{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022VKCmJANNHm1u78BG\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/sVRW5CE16vFGmaStrxxsdww0LVJH+JK7Pf7luTwhUvcpG1EaUH+ZPLnnONbJfRUFXB1iVhv2ThfnrF0z+z+j2ndtS7YkSoIuCwUdB4vG2Cgacyln+xF8NGxnSthsFvsF2911P7in+O3vnT9z72hdlKbD9jOnnKEj0tiWlmrzUyL4kUXDacaa1qHLLhFIH6nQfQBzABzrdfcoMoyRK0JRz6XTQAUZgf4XR5G7ITva5K\\\\\\\\\\\\\\\/u2w7I4kWEC5obcxpcv4qw00hO9pk6F1kHKy\\\\\\\\\\\\\\\/r0FgVEGOCDCaTRhDm1DI2aWHo0F0kohcd3YwxfWFtXU1WwSptfH5AKTBhXpE2gDUHDhDLeGyhF9WrGDCVR5V9b\\\\\\\\\\\\\\\/6eY8QzceKZMtKN2F4KTjT7b+ufdjRe+aFB1rCNusEdlS10srOIEAuMaCZed3jKZRwtsn5EQrvH2hhANmbvPUrxQkDKeYuw8zKd50qiA7\\\\\\\\\\\\\\\/VYLoyxWORPDbzWoaoq8QSG6Eu1N09uD3qZJuf3AjSGQ8tM2mqqxoREsnJL8dK4kNkTvWWrQDr6IIlryRM2rhgzn4wzwgO251AwGXEkmvWLq95jF+6uJ71TgNW+0VvxTLWXM05zPSpziVfr5AI\\\\\\\\\\\\\\\/izFzCmVkCaWX+PrstbrAP2OcFvJGDbjM\\\\\\\\\\\\\\\/KZWok5LXWiEaKbpft1LhgI8x0gNyWeURAdmeUK3laB\\\\\\\\\\\\\\\/Lp6Cvs\\\\\\\\\\\\\\\/lO3wOTpiKx\\\\\\\\\\\\\\\/slTt7NtCpVcpnRciGXC7wPwySWwR3yHsUlevmuBQ8I9zA4kQHxZL8iE6dKag8xu7NMIQA2A+IS36KeLei6\\\\\\\\\\\\\\\/AUf2toHZ\\\\\\\\\\\\\\\/8F\\\\\\\\\\\\\\\/Bv+WgWRUe60v\\\\\\\\\\\\\\\/HwO612bY+iZ0hJ+5KSlDn4ME7Tkqe7OZgfExoEzeG2CpWg5pswqLSw4kpSHWKZuUjSfgjhKH\\\\\\\\\\\\\\\/HLMeTQOlT1vU21RQGyxdWIfOXjxx9VTWYKlYCwDyJzqK\\\\\\\\\\\\\\\/tBZrnirmi2QT3MGdzoATI0VS\\\\\\\\\\\\\\\/tR6iZEKONrKqSydUnq4ivwJBdZm08R+XzEilGNr84seJz7c2yZA1RE5nUc5NkqGqAeAfhKqqEu3+uQU4RtSSAdilbtfK\\\\\\\\\\\\\\\/nEnH+k9wiqDiBeucbk4mqRO1ZQswgSX39iJOeLe0dC3FbVTrVT\\\\\\\\\\\\\\\/+UO3lBo7GpIeY9D30GuLxwv45lZcxvHBObhGxeYL79N4pLEVtJStkTo\\\\\\\\\\\\\\\/UhN2xM2cK6NOXJdLcXcJAEgguCncmaO69EjtVGGJGjx+jAGeHvEmrUPyQQJyjfrDZoNm0FMjumy7nSGfzcLnvpfj8AaMWvh78+Grdm8HXhiYQqEikVAZFvp3dr2vGvjr4Hj8P9zjLiNqwxOdkqW84scBCDBa5krzBTo9CM1Ugv0gxT7\\\\\\\\\\\\\\\/XH5qkI5hmSZ8vmsH7yi7j1L6cxMK9XLRlHEowZquvlBYNsdzPaavTD1rfTRRgXYS0Lc5EpB2tSqovNbFkAuvD9AtWdMpXlj4NApoGpYbvRwDZcGfXAaxcVlbZPZwYmi8y7qDuw4XWNzCdDnwiKUmz1do4nWX5q9MGumDyYWgO6\\\\\\\\\\\\\\\/xc\\\\\\\\\\\\\\\/3khKvOwG+bMoALVkg\\\\\\\\\\\\\\\/S3rL7KiLcTbcrT81QWnQCtMYzAO+viVy9i+Zk9B5I1fXLRPUQJ8e1JcdPj3iiOu2VyIlkMx39ccv8iliVpsLbiR\\\\\\\\\\\\\\\/7zOC9PObZSkPoGxRP+PEtfn9JHUB\\\\\\\\\\\\\\\/k51yHnn+P7z0NaWiiZa7MPHsiLzA9CuvDs4zTik8P\\\\\\\\\\\\\\\/dttkQ\\\\\\\\\\\\\\\/13uRafAehXdYCm2MtE\\\\\\\\\\\\\\\/2H6UHU7e6Hn4Tl\\\\\\\\\\\\\\\/1dw62UCn4VZspKDYWRhyilg4yvJK3hlM0oNfEh0GXPMTYmyaq6x2dHUoLMLiweFokOgRhRAMkpbDKk8eebF6Qg3IzXLLwI\\\\\\\\\\\\\\\/UI2IWQoVk93PWom3buQfLy7ZdMzqE83\\\\\\\\\\\\\\\/c1AtVFXymjRN+tGEitlJ84pereGJXAmxV8UcTbiOygLfcPaWkCZz+oyDBbOzPpfNW+yUZ3iIIDU0re3h+fsu1tWPzeAjbZiP\\\\\\\\\\\\\\\/BxCRJLQloGu+NZumdEoopMclKYwlJliISzgeVIX9ihqKOL\\\\\\\\\\\\\\\/uXBOKidExR+GNU4hnCE0KoUVb9J23HI7II4iw3pfWYw7c0hbhwaPJnA7C8zPjRFDKFW8ECfKm2jGEObDde76bSr0H9FbBLVARjGvYGDJAgMN8ILCJCTg5uzvsVed2GADCnmlkDx\\\\\\\\\\\\\\\/Lj\\\\\\\\\\\\\\\/S+bTkpVZS2cEctC0mPVlqgKxmTo1kqdCNia3n2Soh2KMF1m+77J6NrPpIto\\\\\\\\\\\\\\\/5XyfWPogcqX\\\\\\\\\\\\\\\/jajxiCDUceTAaHJDCBqaTpgj+HdMza0\\\\\\\\\\\\\\\/t\\\\\\\\\\\\\\\/R8N7kovMJug\\\\\\\\\\\\\\\/vJr87SD7cEvDXqi39WAnZKf\\\\\\\\\\\\\\\/ZfYp2Y5QYT\\\\\\\\\\\\\\\/s4RT2rD36VjR7wCokMx2eZ3ufC8DhnOrGM2xmTsZAXT\\\\\\\\\\\\\\\/KxOsZNgE4Mkd6RxYqudFF6LYl9CpI0uay1icBa7Kzfav+PYnUdvJy9FqvPop8NDqUZpRZ3mdQYY3FPhlDrNbRmvi0Qqu9pEfbgkIdvNmmBytzzavr4DyQlvCV3pYXcWBiiYvaBKsOYUpkwMpofghTaYbAvd7iLp\\\\\\\\\\\\\\\/09r33QIhwnN1hLkRhdDENiYB9oeq+cgI\\\\\\\\\\\\\\\/7AVqobPtsBCZqbFvvOyGRZruZuzcBTgv79fo1aiuwTFB\\\\\\\\\\\\\\\/VHSL\\\\\\\\\\\\\\\/HB2Gy6aypiQgQU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022R+\\\\\\\\\\\\\\\/oHM5vOtPKiksiYrjbCQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002237ae4ede07babe0ef71098bd1c808baed87b42fcbb5a3259a52058a3daf233bb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/8\\\/1\\\/e000400.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/8\\\/1\\\/e000400.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2019-000400\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2019-000400\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2019-000400\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}