{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022xQamBcp4ncJ42Yb8KvdPm59sybFxxu\\\\\\\\\\\\\\\/Yu2z68qjXOFyi+CgsnR95TrEiqWKFr6dSz\\\\\\\\\\\\\\\/sbIta3\\\\\\\\\\\\\\\/RASKGCQeY\\\\\\\\\\\\\\\/c1SYZbcA3ydxcUrbnMqN2nEyDy5O4ufTJ4IMFzIfIQSSKlA89sBz+QgBZ587LKsVKkhpdeGfYsYqJG+E5t8MfprzyNNauMItKfiqzGmDxeyBs59RG\\\\\\\\\\\\\\\/Cytz0YVTPTNyQ8UCkTcPuVRDDwmyrHiDM44Hhdcv6zCSutVbkRXiHvB6JaUqynPQsR2qSfOdvIZOZqNGPwYv3skriV0J2LdJB3m191z8oMN3ONwYFiADPzqVMmIgap+IjF7+dcDxT3Q1hi5Dzp2FiE6ViTLS6RvsQFfbEzp4oOGEMgjY1C6bdoo20GEucaIkJCRg1RM9Vv9\\\\\\\\\\\\\\\/zWJqlnKLB5Ofdz8gqpe0vVGHcj\\\\\\\\\\\\\\\/dclnsKTRABrZe4g2+96vPsoVQQH1yQ4OsPOz0hJ97mPmUeD0f3hHZcdrliS6Mxz1eMU7DDX9lG1KC\\\\\\\\\\\\\\\/2fh58g5Jdr3LmpvIHVBMiWoG0RarVTQnM4sBNKpig7+TnrqtrE9cp8h57T7H+YwNIqspIb9Ozd\\\\\\\\\\\\\\\/++X\\\\\\\\\\\\\\\/LxRVepYFupmXAP3VcFJLer1zDQFzF+k7pcwplq7B5oMtyJqNAEe1cANHiqlS1XH4BtADEmjhFA4NslG6lF97ZArbuLk0ac8sDfqcNFS0NEJq8YB4d2L0317jeBYobm4DawTFED09vsfFZjzVgECSkGMOQyuO\\\\\\\\\\\\\\\/gbzws+5QWYJ\\\\\\\\\\\\\\\/vCEANnXE2mW3Z73nMNF37hNa+UKl9OFGLnUbCkrjo29izknARYdjgvgDiC879L+0Y8rEzUuvqHqwuEC9VcOtaOwtGJAg2fpOqhb54OqcFkrGoI2YkR9PU1jOhgHMmukBuYbtx7a0a\\\\\\\\\\\\\\\/IuI21xm8hNmMkVc37cwIbmu6D8DyaXTqOEPIfxwcIISy0IFtxfX1oJZgGTDjUHuSFPMScDAvtI3jJ6\\\\\\\\\\\\\\\/SO\\\\\\\\\\\\\\\/eoR8EdwHswTTpUckuEsAcsuX67AGY+9TOvxTTUgEJNHmOwZyN+1w2Kdvi+Fy8I192yt30OpVET\\\\\\\\\\\\\\\/SUCem2jRUgaYwxo0EziDjO+cSfn6PxNXuyR7A8r9DWWfvmkUReno\\\\\\\\\\\\\\\/49ofenBXOP9J0yUQEI7F3p5vJu6HHQE\\\\\\\\\\\\\\\/1G3RXzQJon+3LqFVmLPS1tjOqNhtDZIB1XwUXOX60sx+d4z2mfU6g7XIYkHtocmlcxsCLyuKL1t1B28I8RqsXxbfeeYW2iPLsJbDl8lKe8ApWD8kFFphUiZawbNxR3WFIyL9XCXkCusr6ky2d77aH0y2T9kt7U6JrzR\\\\\\\\\\\\\\\/9s4BrP4fDiK8tLdFl8WjQhulazpkNhcaMnLr\\\\\\\\\\\\\\\/HkxrKS\\\\\\\\\\\\\\\/UZvjU3vnoLTWqugEFgTn8crePbYrfqI+3nnNv98JGuwhDHERZCDt\\\\\\\\\\\\\\\/2K1wBRJX5CRtokcwasU+WQkECTPZt\\\\\\\\\\\\\\\/2+AkAUfcq3ubSMiecUmFP0iaNp1moHd7tiV0a3Z2RTudK+9vzdVlS60rapGdJ\\\\\\\\\\