{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022dgQKyp4f\\\\\\\\\\\\\\\/n7c3+i3KmzXVIUjR0SJ8xrXRyYOF8i8adsxj17Rnxj28I1ZkN7HuqSvTBe77q+sVQM3w9CAi2r\\\\\\\\\\\\\\\/ijT9YwexWx6GI64mV9BJ2QlYq+WZzifqQ8hpv142I0ACq\\\\\\\\\\\\\\\/5tWeRTEKazt96ene9hZlG\\\\\\\\\\\\\\\/3FQ8q3OLzbr\\\\\\\\\\\\\\\/vUZG\\\\\\\\\\\\\\\/qxOIdH9oN4j5Bt9DI\\\\\\\\\\\\\\\/+viDxNvpG828+QaqyRFYG3YWOcYP156Nhx5mRBAE+PM834iNH0\\\\\\\\\\\\\\\/wjkwqvZq+Ynlhd5GITNJ3DKemnOgnaEeOhu8fb\\\\\\\\\\\\\\\/krsN9aJi6YFvTkU79GAJ\\\\\\\\\\\\\\\/wVDWXfTbIEgJwxtdJYIp4ITcQ6j+5gDMQjJWMH1rIufywvY05oDwg2ePBRW+wr7425Srabljkr3x95ETiMpvTNJiNpCwLtaBlrYuXWH6BTKguKxY7RFMqfHL4fx+neRbRJ4jJ1uLdAQsoJScDAPGAaqINKJy6NGXymRZiJ9PRRrTpnKfB22IqiGvbx4x6\\\\\\\\\\\\\\\/T\\\\\\\\\\\\\\\/AFAK\\\\\\\\\\\\\\\/C48gk8RfSyePZDvFqaiNmmMSGnzKqQg270LX5y6zfnbzmHEPPln5TjhOPqS6iMP2g9RqySyjH6O6UFlfR1TBZzVytA9Y9QSNdgHxPJqyggS9+zFhV8+\\\\\\\\\\\\\\\/jKIz7hGcX9BczESP+k7Gxhh3jY\\\\\\\\\\\\\\\/+CQBGbHp\\\\\\\\\\\\\\\/mnrQzJsuV9anxkwSBKrWvYNy6CcPsQ1f4kEC4Ipp2Q+4zKJYNFurnxS12QXMt6gTWrYPinsrzB4qY+U0Ey8GTMlBsktc6\\\\\\\\\\\\\\\/9+2STSPMwIkjSdiKoZwlKOYhbnNhGVSkcg7sxafmprUcVgDYNm8GkyN\\\\\\\\\\\\\\\/G+ptIqQsF+z6Pk5DxODXePLtRKpD9w8hnzZG1VkDdbXZYwxu\\\\\\\\\\\\\\\/S8S7id9r6l77xGxf9Upog7ccytEp6QskP3jYDEYz2VpiAB1vEkNXPOJTYyNfazK7YkF3yX5u9j44yTsHofXNCr50Oj083\\\\\\\\\\\\\\\/Wmxn88wkmaB+JH6UrAi38MrTLEzouPE9MiOCOYSJrT+fG28x2epNhkuWMh3GnB03Q2nHZqEJG5KYM6IZlCEcNXxs0oqvRN6rW\\\\\\\\\\\\\\\/c5e+dpKHOG6TPP\\\\\\\\\\\\\\\/DlbfwKZGF6JL3LfEdj5JNB1do6yRKuL6sYBlTZ3zC2DBqw9YScAUqi3hD6+JbWdylvpcxZV1JjO\\\\\\\\\\\\\\\/fJjiblAhiOzYNDL3E3RTX01fVJYRrdlkjq7Dlr9mnnff6CvaNa\\\\\\\\\\\\\\\/J6WRr+ntDYmdfGyg5wYcdErWyu2lkEl9XZZQlXcBVzGdImB5qNqxhqGwjunu2wlUI+cjQQfjvs1k4yWyN3mPUX0s2VCrX7kKfdlCYSmbHG2LGAy\\\\\\\\\\\\\\\/XBDNsjmD3cwKSF3v9bNfuHGjuztHYh3Zqprvr7weEpD7IG70eve1T4Dwots2T4nEJbk1l4TrJzphC5Z2eL2SBiaD7CAx681d673lsg1o47ANZssTbczV4RIooYktSSsOc4Qg9FDcfyTu9RvvtkGf10OcushV020dO+TeTV8KHTA\\\\\\\\\\\\\