{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LZuTTNUjNt7zNhHkNZH2XNS3XaToLNSwwCTjObfrIVaNxpd\\\\\\\\\\\\\\\/HYoGPPUbjLcaJl0Jy63JgNc\\\\\\\\\\\\\\\/XNe0ON4v754bLpM+y6WeV58vNB903d6QfWIPQXYjkI\\\\\\\\\\\\\\\/Lr8j60lNQ\\\\\\\\\\\\\\\/LHiYua7heKUjFZQhWHzk6F9WIomN9gj+oWbWECM9cDZ+y+C1CYZPHK5YYMAK6h1yiPjR0fESxU9tMtk7y6KYkpP+5CCeEAxL+Fj7Osmc3BnwcOVk+32ys0JN0ZdhMumkuQBWfX2dmB4nU2gfhrIautkuJFgBfdVzLYTse2Xj1oxnjf4skIe0p1dL4OTQGAOiPDnx00k64Lb3G+i1ucNVWx0YvPDEkvFZ0Z0oBc1aqRrTmRva5zDkEe1eCFhOtBmoqRILie4krfv8Zlw2kuxasGQlkD6u6k2VHPWjfjlBZZeBSaix95kYEijcCr101MvhjnH8xDOvSd0W3dbTWB8BUfuYtD3iSRMhRXfhRn+g51V3HwQvyH4n38RufkaOcRoPosTVjyGtVfJ8KJg\\\\\\\\\\\\\\\/Y1WEX16FfWkB9++pCFPaTDuUNwyDLoCCoqWk0IYTYPFK2x1KgRYC4e8oaqLSmXw3xyzhpGgnfP+UYs\\\\\\\\\\\\\\\/so1VNFo6zso0BTmsZCYn6QFboNYktYOFVmLVUBrr8IUhi4JRLGKYAZ0MMaynxFFUeFk8dYF0\\\\\\\\\\\\\\\/mtHxEr43TrCLlQVSeTPnl5nKlN0jnU9uxKUuCAUhQNRfj552YUUDRkakoMrM9Kl2ZP59SyQqturNoSY2rqYEJAJzUWdfY3frrqZ6bwfDpMblOcue5e6z5gxueA+Bqu7P2Ezvj5RxzASchZqmFJo\\\\\\\\\\\\\\\/yllUwZ+EZdbXwO\\\\\\\\\\\\\\\/FOFTem56FBVqpzI9PMBQY4K6MpvFxvWsrdKJH\\\\\\\\\\\\\\\/QwN9HMjHVRGZXeWCaKXQIxW3WMlxpH0LqWaFnTgH9jigzzctneBTwRQAKO3GKKzvhtYeWC+6I\\\\\\\\\\\\\\\/okOlQWh6C4j1VLCTRoOSGcJWCJbDYmnUl893eBOPQ+1Ox0hW\\\\\\\\\\\\\\\/JG9pXoLvEiLw6rW58abnsGUFROosEVCNsGq3Y+9aDXO7kKml9mqb4l9AhiarXKWyyPzsdh6igpn9ewl9oy5XiSzzALnMW0YVMy5CwK5CyhqVftyg6cZMmh+ZbupIBcblhqS4aR1FO\\\\\\\\\\\\\\\/RWlq7FgCRKOr9tPQUVDGMqv8o0Zx5ExnKh+KG1HcrcFVLckz0xB4yFI35xWw8to4ky2spTZGUctooL\\\\\\\\\\\\\\\/sme4kx09CRGC8rftleymbkR8ftiP8OvPsHCv+dJShNZnvdmSPgFw4vp9sBOa2tuE8Op1eiVNq0I6NBSZNugmGlte\\\\\\\\\\\\\\\/ViXIs9jjLkiRE\\\\\\\\\\\\\\\/FP7tuo2sc\\\\\\\\\\\\\\\/+Lcgvwj5HgdqaOlcDNLCsivTGFe31tqshr96YQ\\\\\\\\\\\\\\\/811UMnQ7sLPFslrzRn5wBb44jqnw+W\\\\\\\\\\\\\\\/VcYMTvKZ8scYlJk8KaiPKy3375h8VT0eShSK8swKldkb8d9oQu0Rw5D2y0Ll8iy5VawBbbVGb8zv7dOtuuR3RdnOSx5hDoeCWdj1xF9LlXJoqA\\\\\\\\\\\\\\\/Jy\\\\\\\\\\\\\\\/s+HIvVT+A7aOC4x7