{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00228GeLZK3oxQShsR5xs1Lr836Hk1Dm+Qgicprym0UX+5IYhTekVQkNTCr+TkEOEzOWfH21APZZEuAnSUcjb4uZsAZZJSoIIS0AiIaN06BU0l4VKdJX\\\\\\\\\\\\\\\/wJ32Qg\\\\\\\\\\\\\\\/5euoCGxWr4j7d5Tss0eazKn\\\\\\\\\\\\\\\/lmrAWTbPAAJVtaeSL5ycI5B0zhmretMQED+VHOEjAgiovEwKKW2o1yr+5k+IgxQW6wLxe1jGDMAWrEbdSTewRrrdScauuIn6jVhmvBFvaGxIhDwvG1FuyIVx5usA2BBqAJhhmhgWe0JFkIYJw0SD3IO8u6oH7StPm9dKE3GNxmiXbflkU4lJEhO+YZOxn8UyaIY2oG4TXYYcKl8tHFHwEzmEBuGqNN5oobFeIjcOPEJ4pa7Ij8xp641wMXJL0hSBSYcviO4Iw0rQKe2W5UAS9uE62+tmcRcQBjdzcCesugOrFW0MxKWHve+LIxN\\\\\\\\\\\\\\\/0fY7LkZY1tjieyUZyht+EJMBPGrvA3EkAvIsUcbqlSc9qgOnpDVBEInF1omSYhQB\\\\\\\\\\\\\\\/VUx5Koq8qrwWx2MjvKE816Yb\\\\\\\\\\\\\\\/KKg+o9mtxoCFJCnTA3OYBuBRWPSFjXBRbLamsKrImHCHyeEDJXPuxmN5f8GcfXgbxDaqniZSyTTeDe0CFpFuEm4rBT8ddFpIt4tm+dVa7sXOgeIQIwCNHaU9JOd6JFSNQLV+6oCXxAgFW8ap2MQE0Oasf4FZyLwPsxeVn3OtOddFb5yolkIPHShgCbVE6UPgjiMgyN82q0vc3GAWfkovgAfmcSh+Xo7piBuXs8fbKuIsxEIsiw2gKxqI2CuLSqOLzciWagyh0ZKrp7SYIEVeiuo0ccNq\\\\\\\\\\\\\\\/bZe7+EPUr4\\\\\\\\\\\\\\\/d4uYR3YKvR\\\\\\\\\\\\\\\/9H50P836hzpwHzwTTdP0K9PJ0ufrjFnAdGo4wQpJVuLGvOEz0w2UGyWm4BXlza0jDsr9ASKfBnOhUubXL+7pobFmW0s+95paBjPrmFP2hg4ARssh1Xl3cHq5XIDs+WbcK+FwG98hynqne9gNwwU5yvFFe9rn5kJrWAaBIkzPwwqx9+zB1ogEOr9ojGXuL2MxlPkNURq7owhEaYFdTSrkf7hEp3qHiziSdSn+odXZS+YCwjeXW44a50veQq6V9soVlwLCN4YUk8bEuAi\\\\\\\\\\\\\\\/18YHpoRdHFsakonNexWLXUJ7soWFyohcFzYkTRvgmiVauzvWIpVnFFdgfKo4j5rpcHc2uRqAH4JuSTpy2G+0b5PfGP6KL9ZD3873B8Zo\\\\\\\\\\\\\\\/ydDBJJt91sYH\\\\\\\\\\\\\\\/iTTE8zRKcWAYWLJTy\\\\\\\\\\\\\\\/V9Z3KG3fJpDgS\\\\\\\\\\\\\\\/VHUfj2Lp6rgNBtj0XAtAex7Ee2OkB4O64Kp3Uk2FVoXpB3u5siIdCyhHe+mvmVzsvgMH8nWcdcCbrXvz7trNZTixZC76cjzL1OuqQfnCiP1EG1XcC\\\\\\\\\\\\\\\/FQILMDSaKcrfEmRbA1CsZqRICLzKLpSYwGcG8eBBDY5cJkKv3DcQxt\\\\\\\\\\\\\\\/YYslank4ZxTI640MXZIEON9l4A7\\\\\\\\\\\\\\\/PHCxvdrg4dUquVBpmeH4tuTs9w5+cU8yViyrdVfjbvKhHGjxZNdmp+RVleaaQNOgemkva\\\\\\\\\\\\\\\/9in4iHi7Uf06rIv8yvNS3\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/bgMCHVFzPajWPv9TbK00mdDG+awSdYytW8o\\\\\\\\\\\\\\\/9Cam5KR1GB9rzqsltpraTQ4nb30wse9FATU2oR5Rv1wAKzx9MuihMQHcOs9j6\\\\\\\\\\\\\\\/0NLgUTFW77y0XenguxPM0R0jy7Jihe6RsLd5xLxizrkDYvxUszLwAL95FCmSjYn1NmMUI88dhTXSeQmwziO5eY2Ny55H\\\\\\\\\\\\\\\/5\\\\\\\\\\\\\\\/4Jdnv0z0URYmTK9xM\\\\\\\\\\\\\\\/nVek\\\\\\\\\\\\\\\/e\\\\\\\\\\\\\\\/cyQHGxB\\\\\\\\\\\\\\\/48R+HPjblfnB+I7dBiPNoPTqC04PaaI5Yt1CXtDgNrir35Vf3vCkVETkJrwyABGm4cgGudd70sLgzmXZrjdqFbr4Tqmh5mIcRYvUqOqv99iq6YPrJ8f\\\\\\\\\\\\\\\/302KWyr+dlIPiQWVA5+yJyRnehYL5NjsXpO7RW2hhiXVM1YcibRcU45Vo0Kdc2X84wDwCnnHnU3BDoJeMck1mOeDwAa0yLMa4pg7eZTxmliOQQACG0+3dKbBB\\\\\\\\\\\\\\\/QgQebLoVXBn4ylHI1BVunGdwmfLp5sQWyLBxGLlIu1qYfnzLVJiZnOR4HoKQMo3iTeXbh93xlWn7ztb1ehfHQzeEKgmsQKUksd+9hmML03MM0Wki947IyEYlLQmgAGK9+WmY00gVmc5kAD6b6NVEmXr5IM67iKSKtKQlxia9j4MeOqA3Ddjxg3w8Y0vCzsmDcfSFUu4CTCx3\\\\\\\\\\\\\\\/Yf2HcCbq1DyJ4VpyQna0xuL0tlmhykrCekM\\\\\\\\\\\\\\\/fd5V0zlHcIPOQw9to9PVjnBbuWtk4rsfa0t3hSDkLujG92sBuHKHgp0UJZ8cJ+0oyHswMylnQdykbEMFAeOKi3b1WpOG2P4YQV0E40jd8zAvyoo3qEwObhTGtY4q2yexoyIQJKZ1d2W8WkDIkrKA1YEg9Ecg\\\\\\\\\\\\\\\/rCNnOMVKY6fMp6nSFRuP5bghlcIuNyoQIKJEnjn6SBpVTCkHO1C2ILGyGAwZ0gKfDw0KoVpq14cWWoZZ8FSkbUmUGuzjL6Y6tLV\\\\\\\\\\\\\\\/LTKs5LSjbG7\\\\\\\\\\\\\\\/lRL19eGrpURBS1T5ze9udeOvfe2vqXwb3KtcfQENgUiN3805GYhZbBpCnWo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SQqEEaHliJOv04JBWCRn9g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002217ce2e6c72badea7e92e9c7b015a7224ab02fcf46e3e4a3869be21472fdfa82e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000276.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000276.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000276\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000276\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000276\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}