\\/vyxy4OaiD8mmOv0Hh0dq0LkWIv2SF4yr++ViE6Tq8l+6zsPF3X8NrqC0zD0dbX1Z0g\\\\\\\\\\\\\\\/ng\\\\\\\\\\\\\\\/pzwLqFcGJXtIPCxMblsks79H7Aj6LbK2o2RxxBviCv5jJUaiaa93YXxDB1xnLCjkGTzFvLVQh2PHpVA+D832kUUMujycSvJjEVrGFCApWlxtG5BNHs50CMKpx3QtDQO73i\\\\\\\\\\\\\\\/BqV0iT8rxV\\\\\\\\\\\\\\\/YEqQC2QUy4t7l9vHPxmiHROq1YADs+spde3cevGlp7Yvjp4xzG\\\\\\\\\\\\\\\/3kn1lXeaBkZNQ9QW2bOLfeaKdBWO92uElNue2lm4aBfl8IIyEvnjzda2DX5kv31Qe81wBRu9e0QA4AHby2iAPjF0GCD5bwBHaOSXKQP1XKMmskvpeU\\\\\\\\\\\\\\\/3U7DI+XNzsMdpNFRIio2diHQSl77BsnSVhvmzWjH87RKpAbc0r9lGtLAFlWpO3Lmp2ZBn+tOccOZ68iQs1+MU5WGsh\\\\\\\\\\\\\\\/tJ1e3HQLw1jJpvE4VqKFBArQL8tIlu6Ki3eG8FQaFs7+EJqpM7DyVpBmPZqKqnpSEbJYnsUTCoeW8rgSrSBlvOuDzPXA2Lq1253WaBca5Fze9jb6bWWuUsWqmNOQHlhm+WpTsES0Dn8cWNrXmZHSiJuo99OSjv\\\\\\\\\\\\\\\/P3IsrV2Vqlb1diMjOyxSNBC8tLcFoH0GukAJnPIaxAnMXufNSFscEChnAdNcxYHBuqdtl0PeUxawJhch7Q3NsS+6NYonWEQi\\\\\\\\\\\\\\\/haJScWuOpu\\\\\\\\\\\\\\\/HV\\\\\\\\\\\\\\\/xoxndeZyj33KBVZzX16Uh8OvHuC8eK16OdGv1IXmwG+kDudnkRTT2WKRkPzpkwnZJMBQeA7ptLl1Nqq0UbU\\\\\\\\\\\\\\\/6frWCt1du0G5p5SbATDru0LLUkeH6UKUvmdIwC2ReORqzN7hMSUMhWwkoe1STEAInHm5ttXUK\\\\\\\\\\\\\\\/8V4Vi4o0UkYyAizMPPdDK0i9FtUODloG8JUwlXvwXAxmB5SBUNrJQEZvpnw82Q37Te9PDENCRqDsmEnXYOaifSgnafaU0LCGXNEKz5t1WqxuDGH5EZOM3f3PcJML79m4baj2Bu9UP8M97RNhIJE0JMQQP4eyqpW2T2kesLwjVitZSGMAcg0gypi\\\\\\\\\\\\\\\/Af0ETji4PW1\\\\\\\\\\\\\\\/5oqOA+NZ6RJOAyTpLL4RD6geiyRSQCVrWiFoDrNxXJjmYM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022zvJYX3K85FESWffTewccnQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228c29f11433f525947fbde7f0d32581bf77f10ba8784db65f9d484e2affa2bb95\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/334.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/334.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0810-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0810-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0810-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}