{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022opbpWEL6RiG\\\\\\\\\\\\\\\/XX\\\\\\\\\\\\\\\/dL4jiYmadq\\\\\\\\\\\\\\\/PntM8H+XC00m0aEpkaA3ZEAnjIUWx\\\\\\\\\\\\\\\/NYIFjVWsff4Gc2BOqfRqHmVqzIXOLM4AlqfG\\\\\\\\\\\\\\\/6KXwbxhtK+8+MKifwKvNbwd4LSQM\\\\\\\\\\\\\\\/icroNCOMFabYYcRPash2CqLDkF7PqjTNxqRr+jWga1MSq3XwzWQz2fiehxiM89V9c94oCxfnJbA+\\\\\\\\\\\\\\\/MC9edYMrrxgaj0YtGzo2D9zexPwZqc2LTLSEUQlf7366JWzBnf6FLnREJx6B3tCaUL2ZKrgInba1L0nvFEQXjexxemiSOiK3AuZwyMctpo46o9SQ94WYVbARjj5WHyWjggbdfcdKbwP7l9W5KJPEC0+KUtpdemp3TLqlORcMl8J74sRTBfPFgilxmOJJrPrX5oQfR0U8vV4bzz02Tpgorq9lUg0JpIVHGNx3qYFDZ1U\\\\\\\\\\\\\\\/Eh309xlh5gZNw5rDA+JCd+yuWkKbN8RdeuUJa1qTvFxY4lYJq7GmCuQb97PzQuDEGfK0SJdznONINrQmj79Bq1i9Q+zgtV2j8tDdjPfCYM3LsOZrVFyBOx315XAW4l1xtoG+TfsoBaz1yCdikS79iTNeXj3rx98oNWwmD4X1szcJj+\\\\\\\\\\\\\\\/4besxeZOeDurrunTI5NC42YTOdulsJInUWYv7cTDVJgcwK5v0ZCWk+BP4pkuIxKhpHVW01CCo8hr7bv3hueUbuMvsGNtsEoA1Vr8\\\\\\\\\\\\\\\/wiPaB+L3EgfTqLxzNfwODQc2S3Oi4j0cDkmPLbZXfnIkeVxHByeHlnAMg2sJxBv\\\\\\\\\\\\\\\/SHEBah01GLOLe7bHw28p1a0o9ZfAz2PpAib6ipmPDchbPh20vpmQFxQfH7oirRomEpjjFhnLolRSWK5SJcGcY7IigY+DuA5jxw5El\\\\\\\\\\\\\\\/kaO3WUGN7WWapd\\\\\\\\\\\\\\\/kAH3RtE43i5NhTrB5+hs1tVsgMmTJEE7H+VPo7XN6HIq1qP9\\\\\\\\\\\\\\\/u34e4NB9ISyQYOaD+OQa4sK2pQVCDnZtz+2isIgJO99N2CkZJw0Yx8bnYkEsYBZGg9gDyj+SFD67fB2VF4kR1p\\\\\\\\\\\\\\\/87ehqxGasi6zg2zlpisGB16sBhmcrTiFj5wUSZ\\\\\\\\\\\\\\\/xysIlz\\\\\\\\\\\\\\\/H52mZrjN7XrPoV9PGmYmUHvU5Md3E0uOy9OfwoT+WUmkSWBPZdzSf3RytCY+iMHuOmgLuq6L2jaBhTk1y5x3IzifiLejz75GtG4lVVamOK2GoKeFMl6iu8ut1Kk2yvYvtWSLY2QjtLJS1U6pZ+EuhO3P3tNP1ufwt+Tdl3JNUAOnjI93aDHfwTAWuSBhyTOkvhnAdTcgdOMi7TgjuUqs2OZYgsY8AN5eOyWgAll41EPhie7Fax38VcZbUmZ\\\\\\\\\\\\\\\/fn+V6EpuCZ2eYBglO+bKK4xRRmr7xR67u94UEHTdumfG+c36IClakpc1nydbq5PmvGBwVgwUOqYagECk4RrWPq4\\\\\\\\\\\\\\\/8mJ66THfBOK6unY3K5OX1KRiyNvpHgBZuxjRpyJR62oO2wYoUjEK0w9+Gpk+CFE25jwjG5y18gdwUnn06wC6Xy4\\\\\\\\\\\\\\\/ecHz+17LHRVck8Uq6cwIweu1p7t0FP6ASTn4uU\\\\\\\\\\\\\\\/tQ0Z5Qpq+xR10uAjNGLmQzJ5WFw0IzjWEeA4IjFWsdf0Cg01PnmX+6IzI31mShFwqzS9TANXWwSeFkUDnT\\\\\\\\\\\\\\\/uLw6y+Kg9znuI\\\\\\\\\\\\\\\/VZicnPHKNqvDiNE3jJODmTgvA03d5lxKrxQ+aNuhXjWgbC6LXFbMQPJ0\\\\\\\\\\\\\\\/zzDfrqblnDNq554ajWtRtCy\\\\\\\\\\\\\\\/RumnfOw2DsNw7VSOcBhwMYrInLD369tSkOa1pE\\\\\\\\\\\\\\\/OAFn+Mn0uk4x2AZJCTfxfWl8dbL3MCVkVcyUrKEkj5TjfhauZqexT\\\\\\\\\\\\\\\/TNwa05gaueaSAxo0I+vMTcj20kUMXfOVufI4PbaeAxEBrJVwAZrOjCvknbmSdnG20uIQKKpIqXh6P0ZCKOqI8V6Rd+Kt9rfBVDzeZhhIE5ayJTaGUXRrC9iUD2tg9yYBX9HD6XnOeDRsR3S1TSmFTf6vCkoYNOa3sYkjfz2liZd1dHKO9ypPVKE\\\\\\\\\\\\\\\/Xwzwueih6isT4BBjgFNaOpBFsX+YEocuDZycgE3CQRPmZ0cqPRjttlDWLTkqyywr819pXoo2jaNQfqjO5ovcR71ZRMP967+TBwxbcQ3AO+bUV9S\\\\\\\\\\\\\\\/zpIQlcxSbROMnMXn4asFzuNaGu6fnv0Ql8+ox1gTCRF6krDXMY\\\\\\\\\\\\\\\/79bd1WsBqrWAjTV7S8YtNUnq5q6Uoj2Ch3Th+7fqMHU2wIMxKG\\\\\\\\\\\\\\\/z1tQPaf31ZNTiuI\\\\\\\\\\\\\\\/nZGjALAHFaNlVSoXdVuG3iaxcsatMmtsPxNDvAJMLUVASy0\\\\\\\\\\\\\\\/eB81\\\\\\\\\\\\\\\/iZFCD5X1d4DNn5+1T9kz6l8cEavsUATLUtUqREpBYh7PVSmAH6Fahdl53usLNt99fzHVOifE\\\\\\\\\\\\\\\/36XEr+2KdcQ9RgxJ+iC6JdXj7SXZxmbOF9k9xEqtmdBExmC3Z+7MQwYl2yRYkKWmJkWII5XiozyQYv7nqDQzHehZi6Lc19eeOGWS5dAK8LhrV0hWFmUiLSsWgdy+DBvBtXRIqjX\\\\\\\\\\\\\\\/l+V69qbjc\\\\\\\\\\\\\\\/LA\\\\\\\\\\\\\\\/mafR4dVDP3SQGkXP8H6Cxcov7esI7TOHDJrN6m3hsu8JXA3Zt5\\\\\\\\\\\\\\\/hE9m0qp7XfxDlhrEnZKBd540UMinRJ2Uss7hCD2u1Sa4QQ3s1jE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022+ixq8bCdQOVVatXropWWCA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d548cb175f4c96fb9c3974368157be8365d6294a952c5486afdf8766b2821859\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/246.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/246.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0725-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0725-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0725-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}