHg1JlHHLWRVavsKWmWP1+w1ZGW1eQc1qYJYeyg2oOTdnlRb9sg5BQVAHu7UacLUIWdGurbhMVccezOZkOxVnyc3byqYpeIdJ3HLCHfMQaZy6p15otldIjJkwhgEvAyHRtzM9e33bBRwYEMmUlAppqVarHRaO8sUKXLsxR7VfZPFkGpFmwdmDEiK0e5\\\\\\\\\\\\\\\/p9nZivRS5EX0lskJIrY+Ga2cJslEEcCxiKDUJayIBrShX6GVPx5cM0wkFX9D2QV5Q\\\\\\\\\\\\\\\/LezKku6nDLp\\\\\\\\\\\\\\\/mOvZdOjqMcgQpQwLTFU8m7f4FDbr8PIwmT1juEWoVVQKXFuMkllSkyqqXQwogB2QnWsUmYRPR8\\\\\\\\\\\\\\\/hrDIiDjGV10OJEwtiKDNW+Y2kBn0IeatUNdWVXrZVDEl5\\\\\\\\\\\\\\\/tTBRpVzDzpXlCUSDirEIoS2cAQ509+oyXuaAwQ1L8IE5bmaCfU19XYfwkIzGCZVdjFjNEWrs4zuLIvQPi1KZYWuQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022clcbIUESxgVh42sOwjcL5A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222bc4f671891f665a279e4b3da9b700d6f06980d112f53fffffbcdad3c400783e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000144.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000144.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000144\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000144\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000144\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}