{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022dZcVrYnhRxwAWS0qorO\\\\\\\\\\\\\\\/Kb9VMZUA6I9UKzGNNCxml8ppoehezI5sU\\\\\\\\\\\\\\\/iHKVXyxh1XD5Nxm4bTyg2xECPSREFUB7y6k23yHBW7syUgxg9rlNLI7FdboxkJTIAjPFGtmGJoNX4EHvuTAPCJ+KP7e3pEJq+qXnDQRNunVwmBMbWE1lIMFRAXvRCxujnlifQaKYUOW++NLLjaFSaLZh0KhnYLIWKkNBOm5\\\\\\\\\\\\\\\/s1dlgTyruP9V8XA29GmqoydZ1I+v1jXJMObv2OsIB3Z9g3xoVLPRfkJD\\\\\\\\\\\\\\\/Q0oNIr02O1DZEpWIVNVt+g5mRbiDengsnH9hGLe95NJxoQdE5qFDXwMpjMBkSlO4F+yxC5+C2r4dj4rqWEadgF2b6EhzvVu2l2J84KeSt6jeZDB28\\\\\\\\\\\\\\\/K0mYIH4TqZkBMR6+UqwqV5sges3qJ+I9Te3ZmGU6nEOdihWBn9+a2BFh2G7Hkh+R1uIBAFva2r\\\\\\\\\\\\\\\/tBWkORyJqcEjeGUN+8q117Bz1JR7XMfWTKLKPyXS4tRancfpriLmzeVKHVtafWOXXZgbRfIGmKZhE4RW\\\\\\\\\\\\\\\/ZIMcmlFjsx8g38JNTaN478p68prJDIqJniTahSyBfBvcXu0itsQbaaWtAiQnVQORTakKXdmklhbGdrAvqt1jSGlwAbgOba\\\\\\\\\\\\\\\/rql5WClHjCeig5nBMvxiVIpFandHt\\\\\\\\\\\\\\\/cCZAcn5gtb0wUbxi487Evp+hlkEqlbuE39TNzB8KCtfmOOD583CLLdjGWyRH3kECJ5wPv\\\\\\\\\\\\\\\/mVswkXdXchzQ3irvKNpulO0Q+g2TE0sE\\\\\\\\\\\\\\\/gbltycRCnQFBf7liL3mxgVj1++RfBG6CI2VQgas316Ti0p1MLd22jZUsmqQp2zewPSYU6n9LJNtuhhCQQH\\\\\\\\\\\\\\\/hWEvehDuqCh0ax6Zk202BIcVV\\\\\\\\\\\\\\\/AzsQAxgKSNkVgYJpCbbZLlkfxU1859ci\\\\\\\\\\\\\\\/nrmcK3625pee8b0tWhRuNalEqFvaCJ7KxkjsOaPzYuFgc7cuKkRWNiMRICxHLY20UKtCnriW0gFISPeNuhm8a3mU4JQqJw8dxWXH5EhwH8QMmVLUuEhwEiSLCjzojgq\\\\\\\\\\\\\\\/sWn2+A0K6naHAuQiM68FkFyDd4ZZNFbzavGTOwNs7pIQtUdmFPzeUiZkhy2IxYKYC8ZJmn230lslmwRPv0qhrk6kiXa2EANF5IVOLphD2HM4BgQ7TFPxkl9JQStGLcf2HlBHSo9QYr1cJDgT5jf33z2Ggi6INP\\\\\\\\\\\\\\\/r2cTSsZ6j1ylm3yfBy3Dj1wBxf9kCQe0ljrfI0PyCftMCz3P2Accd4RIuGxb63KbQdZeuMYhiFit1H9H3Ol\\\\\\\\\\\\\\\/18OnTTtPyKItrYNDy7Qfu3xDoFE2xwomsKsofzQCLCSZ7zs6EDL1aubczmoI+JSq8ISu\\\\\\\\\\\\\\\/C2qk0JzMbfGq15SBFY+i++JmVk63GFfbHCmGMgUD14bhtYo2l9ADH9JXMRdlo4fYTPDpGKF3I9Vaf7FJqONu3fZfgIN\\\\\\\\\\\\\\\/WVPxM7WHUdJiYAttYfYgy2iqbW4lULy5gfXoJDY+taiJwjI5A7gcGfwbv2xTG4W7Wla4d2XswNvuX5W\\\\\\\\\\\\\\\/r5SXzdgk6SHIlAgMUGihAzGXiOYBdvBjamppNjFQGp5hlBJogC7+r8E2KcpxWxFdsP+gUzXK573IM8GFGlfUSmCt2nQGA\\\\\\\\\\\\\\\/It3fQa59xhvv2tGSE2oqWeZoy+oTrPb9ZKF5JZI4I4r1pPsPLN1xzaVDsEqzlzKxLER0XOgz+jksi++X5uxgl0nrO+hIbF5ttMrE5m\\\\\\\\\\\\\\\/822LYoNy2fKo0moK3vVhOAykC+ZmByyOQgG+94oApSw+YUxU9aE5JRf0kmbygoMj4oI+w44h+OaLoOF1HjMwDblMQOUxJK4eo0BSQy1aWfxofRE1\\\\\\\\\\\\\\\/gJTfZXXukakk0rhuahorRCPiev4Q3Sl+RiFi21QGblt57\\\\\\\\\\\\\\\/P6m0FClMvn\\\\\\\\\\\\\\\/iAjLrcU+jI6EP9sfqC+kDpIGyWYBKYgql+wwFWlve0L+lCAuABdYEUB5LS4BrwTk1rinH+BMQXiPQbIgFKNrBY0VwLKfh6tbydeZu6JC0sb3S0P+8d6a1kW8Y\\\\\\\\\\\\\\\/6f8ecQHPs+c1t2NcNEVs5k1cqmXd\\\\\\\\\\\\\\\/998Oml1BsdJ\\\\\\\\\\\\\\\/Ypm6xSY6lmq6iwOKwO7005lL\\\\\\\\\\\\\\\/1qEE22Ns1tWrEgneB2efzgcAGfxCOhMoO+zpFFW6BYEG+xCCHl6tPql3l3C8WTx8sYEV4wujL9cR++o8LoSQDS4LEMzvhvzKE9Ho7xrmPS12r\\\\\\\\\\\\\\\/Np92eQSHQmMwjVLOMtxPVMNZvRDFpDqY0LSl1hxlqQbMK\\\\\\\\\\\\\\\/YVg1YKFA6BVqUPnXsRcOm2NFchjjpqZeI9wP8uXZFt9Ly8bHsAHkUf20OmrH+jULzZ48u4eYTbZkZqYSDoyAgTSMnjiJr\\\\\\\\\\\\\\\/NqRZkPYzXbgL9Zw85LL1t0DQ5Zs5smr9jlvctx8oIUVZZZ9YyJpp52CdqOgpg9aveSH\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/4lBx5v1IQxylWKoFkDKm4KQmX7\\\\\\\\\\\\\\\/L78EjUAPck0UMyEmINN7R4w1iCGQ0WFBYn4uKHuFGc63b3iyEy+ZMZsSkSSmQDrfTK8A9e9gFK5NmIJ3ENHOa9FnoApRMGJgb131xbJjuZWuPar4WnW\\\\\\\\\\\\\\\/J6EM3k\\\\\\\\\\\\\\\/CvWtZ+2xmOl0k97R2CLrMYXV1IfMmSQgTsPRQdYUIUwFuSX0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022LvqZ5jRpfGiuENwTvaWpgA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002237c776d97e2b3f29a981c48f6f9f427c1c955226d429dc615e58d1b7b877ab34\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/355.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/355.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0777-8\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0777-8\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0777-8\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}