{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022BoDqI4DB1hfwM5G54dCMuKN\\\\\\\\\\\\\\\/76\\\\\\\\\\\\\\\/RbxQB3+wIFFvzd6eTS63t331tdvPM6IXLYT5lzRyI++WIMnq6XoNnLdhuJoCBDKt7Q\\\\\\\\\\\\\\\/YPoH7+LgeQu71DyxgrwnwRNNzNJ8OPKIS1AsBsBwp6HoQVPjpZgIgDxe9YmhCQlp8yFzZpK9+Ayvb0Muzwm+yv2nssq8djiKeG9XB9+dnXZPHPeeqg0oBzUSRdxbdNwS0iAB2sfJwEDAtx7vw0P3nn+iktiCoAfA+QnfOQlg73KbAbz89mQ+Y4URktmDlE\\\\\\\\\\\\\\\/UA6SQclj91HjPQ06\\\\\\\\\\\\\\\/8YGXHY\\\\\\\\\\\\\\\/pran92Kpm8UmB3uO2leOGxFzgSkhiXJCECQsXFYR0q7zQ0gZ4Ydde6zPAjWSQpm\\\\\\\\\\\\\\\/bp89Yg6pEiboMSdL\\\\\\\\\\\\\\\/DW3MYGFyHgSSDES5WLE2PeulvxZiniMIl8Tn78jzUQIcdd4MEOBgKkG7kGzujDvKCYg80H75eGD+F9FP9+yPChORARm+cHuiLRNdnNegfVOJ9EvAaIjfTh1P0jFbk58\\\\\\\\\\\\\\\/HljjDCq815Ztj1nNtv+Aahs3IMmITAEXc4iyCuaJjxVt0RpYbh8IdNANaunOlRax7xDSJQjl+ldT8Pvml8jEWqqhwIxiozbSLrYXd2Eo1L2Y2rt9UsnQyXtTSX+a7MZe4oQRbuBmry5p7wJjpb72i8epMQVIbzQBPQwHv+xuE6LY6E773Yxn95G19HAc9Jy5ckrLWnTTZMxHxnOqurrOon0FbFHwMg4MEMeMMYCU4+I8\\\\\\\\\\\\\\\/afevnR2iC\\\\\\\\\\\\\\\/6d4CctZv7rr\\\\\\\\\\\\\\\/QAUIwXDYv2eM4FPJ3key12ArzYdAdoTr7IhULt6fgXlBGq1X\\\\\\\\\\\\\\\/chtuIobhYqnlZauWUZUTtPD1qgP6a8UtZBTxWMuzuXIcaANGQS205HOrhaVpSp8\\\\\\\\\\\\\\\/3z29VT86jE3L\\\\\\\\\\\\\\\/ViAGQRyS8Wa0eOsVriZM3i9b6BhG4JAU6q5sc+js17uZ1rYBJg4uGOmrnQetYQTr2O6gC+xWLt2lP2mtJk+ZU3n\\\\\\\\\\\\\\\/yVfw5Qpvc+BR9Umtmk0ELjOVQUtvWjcfptxKWY5oUGsfUOragmbIw4u9LR4Dn5x8J89dfiyT1eaB7zCwE\\\\\\\\\\\\\\\/fa1j3wae+ZCjVcHgbvuwvF2YUXZafqdtNsNA8aDS83H0+BmFOMual6mfuDijJSVJNUTvYv+aI9uWFLklLRlfOzj6GIyHYdqh7a8CkVHuZ\\\\\\\\\\\\\\\/CTD9x7xHgUEeD7jIPWTtUx7J86ttv4GmULZ1IMETmoYc1jOKdsogDA9SttutbN2QEPc6esAUbbsv3jmMIK3K5QS\\\\\\\\\\\\\\\/xKpngjdqbob\\\\\\\\\\\\\\\/D1uCgRCH4Xl476H24zi\\\\\\\\\\\\\\\/g0v0K2Bp3xz3c0zqA\\\\\\\\\\\\\\\/vCWsl5ySunkc3CcTTHNCK5RCIMBP32+mcsxaR0ZTStgLl8eUW9BYh7oGu4a1SESriL99hHkuXNagFLtSIPRe8UWrdNN956QP2r6CEVeTX+WUS9z4Wabk\\\\\\\\\\\\\\\/ptMHH0RB4x\\\\\\\\\\\\\\\/r7SzULPalZQN78pshdxvtL4nysz6K1AqekKbUGwWxh5ibXgYIt3NqJljb4+llTROlxvNAGIg19FzG9cv2JPxFEJyR7yYLb1RWsuRFSC99lUHSBvBD\\\\\\\\\\\\\\\/8jX6pIhsmExe\\\\\\\\\\\\\\\/dVkD6PsVXyYF+waz15ZCE7oJKgK2OevEaH1xkMxgFsEx0myZijJKAEQJpm28iisCkIK\\\\\\\\\\\\\\\/DCVBhfBWzsuJd0Prh8EcDYxtoixbX5CIYW2MA3KbG7lwmsFecB9dSBnz6UG8+F6dwUirLpwnPS5LQQTwwBSLRV3gHcHkF0751MSqGPTO9A0mJub6LEV+AEIUeZF9iFuKMK1iYseeBxWOEiEhSf2K\\\\\\\\\\\\\\\/1GlDlQbX+By+Y8Pe\\\\\\\\\\\\\\\/Kpn0KUfn8PqpGqSOhpruImTM\\\\\\\\\\\\\\\/ZFsmfrVhCld+MOJ4bhxHXj0hjh2OIdMnNe8bgm4t6bBJuKE8Zk5c5vI3c5bryIiAtauzJ7r4XaYUl\\\\\\\\\\\\\\\/FzP0mogwPfEQhp1ZmbD7d4sur1DHG2aQ+SHL4\\\\\\\\\\\\\\\/5kfmifQG9uLv02FYiNwYu0ROfLozD7qjOprDLcfbefcpc8f5r4T5y+GqLUfzCb9CAhKYooHnl47tMYvh7kif3aftZfv30GEG2w9kFW5YzhXI8YKIC0va0shSB9iIJENDAj\\\\\\\\\\\\\\\/QtEPW945ckJQsDmfm8YokCa6ugZljV0P7Qcb0j2XRc8ckDoWjofiEJdcnWPhmWgjM9isVZL6DblG6\\\\\\\\\\\\\\\/sSMTG5GNajVjedxtLN7M2YT9B1Oyfx4wRrW4V+5OExY+VzFnHYbRFLgyTr2wIpEYz4xDyH4iMA8gN7mw4mSZzieFFucSXRp1oKc\\\\\\\\\\\\\\\/bJuD1kIFe2o6ttENlyKTo8G+icRzTWAsHYL8Yy8p5wvuGY+G++iDZLm9vkdKYg7EmffLlvH9PWEmC\\\\\\\\\\\\\\\/1TqcbU61EON4yDLNHnowUIYalUWgZ8yxofCdeHDYD0Lr2ygG\\\\\\\\\\\\\\\/Mx06\\\\\\\\\\\\\\\/Nu5Y8EUJJqvOtqE2KP19XVfjzkuMu+7UVc68ZUn2MWCzo0F84qGxkmdgCgTIoKQDfmV19iDsCdAW5htl1yeAITzGaxKSGXXFByPEN8RJffdene65qHwicpcqc9wzrJYkHoXGu2tWXjuA8yYS0u\\\\\\\\\\\\\\\/te98kuozzWjgKo88b9ZvOg43qG5Exq4ToT7qfGTCJRa4hjfGbh\\\\\\\\\\\\\\\/uC2mF9YVps\\\\\\\\\\\\\\\/DaBofU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022yfhx1ePuLEKLsB77F1HwVQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229e9d3154fd9ee022e6102c62e8dbf0199780915c0efeafc5690edc0bed358a24\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/302.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/302.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0787-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0787-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0787-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}