{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022EFimC7v5LhkmZTnhlc7CH0y8c+h0bTMUopjc2Cf7BQGZ3BhaGUNzyhVHTZ9dusepIzAMnoy2s2Xm562cVEPniG1OAV4BL6Wk5jfk8qciSqN97dpVEApKZRzWr+Gb3qVPjNfYRAjjef8tf591aEke7SnLs\\\\\\\\\\\\\\\/CEzuNUzIK6ftpAJBfB\\\\\\\\\\\\\\\/HPX9LFE6W0McrIzVAMQISM9grocJYSrcGhuFvY62hlrGeR\\\\\\\\\\\\\\\/HYSLkk5nBID9wSdHFz7dz7v9JjiL+Mi969yPwIDBusxNeS2HUy9kq4fdnCIbfANf270ZJUb5T420gEH3WU7ZWNdBe8Nv2gNqSPtt4ut6fpNTU\\\\\\\\\\\\\\\/noRKgJCU9CPZWOSa8ScFDEDOKz7ynhFjE+OC0K7hgOL8SUUTVododB9tsBaOv+OTTdduN+58D3RlXCtIGYgUMyPP5hXNjPfsAIGqMFeJIdaTkyp5heKOnQP9M9Fz+5FFoaigGAbrIa\\\\\\\\\\\\\\\/t89X4H63WotmQfErvYZyBV6vc3OAA8OgNqiErEwFv6VonN3gOhPQXjr\\\\\\\\\\\\\\\/fedruy+QS+Q1uEFqAjIDuWp1EHFiwNa3Mg\\\\\\\\\\\\\\\/uNcjEiwxqQWhQ3vtaDtC0zEylAJJ7kfYlnXGF3r0HAb+\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/qf0qM3OpguspSZH0qnTH74uedlV5UVhxziWp1f88mrlls8tv8+AuvBxIQoZEg+IZB\\\\\\\\\\\\\\\/CzKBPGuIac+JZtEV5QgXWUpLHAs2BCJSwfKk95sS7jyVu\\\\\\\\\\\\\\\/lu193k7sXX65get9h7oECzfyC0FXw6rpGEbeFkfL0uvDRBhD+0oU26JO09AqTHJHf5SQYQuV9UtKBfSxoB2rSHTuPzYJP3iSKlS5q54YcEsz7YM6DyppN2MsTG6+ygh9d4pDio+6Rqvv+kq9L7ZeXLk4IYN6NsVVRrNHT3qXFspl4aGom\\\\\\\\\\\\\\\/6jrJMi8kkTmWtN8nEBg\\\\\\\\\\\\\\\/MzSyO0OCyc5hf\\\\\\\\\\\\\\\/8mONE+9rKTyGGgxE8ZXmg3NIxg8QuIUsYH2Ht0ACCdsyIAf286G2om8x6EAlm+vbmFbd4jhcPPSHC690ywRke8v2Fux7WLgLvNmyD51hKxwRDyNe\\\\\\\\\\\\\\\/naaYyx3Toz2ZgAO\\\\\\\\\\\\\\\/rQtHbaJBMQ2dRvPEAK4TWJ\\\\\\\\\\\\\\\/VqUibavT7tPs5kc3tUxlA\\\\\\\\\\\\\\\/9UEH5K+LhDbkt3MKxdM0e2X3rhLQIAv3IVDzmeynMl7lkED9aXEaEfTeHxBYw4ODjKRan3HSXucWstrURzm5jwXB\\\\\\\\\\\\\\\/M2FsaogKhG4TJdn17rHbq9rr7IGR5BxQcCm7IqY+mCOKw1gkAhjr1TVL1XFa0Oj+CT77ppjvTlczzU0D0CKfJcXSbr7mrHN4KyAX+7+kNiTxFr5vbXUXxUR1\\\\\\\\\\\\\\\/kHimBTf76aghdeNiM5IAV17SObKbjYzuB18x4Wnc6a238Mf3QskfVPvkFp6NjNpXUkUJ9NUdFyHU2zqXofRfR82k+C7lJc2uRqmzq6k\\\\\\\\\\\\\\\/S0pvVIWjiMLYIdxYkhT4GcpfyB94BeK18G5pqD1qYDGBLa1678qoNm6\\\\\\\\\\\\\\\/fYCFFAF32M0MmM8MyWo2QLpl6xaXW3T4HVpcoGroqcaQna4lWc7VNVmRZmuNBVs193IzJwRE\\\\\\\\\\\\\\\/ShhDjCpw+9O3jy0AMWuuKCclgcbPMK5caYoO3nVyq33PdTeWbdC3q1D1KLmuHtgnjXerWjfE550\\\\\\\\\\\\\\\/4UU3y1wpfH9IlG6d91QOR7vtjb3EmtHhrk5OAPDhh8IELh4dBkVlqev9ZPPub7S7E3YfO37j8f\\\\\\\\\\\\\\\/z+XRN9gkvW\\\\\\\\\\\\\\\/Kd9sj16dQhl2lYH+v13SI+OTpqiNyifMIGpbMwzFlF1IGDaqmzVOqgmONYsFNdfJTMe0D+O7pwyLaK5HrUKOtLszsBoyVFGvJdaMybc\\\\\\\\\\\\\\\/jcxVSvB6dRWztjE7v8j1GVW9hnHOD1XOr9EAHwQYAeL2Z+3KsdLHIGqvokVA98IK3V9uEI1uTo0eLeZ6wajdXvfJGe2H5USnyza6iLmuVOzzUKk8XjffZEqIKONa7CaCik2iSnA6edxhxGuFo7UPifp918uZFPvgQXt4lp4gyvOgD65My6IQpmjRDkOY5NqAuNXVghp91NOu9erJ5mE0w3FS0\\\\\\\\\\\\\\\/npXN7zRh2baNrC2l3qBkaNVWkpdSVyM0qsnL3QmHkip5YFIwhXFGj7XIty4z5aTMTSVcMO16LYRN7q84gHy\\\\\\\\\\\\\\\/6RqVBtjPdE0VqUgiRMYl5QcYUl7jlMxWfHvd4oxpyPaZteqq+zFIy7alq3DCgX8BgOFLqAKKjPv0FXHmFFmAibHGiUzzU2QNT7Qo2A13CYXA7fCPUVVqv9T65DGW5U1jZwNxglg85Dkm9p46hGgdMtLqrGnvXsJQHwsS6Ebdv0WmlEs22BpunhMaciJuaUH7oNDeQZ9laZlmi6sLvaEaztQv3nUGCPAjWEyGtkUp1S\\\\\\\\\\\\\\\/OynOARz4esrMJPHiO3L7GY6sFmQm0aQg\\\\\\\\\\\\\\\/t7FfXwMTYDRYRi7ZbpsN+68JzsSn4ic84ywsGgc2dOOTRpWm0ZdwJbrZ10d1wpsMplNPla+kdsggNHFwC0pS1jg1y2JWvuBw3mxyHeTdr+1XyrqZgt+L4cfGMaQbV7r+1ODrSjawO1kARUgtfA2RtQkvxppA9TAum5imnx+lVR2jmf+BEIzjXgLq37R7EgysRQaYjitNWnSn2RY+LQcpFdYKd\\\\\\\\\\\\\\\/g=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022WMo9SksVa43bkfz4ra6QJA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226db31b188d9cf1055abbed66ccb698df3b0f21dd71f56feeccadab4cfabb1db6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/351.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/351.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0827-2\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0827-2\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0827-2\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}