{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022E9Jbdu4wYPl5L1+XwkpE157rtzXQPY7KhxQBDx4LLAkU7dhvsE9rnRucBlN6XccKG79YkTjUoIr2EGBBb7cAxbkLPsQagNpym3dO7CUZzQ+QIJ4Z1iuAVcj5RoFFTegMsVS5RFJAl5hgf+Sqn3vtCCPB6LW+IO0907Z21JRLdi8\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/rTPUFkjUbp64YIkSKun1t5UZT9bDNuSVqUs3eAG6diMmjB\\\\\\\\\\\\\\\/W+Uogbqd+luYmFG+iZ38qxxbsnDZX8jWpax83VzvMQN5EJjZh1eq1MuJh4JvM8s4ekeTKdQkBN4ExtwQt7lknuQvWoA5Gq3m+c8Ti9FiwfHjyGFKdz9kWqSiVDOURvVcLTMcSHuH\\\\\\\\\\\\\\\/aRVuy4LrxMUSym38a2RjAxK5yLrvzuvdUQcNTAfjpCgcnNP\\\\\\\\\\\\\\\/vsPJNTg0Z3Esac7d1Q\\\\\\\\\\\\\\\/NYUb+Qs2UqTXnTwwDN1yrj+L18ZVpYZ+J1OAirtepk44HPbkyuC8xnTnGz+pE7owa6zwEQjbiVNM82DryOVBpZilMCvpzvIJCFOt0\\\\\\\\\\\\\\\/xg4q3lxa3E1zMbofeIJMRqe7Cb60dI2IPxya+fm0EyLnjVIkxU\\\\\\\\\\\\\\\/ZB6pLiztpzlsp1MabH+t\\\\\\\\\\\\\\\/a+Ls5AEhcvrbqoPGfMQeFAyxmLDg6hDPiBBYrnF7upkC0JWLRLU6VSyjZCGBCkZ7gI98R3ElIJhDJQAPOExJggMdk7w9Id1parBYdAERFC0oi9WN8wNFmaxhi3T5ICc6JAEU\\\\\\\\\\\\\\\/HAnVE3u\\\\\\\\\\\\\\\/Y\\\\\\\\\\\\\\\/XNCrwiprfBJ041E1XpLpiBgmYqSDUQzjKGOAAPEdK37jzXTFUCxKZK7NbVQQIlHJ0p2p4BzdwwGlq2l05tehT6UasuLRuFvnW7PCReO3uL5uFLSwcZtGnxpP8hjNpFEqhcgsxeZWJqJfq1idm2FXM17lpLkWox7d99v7BRFOK4XzJRTeKWzPfeXRbW1EtC3FE9GlF+4jtYoN9U2kZdmL6r7ID5k7O8VaNdUfPOeg9T6x3Ebvlqfq2k\\\\\\\\\\\\\\\/9hV67lY63KKBdqA88\\\\\\\\\\\\\\\/byg20NGmNM1kL9oyXMM\\\\\\\\\\\\\\\/mDoUM0OwDAyefCWXwjgeTTyxhhe+s1\\\\\\\\\\\\\\\/B\\\\\\\\\\\\\\\/4lHy\\\\\\\\\\\\\\\/XddUUMReWhD2Os1fBfBoNLFUZwFzkOtNxFrEKe2D6QGe6uFwfX2CRh7XEKHSPJeHfu4ozCPCZLe9pnYRCEd6i7QRLsx0uA4ceVL365BKvMeaba1VUkCx4W+VaxfBrhxMa4rLVR2Y\\\\\\\\\\\\\\\/40hIz2U+t0+GuveVCQ88XkYDjQXTdxqQ0GZW09Q0G3994eLvYQyLZRzfcFfGQut87r5KrVQQfSq\\\\\\\\\\\\\\\/L7CC7zOdeqH3Hv\\\\\\\\\\\\\\\/UOz3WHTacT21tJVJeUqQqQgoLMJWcm84rKTUKjko\\\\\\\\\\\\\\\/rw0QVxJh1ESIt\\\\\\\\\\\\\\\/nUkr9VoQrXF8tPqAEmNN0euU+p0Dq6HBBmsAVGxlQPDJhX3Vmd\\\\\\\\\\\\\\\/3xmC+wbH6yoZ+OQ2D3Px6ppmDUfK40M0aiGRowCZRhQUxc5yDIa5WHElUSc0ZQ4TQSAYsZlxI1IPya\\\\\\\\\\\\\\\/8968yWu3uNoQukiykWbAqPMgwIWOhb70nCKF6qK9DWNWH1PyWWk+phAYRzfXJg8lziewk++j4fkXafmgNmnj38XzF4YnO4Xj9EKLWH0oWr5xOsQns2l8w8BMWeqXUa0nc7aIHZuEJJ2uyBAy\\\\\\\\\\\\\\\/5IOnSn34f+O4D08t4h8MhUuJKznOqaB43yOX2cNyZmtMndrUqegGpd1w5ycmaksczQmAbACVhlWbINB8KeoCUOxlQFyJl3UotKBWOCrEdBjMhPVV2OQzm7Tqzr86Em7NgSrqp2QlUamS7t3llIs0V4lX6oWnoetkjS2lImSO3uhFK5UdDSlYs2Ow9kmjINZn0SnACNH2X0EqYOOw8MPbRm+ZvwotwPg1iDXV8\\\\\\\\\\\\\\\/FQno4SbAoGv230xu1s2JIpkWgN+gTY4kkSLqK4SQ\\\\\\\\\\\\\\\/LjqSvd2DtNoSQGn\\\\\\\\\\\\\\\/WJnzHXaecEIpltV7nGokD\\\\\\\\\\\\\\\/sKH79MyIhNwIRfzRWBKeE9aZF6LL6oV3nHRFlwMwSQfBmjEJryTdlZo\\\\\\\\\\\\\\\/ogq3imVsJEHN4048ZUyuyPfzUiuaOLOj\\\\\\\\\\\\\\\/k1h3Lo3yGRPfeAiweuqnvxW+ToDKNmihRkAjv1Oz6qrmUbUj8EfqSpkgbbpa5NQwWXiaEtza8IyQ5FVyr8jk+IjynY1WxnVdMfb16zznSIXfSA3lUcqR5XgAHSuxsPZbZOBfug0u9ruKuMOPDMubBYjYgdT2zFDSFhCZKiygBOFXcmhN49J1K1ZSr6I3uXsbsfin9zwnzK6UCn+m9fywZQFym0HeBIXlte1T9fJcA5q8GwP+ZR5NUZOZHZz8JTwyAqbMfj\\\\\\\\\\\\\\\/A4ZbxvSFEH1gPbxm0WEerfJrSXcwJFi7+dig3T+cofgZ4XFRa3a8MeMyibfTgYtN6bRUN2bY\\\\\\\\\\\\\\\/1N8ucPigCe2VXJha7M+8iZsTZZ0sUnm0V631Mw7ESE7P\\\\\\\\\\\\\\\/KSA5Y+m7PVO1XHzOMAmwnsM5U4P8LPRGvqxA\\\\\\\\\\\\\\\/vsaDQ05GOWClof1c15JrqViz5LwvfzVKS2rzOyToHI8n7xc\\\\\\\\\\\\\\\/32+y28JbBmMSz+RvNqrwS3rJAQeIAb1e9mtTvGJ9qlNVcc6Z6Gsu1LhQ\\\\\\\\\\\\\\\/ngaWgxCm\\\\\\\\\\\\\\\/HCZqXfYV0LHz12JJ9zbIC3L8RaM3FB7dSxSXJ1wAQL26KnrUUx8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Ob4cUwrk\\\\\\\\\\\\\\\/vGENxSEjBSr3w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fb7fe6c794250c8880aa3d4808e7435b425dba115cf935e8bad06e0b0d7b11e6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/328.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/328.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0794-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0794-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0794-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}