{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00224vunnxm2HutsYNjVRXQBQ2n14muUknhDz33iXLQnWbBb9rSZUFCTU1QCsR0QLSKbJR51CPAzVr5awzh52VCfdmhu3jruXJDweityJ3jPJe9E5Pc5PCiyH902guJf7Cdce3uVvS\\\\\\\\\\\\\\\/pm8QHN9U3Ex2LSAkuWrpx9CL4KRbBOfHTGmnS8Ba0VUSXz8LAExVwAtfH2p6Ec5H21j8pk4WOYZ6+MQyx71Ty7dIc+oThnAlrNSExymvjOLbxgWhK2yZ6WxRJMeDZuC5nSzUH2Y8khfTqDrs1Bqu6OxjbFeSCpftoBFuDLPT1NMYVb7bvlhd6hYsF3NMfOqccwK2lgxtR5ZmhEeACfAnFQKkus9HoF5ViJ4NTxkhZuHYt3h2Tl8J8Y8teL+kQW9\\\\\\\\\\\\\\\/N\\\\\\\\\\\\\\\/pTcFwjv5KVqn+8JpoyunhBO6wIJc4IwmdbBv\\\\\\\\\\\\\\\/MdB78yNN3WNnBU\\\\\\\\\\\\\\\/ZqdhTx7A\\\\\\\\\\\\\\\/iL+X9r2wzPSyRjPe\\\\\\\\\\\\\\\/2bG7EFxDbq0HPZ0ibhlfygjqBzhgJsa5J6Pbjv1QNXh\\\\\\\\\\\\\\\/3gog9+5zRTIgTz7Q0x4vXKtqU01gLPqvrAON7i+fhklS0n8Ec1YmHiqGe2j7NIKpsm1vdN4c92aJCpPdcxgnz6DIo6hLSQDiw\\\\\\\\\\\\\\\/cOptDjEiM+jBL+hPmfpm8b7au7z\\\\\\\\\\\\\\\/EQpBloRpeTF0\\\\\\\\\\\\\\\/PDrrnHA+Ysg6KlhymfNZbtFVlGwvOivU7QYxNl+8ewjD\\\\\\\\\\\\\\\/hHRBezG3YkfyISZHt1G7\\\\\\\\\\\\\\\/t3Ff\\\\\\\\\\\\\\\/Do2j5VEPVBl+ZVtK9NOQGAUv8v6zjoRCTdM+R5p61RbBC2K64PuyUB58RTX1B4rEDGOXcTR+Xu3Hewv5j2k0dzDkKN1Zn4evlekRIAFHhwrRzhf1Kj3pueGJNoBxllFBJOS4QTPmpaztIBZ\\\\\\\\\\\\\\\/q4KIoSTEAUiIH\\\\\\\\\\\\\\\/L9ykFTirdqH1txn2Cr4fmokJX1rQ5BW0yjQh7lXMhoPop4utpC1BhIFgGBYsDzwX4DmbopFHXgXnZ1LLEOOkxUU2URx70+40xyYU\\\\\\\\\\\\\\\/15pL6MDt5exXDOiUO2SfKSCwv6gxKNyKTr1SNqiP5c3eRGcN\\\\\\\\\\\\\\\/2I2peZ66LN9AiTPXXx0TG3a69snCfewiBapLCM8W2aqkdaw+zarPTHJp09wG71QBQ63XbtxLaVcC0FDWiwPwX+lIohtFXFGezNlbvHqUsUee36K\\\\\\\\\\\\\\\/w\\\\\\\\\\\\\\\/2CYEe15Jb07Eu87It6vWycl\\\\\\\\\\\\\\\/8QeuVUBQmHzBGlyMiF6LUpzddbQxUCcACiFywXf94BFISZrz8KynbGy4ft2jXtqCWONvbD0hwuMTfhqWjQwkDpqqeioKJ5631U\\\\\\\\\\\\\\\/4X\\\\\\\\\\\\\\\/9BXpyRqHNWST5u\\\\\\\\\\\\\\\/K6bQIbPoatvTSK4q+90ejhjKB4rPHQy2xkv7sJiE3i4cg8Fit+rUZhv+AMOoMPS2oXFSi+aYk\\\\\\\\\\\\\\\/S6dCW80S0Tfu66+YSG1KNM6bxzUAtthGZMtx20AAWfLZ3VRIqjjJs9tCBKcdc\\\\\\\\\\\\\\\/hBFNCKyg3Kskf1Wp4ZiZL0QFsqG9nvKvWthvhtHYj4bfk4bHivOs+kqebkPBFuClKZ28cYsv8VWmti7eJCDIECI\\\\\\\\\\\\\\\/R658PFbNfFwXnggwjINTHACmyosxKNkECmi2xAwd7O3hgBDHwnp5VE9H1Q5Ko4sBTwqaBtxhq04eA24GtqhffW8eglEZ9hBlVWJM1OtNYpzcVRt6xsjLpk+zx1hkISh94I5gqBZ1bZqAB1g1AnT\\\\\\\\\\\\\\\/Nfvo7ZW4Ow95PUV2nJ\\\\\\\\\\\\\\\/bdScj5w9z+eVhwsH1yhTFaCclJDbfw1ytr+WpbwOsrivhjWNPcnDMK52IKAOCQ9zqPm2sjuXeIxvnLoqUi7nx+oDxNzH5IfVA11QIXXS5plBsam\\\\\\\\\\\\\\\/0aF9W02Kn0hsB4veAaSOfNJvYCSghD294vgkVevVX6ayX91xteWx6LOo7Hbt\\\\\\\\\\\\\\\/1yWGFz0TyoRkFFDk0Ey94BrYP+ipnJ1y5msbECAT4AlEz34FoHUui3iiXCu\\\\\\\\\\\\\\\/I6w0fC1OWxzwEZjc16wAuCeWM7mBm7qAZ4EKcoijUT8Owx5O4\\\\\\\\\\\\\\\/QQTVASVqtXFH10Le\\\\\\\\\\\\\\\/rr8Z35Q57GhrTRK4IfYEz0nvMc+Eh+pLz0f0h8k2xsEJ5KoA5gCAxzN1Q3HZIqVzeYhtjIk7MiORvS2HrZ0TLbfkhkXVH+nr19iUB2HtZgMFkoX\\\\\\\\\\\\\\\/9WTqS\\\\\\\\\\\\\\\/J48HcAsihqoXO4Ei9T+NG9V\\\\\\\\\\\\\\\/w9RhCh7fbTJEEgXwIHvjUjgndD+D3cK4xF6B7b+Cg\\\\\\\\\\\\\\\/ey5xij71bjK8tJc8afD93iYeiN0x1CXqR+wq1HHKzPgYMSQcv\\\\\\\\\\\\\\\/0MNd9DMe1krQWVM1kRVoPOrXgzJJ\\\\\\\\\\\\\\\/LQ\\\\\\\\\\\\\\\/3jNpj9cV+6LK52QQPwNd\\\\\\\\\\\\\\\/AXK6BvUZv7xEPFwii39EQ+TLf22ENE80z+fqum31snc0zmRBeSAzjz4LAI7OdNNv9x4TYxXp\\\\\\\\\\\\\\\/4CchYwXt+zMyqR1TYQYIlBgYIbLuO1IWIreiJG0147Juw620ZQeJAGzQpfVeGXotMP30GvqGGUxxy3E2hwDOEqH5nc6M8TVMzUlCzueghd6xc92k44W8PhslhaiGC+TN\\\\\\\\\\\\\\\/g1dAeTe1jKBXS4FcMe9CtGSA0R7nCaZePHtLOAYnYkznlBcbWTrU4+1bOJGXWfk8njuU2XYkPrduKETSD5cIRiD\\\\\\\\\\\\\\\/q7qRh8UkL6soT2HwOCxAPKdbm+GNApdV\\\\\\\\\\\\\\\/xpXmzD2pXAVZKU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022boEZm+Sz7\\\\\\\\\\\\\\\/flUxV8IELiNA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002231582dcc4ece146acf9a1585e333030c4d967b686053954fd83494299af18871\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/243.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/243.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0721-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0721-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0721-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}