\\\\\/f+DdUOBX1NGaRYGL\\\\\\\\\\\\\\\/+byviYEVdMWQYV\\\\\\\\\\\\\\\/kJBQaFePBedBCGIGC5xiDx+5EgOcp7+jnB13nTu8yoKgTT8lrgmdfwtrEvSzf0+OhLsDMy+z2gDRIZtCEQPgEm1u\\\\\\\\\\\\\\\/g1wPKd0\\\\\\\\\\\\\\\/N+IrKz6Kx9wfeoEkJR0qWE13B9uDXqGjE92Wj43O7Jk1DD41eMrLhjOWKJYighu+MhK6djVX\\\\\\\\\\\\\\\/LzehcYW2bwhNoYHPDZk7+r0rFx3eHZsS1hc9iTbTg+1rodIIbjlwCFFxKUDFHqtA5KDCoViwDmpQ1QPueTOlA1ULBBi7gHOca1QIEpAXllz6XCUotBlj7IYJb6l2SYVln6pub2CVyiWjcv1wP2E90icWc7AS\\\\\\\\\\\\\\\/10qW+F0lgxFzZ+x2tRvv2oQiAiHdkDLeazgP3yBUwOnGhwI8wmc8JCMNz\\\\\\\\\\\\\\\/Cm8YvXKxhfbMxKzJ6LMVl4Gc+zFwRb7DwKCckA1RvOBbVxPrfMQeI0lTLruhKxviy7jyamoHuett7SFD6EKu\\\\\\\\\\\\\\\/HWkxVfQo3j\\\\\\\\\\\\\\\/cF1PPo\\\\\\\\\\\\\\\/QjCb\\\\\\\\\\\\\\\/Q5omRpCUL71AxZ\\\\\\\\\\\\\\\/1hd2f5bNolgMUGql2nJgvLUr4NdXLkc8y9067Z96ddErGYB1w86oXe7\\\\\\\\\\\\\\\/bzBIXoRxikbch1E66mm3fopjBo\\\\\\\\\\\\\\\/VtrJ9Usz3QW9JUc1IVao3yaioV14OOV9OUWJNC8dBORMYyGBbyqUyXpD9+JvfCQvfIzi1spPOan69mSnaw91T939SjY8B5ooiAQEdiPXUzTywwh9IrKYMSFAD7xAHz2nNWH6Mor6P5+qsebOVGv56hrxpWPxqjBBZKsVpjcgsNnALgL5qfNMd82rp13t3npZP9NSanKjPRRmTCHCuHpFXhY+AmgS5njrO7BghXPpdOc5\\\\\\\\\\\\\\\/DrfiKkjBgHioBpUaiexEYxQbquy71K6gOT8OfhZI3kLNz9YzMDSAo9vq4Fsp8kLWzsqztrFASyoT7viPIbxASbufRb7\\\\\\\\\\\\\\\/yEoRVi5CHSGTyILrh0PkvrTyQtj7GT2glY3aHa1hTqp8j0mtBZXw8scDf1rDanHWLq9NPyw0fuWqCkaswBOUiTcRvUF2TutxmnEiRI06IctXiwsW5yIA+z7pcOoyFJbSpGeRecIFHMv3278beRZLVyU70yvtbBDPLeNg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Fi63W2m3qwgxJq8AOqb9qA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b65a6425dd5250aa5d8ce911484fd030582d45ad54f1c5c49aa3e3d75c23beb5\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/341.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/341.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0779-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0779-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0779-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}