{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022QXh1uTQVTqXiyByIkjTmU9VgPQzxjoexh84ZuPk\\\\\\\\\\\\\\\/ly4uaNBxYr5eEE7rnvb8zHZOl5UwW9kcE3VoUGL1SlAw3MG+S7K2aiiesearMZ5Qfl91+PMlhfIvfxeozSaY4uHSBBzzetPjxaiZ30oC3Db7bsJxw0fp\\\\\\\\\\\\\\\/X7E7FW\\\\\\\\\\\\\\\/SeYnVzr1oN9Jja\\\\\\\\\\\\\\\/m+QjRXQqn6vFxrb3ejKdQdzWLhihZ7zp1JU2\\\\\\\\\\\\\\\/xKPveV1R6hx0oL+uo6x11iXmX2Uup9oUiFJev365oYWwKrGUiqfCqp8Sdg6FkxFQ1TROcIs27C1LbVQk+86hADScc\\\\\\\\\\\\\\\/ki7rkEO+iAwZXrZgxwNyVlQUYUI3YaFDmxGdT8uXi1r5y6FhnJW2aPSrdew0UFQCkBkTtjy93IY8JGKW94+yAKGT\\\\\\\\\\\\\\\/XvJjYeyunA25nUSdQzKdLLp3R0uAXcBPyIQ3Udku1FYrmHqmKU9y4R3D1nUpcaUwfv2Bq6zapRjwaPvoPGhi1gQS03CQcrag1juVknQp+025swMpC4pIptb7+55dWjTPbrToSPuzZBC5B6CDeia4nmQSV\\\\\\\\\\\\\\\/ys7BLa5K+2HQ6w\\\\\\\\\\\\\\\/IGA8i5yJWrHaDmYWEesBTX4B+As1bda+uymLNmBqv41RaR0cBWejIDnHVS1rIPXFIOZkmw7NCyeGHLpRy8dznyMiFuaoGjyykip4SaCkOYt2+vgQ3TXfxzMqBXDv2HmoCCbPB2xUpkSfEqVqAo1WBb4yp7hY8tlyd8q15RnCKHxCdWlB4wxtCgRPTXV1L5yoiDht77X5IaDPMqGFkp\\\\\\\\\\\\\\\/loeJ+18lIxEF+zUVDbML\\\\\\\\\\\\\\\/oPg8wonMeRcDTxlUFNEjqfIsPnRfkgz8P9ZSo9hEy3xWYILvc7xFBh\\\\\\\\\\\\\\\/BuO0Stc2CAGzZXh\\\\\\\\\\\\\\\/qlM8Yh+x\\\\\\\\\\\\\\\/hvNQRA8VjiMARsxWJGJ4KjtoTFCZzobdLfOrqVjk2E1RRltlIveH23dH5Pzfy9APSR3cYsWcHKWG684eeLHetj4ffT+bBUWz4vbHF9\\\\\\\\\\\\\\\/CFNZgYqPsEplqxNTrlQ9bMQop1byPqL\\\\\\\\\\\\\\\/N6AZWCbIJ0e7e0s9zmBScrMVgt\\\\\\\\\\\\\\\/9aV1cFfUYVq\\\\\\\\\\\\\\\/GKCJwQeo+5bQImyd\\\\\\\\\\\\\\\/lSX4BlCmmdmPs+rtXLkw\\\\\\\\\\\\\\\/xsWpx7\\\\\\\\\\\\\\\/5HHDBtHBPusTo+UjL4IhL+w1n+SXKkcuGFnj7IsfmioeW1ci1aJG5\\\\\\\\\\\\\\\/grSKhGGPBN5XvGprOy998BfKovADxtgx3eVlFy3DngSbtl3Q\\\\\\\\\\\\\\\/hfRN2Gavmr261csVs1ScaSTyXokFFpH3Gx4nHaTLKihnJWdwSsZAUF\\\\\\\\\\\\\\\/B9XEvaerugzAG3UWtZ3w6xkDxsJWU0SXjRY3biLJ4ysQvZY01EvsPsZSLFk\\\\\\\\\\\\\\\/UBVIOcd09DX\\\\\\\\\\\\\\\/69giNGTsZBnOnerF6QW7zMOhnTSuNLBM3mS3ky83jy0xtTy2Vb1C0KgaXUb\\\\\\\\\\\\\\\/NpvhBZmf+LCwOMcM3dJrna10JqK3gsaXhfhm0j07Rg64Tqhua3FpYZdEwegGsqlY2WD8beofriFwoUbl25IqGZchoKylR\\\\\\\\\\\\\\\/6a5PXCcp6IOxSxly3zKn2kGO8Bt+awxSF4fkDhlx0sPpx2OY++RmIr4vHm0WmrtgAAws4ybPXoPTSLLG64Gu8es2kgHozGp1wnS\\\\\\\\\\\\\\\/Um+QqvEojsGPuuoQG\\\\\\\\\\\\\\\/I\\\\\\\\\\\\\\\/1UcPabk1NvngF4BMz32JCtkvZu4K6nUCEdaj9aO2UGdeciG9\\\\\\\\\\\\\\\/DACBWl9XfLSa3TFUEtOthnKPEcXk7gvkIAgGnxGIbu478yba5ADbMVN\\\\\\\\\\\\\\\/jnkoj42v0+jkf+gQkJfrIoMKxyLWDNA1xMC+dAsHmnWqP5iEkktnezeDru5qK8t6AhF+BIvs+NbovfvIRpnC++r1em\\\\\\\\\\\\\\\/1HgqsetB6hwuIKp0psUqiwdyK1kIx9yqluBqRWzEyLNG5POT5y\\\\\\\\\\\\\\\/KrwppN2bShZBSykYLedBZzT4ieKujx7E2\\\\\\\\\\\\\\\/39uxADZiPKMBTkAKg04e2BMH91J0moy1oOKMuORrIlk+ST3Gq6D3NvZ+DuQpckGciy6HJegK27KXvftEwqQd4hnx5E8nk7Q7kgDsP1G3sptBzlrHiwveWSWeRb5w6\\\\\\\\\\\\\\\/4sdVcMATBVSEHuSsXZtON5YVgHBMxvr4JRwlj9YdE17Wv+D+kN6n0XNS7HB2RpZL1mu3gFY9IhnYmvccUO2s7V6vja9vPOz1s3DHxHOndUJtX6Z\\\\\\\\\\\\\\\/Y6IZzy8W9uaDJk2iMT+zZC63NoG6pXa5thlwCKUkO1J51kAUn2yy9zUGBKkyDVkBi5n5VDZkHo9YqqH2EgeIr4\\\\\\\\\\\\\\\/Ng2FRDLFo7s7n1Qu1WUGGCXpvWJZ4mwHcrjrG6yrO0iGfE03lVSZUmB1kAEGAbL0\\\\\\\\\\\\\\\/NhGesDyc\\\\\\\\\\\\\\\/X8RkZaK3kA1v3CQWoBUbySk1W8dXS2Nnj96w3TnABieEI7\\\\\\\\\\\\\\\/0mes\\\\\\\\\\\\\\\/5inGcLW4pi2\\\\\\\\\\\\\\\/7TgNcLd4MRUXrKsLrg9ey35bI6dPXCgZc40Kg0C3N1wCMPQXLdzmFie26tqjGJmkOhPLex\\\\\\\\\\\\\\\/EofW8g7vop4ITjpXhcogmSZHjmCpV2HigSGF+RXHuCOLPyiCLOuFwP9bkUamB88TxjI5T2T9axKuk862lNu3i\\\\\\\\\\\\\\\/FmpZuZvIEVRk2DYztU8pqqKwsbezs1tlepdG\\\\\\\\\\\\\\\/+6\\\\\\\\\\\\\\\/QZN1FHzzNEelBdke\\\\\\\\\\\\\\\/wXj0Sen\\\\\\\\\\\\\\\/5xKCXMAGjYbXrRW2667Y6y47v7nYe6l0yYBeYo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SGq4pGsAgVbHeYHaezXYSA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002220292f8a540353bcc729084310388348ae2cfff9e796b9425e0b801724e604d3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/263.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/263.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0761-3\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0761-3\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0761-3\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}