uOAcpXe7aROjlW0MW7T+0amroXLO4B2vM6fcdi+pLBaaxanQ3qKbs8zkHDKURjajAg+dvS33UZn6EFqmRGUPdRFbFeeBxwwPySfB\\\\\\\\\\\\\\\/8WV56Pk9JDl5oz9wRcreCEAtaeRS33WWwfqAK6XQR1pTQfC9y4CXbe\\\\\\\\\\\\\\\/7bA3pRqYifLm10B23SedtUMqPrXnkiaK8LFZXC6LHYYOvfVM2VR1mhgVlOhJyD5AaZw0RYbc0okQsAeDj2fIiLqAkam4BpH8AqcaeXKHnmNMOHSBg8pjGzLtGBxd9q9bUmYeNwad\\\\\\\\\\\\\\\/m2XsgjvrHaqWR\\\\\\\\\\\\\\\/z37XkRsNP2cLrPhV9\\\\\\\\\\\\\\\/qYVKoRVW2ZjsnTjgBOPPcS1+LMunADQ6asL2\\\\\\\\\\\\\\\/0MA07RIt8zYetJNBYyyh6ybZVElW2lMERLvXiW9jKMcPGGznlEvj0Syel5D1JPzKLM7U8fKDYrUaEGs3w3+bOIwSjDH1iCuDQ\\\\\\\\\\\\\\\/t\\\\\\\\\\\\\\\/Q2Lz3mGXmC7\\\\\\\\\\\\\\\/FqftdhsUw+ApI0mMNBecXAeuH1LJGl76xwjuKvMMMiH5owMG32hGYDcYUrYU4BQzlUPgszprqiPfH6xIrWkOb3bMcGnDnvtMAwIQD56wzikTHkqupG4dr\\\\\\\\\\\\\\\/CdwpwU5WnoRPVEulO2c\\\\\\\\\\\\\\\/FzwnUVW00T9mG80ozPkB7MuEh1xxaqTvtgh5IqxQidDf2zRbpaIR+ClLPvaaxcD27sgaO9uGOUQaq0nbLmiAeOXajKR3x8KtKA4cnkBGJ2gqhk+1d+1+SuicPoJ61FM5JYZzZ+HyDijfpW5meV5Ftg27MhJpa\\\\\\\\\\\\\\\/Ep18STnh2hqCLiF1rpDYbMCCccpNFUA1jrgkZbxenJNgpdZHlyfV\\\\\\\\\\\\\\\/dO19BXQzOF6KQbzQdj254tbkysDr36mODAv3scpyFW1f4VdKr9WB6+9LC+mD96+1fn8JJVdpDUt3daMJpqJ7mtQ9BF842fMRCNpVeyyH8ZXzmeVgz3ETioMlDlFjIQeTBc9\\\\\\\\\\\\\\\/tMT4LmoT7Yrl7HDoRc4Dqj3KqApS4b\\\\\\\\\\\\\\\/36UPmOOJeNFTPGjP83nKbrrDCXLRdorbnS\\\\\\\\\\\\\\\/UdZYKEVDDwBAKgTd\\\\\\\\\\\\\\\/AigaXtaZHzrfrp9KBE85\\\\\\\\\\\\\\\/cAZZgZ6remEuU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022dn7e7oYTUPkVuhkK6\\\\\\\\\\\\\\\/xlEA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002281dc5a5447089a0de3ff4b3ef75485f534380200ee3771954672d22229f28b2a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/334.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/334.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0810-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0810-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0810-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}