{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229AQH1SJjsKV5FVx1v8me1K+LDDfkRUq3wAF+QP0wIWG933wq5jyhLoM+WDphEz4XlAmcw4I2I+4jmziwGaCGb4kWLsJqvxoiomxaXOiO5r5UUJydeyCF8cwk+9jo739+pSq1IOwZw7b40hFH7F3P8oKLaZV\\\\\\\\\\\\\\\/itLARDScwaacu+v6+yWoh2\\\\\\\\\\\\\\\/XSZ6fkabP4o6wZ+2Pzcz841weWMcYc35kZb8Spr\\\\\\\\\\\\\\\/oRn49gi9TTT19+Jolm\\\\\\\\\\\\\\\/xPSAifRaBcVQoXM+frczFGRSW4XwAThbDSEd0VodD1ed3oEswzhVUou\\\\\\\\\\\\\\\/tHDIvzhcQ072E9K4cYrX1O51Qty9ixalC4v8WlxZfdBERPB7WtqUgM7fEDCc+zhm40eyo7jTJgGBeUuN\\\\\\\\\\\\\\\/4AyPlgpcWiwdwSFzhiLvoTAcn4az6R9jZcCGr95cxAMiMgFDJPcncNXrZBlAiq41XU7lTtJHYIOwB2jAPCLrK\\\\\\\\\\\\\\\/KlM\\\\\\\\\\\\\\\/gGCteMZ8oTASjKjppxne\\\\\\\\\\\\\\\/TrMWZJN7JHEblCqIDG5A5OglKXWTU3LxyyeBl1kIquWdOZ6h2UGpmyYgqrPh4nCywFuoqtxwlJOgYHbcA\\\\\\\\\\\\\\\/QRX9wmx1A58Bd3NR2ZUvn7eczZ345JwITbK9EgvnxArnTH0dWS+9BGyrp1BGm+S985eGx3Idahp9g2ComC0Dsf2H2FhsT9SA3qRrHMHwiLUrF+CRCl1HtC87gDWSB+VlUNf4c16tpcI1dSEqf81xaXiJ1\\\\\\\\\\\\\\\/u1iM7Hb5\\\\\\\\\\\\\\\/TRxW4rmzN17lVhj8gVCoLWyPD+CDw2Y3VNBYekVOTN7\\\\\\\\\\\\\\\/snCatsqVAwFVxaxk8l8vRK8p+oYIcZW3Mpgxkh20RolZkSBRLz\\\\\\\\\\\\\\\/sPiH18fXiXn4YxI4buXg1ZQJF7cIQWgCeFDitJ5aF3UOZzva17P11ghYkDhhA5NajN9V4uPVRMZKJBobD4yJuYz0JTnAuMR8NbMuBnD1YRUzbNJR1GGB72i+X2p8onmPLfmyf3rCEfYEwWilU59JyTSA0Maw10jl5d1uzl8b3sE20VS4cL\\\\\\\\\\\\\\\/a45CEo4tqkpGtfHNIeTgKcXeb2PQcPoUdz8R+3hkPoP3urnL5jyRIgquFYCkNtNhJIbAJNNGn3FSYdtMHdIYvrSEvJAKimJPv7UT\\\\\\\\\\\\\\\/iON5i0f264NJNGfef300CeZ9jxZQ8BitFEnLpla5kWRG+dLfU692i+uE5lk4vX9ZL6S0Bqd+aS5SRYxskuqnwTKmCdyHAWxMKrCX\\\\\\\\\\\\\\\/Wd3RA\\\\\\\\\\\\\\\/PR4C5U+JMiiOPqCy+nLyc2zmP4YOqvsC8OO7Rtl2hI9f94KGa9TW4pmmy40OBkL2CzYkPCLelIik\\\\\\\\\\\\\\\/qaVJRWDFudZ\\\\\\\\\\\\\\\/0VrPM28ILedEqyOAyQpSuTL4FGqgzjG\\\\\\\\\\\\\\\/mgqvzd7aoQHCcWru9iU5nWePLjLmgyhuRPsEg0i636x0FaXEqDfLMDvpO8uSq7n6BB\\\\\\\\\\\\\\\/qdmX8su0rJDOpXFczHZ1VebBKL863u+js17hz9Ukz\\\\\\\\\\\\\\\/7YTgDTUSkQa9xWfIiB6egsWVOlyZMTvKSldCqByJEA6rELoz9MO8bJ3ItAzt6zyAC+aFYr54IMh9gEDSXuVFDAk5cDz4NXfRulgvplIkCtAA+zO3WOwy33mn9qHaIZbY2p\\\\\\\\\\\\\\\/ZepNvmZiZtKiLY3We1DdJ31W4SK9mGZhrdSnBHh\\\\\\\\\\\\\\\/FWaL7VQ\\\\\\\\\\\\\\\/H\\\\\\\\\\\\\\\/2592shXkRF2BqyNpLTNn6QsDzBo3jsA5Unl8kI3e7L2cVFEiIIY3xGBMI8RutXoD5tq60F803qQAx40RA6vqb0+ebPtGHVAvSCTtNxfskjCfw7hbS46bJUIE50OMoYTXvhXsq1kF8+qWow+9KVr9bus15Mxib2PkuKR86yFiRvshr18OAdUcZYc1jAPMVqIc+XWvVIW631wd+AAsJ38mzm4IsZ92HXAeoN8weTuLh8iovJtLCVeO3iiBar1qvDnCw+CjU8OUOp7FBcRZS4oGuKB7EYqcJ8dLMl8eRZih3ovpT7oDvX72wxritOYcNxFXv1X5TrVkbswtr5cSmxY+tzGsKeVBM8jOQ\\\\\\\\\\\\\\\/pVzWQSVCo9PLXnTKkURhsR3M3K2UujpYW2OUE16i1MMSGI3Hd5ZRC59Yso7WIT1dUz9TW+NHjOXwonBr1FLGTjqWWcsuDeT3\\\\\\\\\\\\\\\/EhLPDvWAcgqqwlpwXn5XDbl2\\\\\\\\\\\\\\\/TcrkLUkLCcxTKEj3OIDGu21UqXzinpe9PJH+nJBBSkbfBjGr4K0uP3SPzR1Op0iK0oe3w7PhoTp1nsZwpTwCzeAsMDOjT2\\\\\\\\\\\\\\\/10ztqo9FSYhJrjs87nCgnQzcYCi0pE8M7MF2s17gcOUdtPJ4gGWicb0S8MGZ9Gef8p+U6xssRrNbb16I4rEwtUAZMkIsy5+65l98FYjxf6iZJ1f4IAy3gs8u4WDQPMPai85YHE+ZY+fyzcrQJqZVgbB7HC+tGiTsTEjk7x7Wk0D6xa13s6YY\\\\\\\\\\\\\\\/Du3UKkS1sVJjxrKBdJh1IHGIkMa02\\\\\\\\\\\\\\\/K8TJP8wYKqb7HvJBIxPjkYwcOQ9ORNFN8pGRBWSf6FybircbzQBXs8If+CHsrUoyBGxJhva0EVUUCPZh5eqCoIlFz\\\\\\\\\\\\\\\/W7UT\\\\\\\\\\\\\\\/XoK9+rzpA28IeC1BxehdvZ0jhAX1aihwjcDhzyJATK\\\\\\\\\\\\\\\/bp9usJNY9GUq9FhNvkSohdimZW0YEYxPl99Et4QV9OWbdkrc+3hoBC2Sy9U=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GuM4EStHzD9gUa+Ko2J5\\\\\\\\\\\\\\\/A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d84d59e3cdace8c16cfb3182c414421f56db30520e0aa91e2a2ca0fb8023ad40\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/341.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/341.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0779-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0779-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0779-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}