{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fowjtMleIPCw0TFAihU366m2uEeAE8hVi94PhxCzZTRHfWBGSeBKxBNq\\\\\\\\\\\\\\\/P+93dpLgf2vhWwNAibb87bsgiTL7KvMIxa1NlxA3am5FrZXx1RFmOqnFPgc4OvaKmEt3dI28WhKWW57Zam+VPwoSfl0uouOTa7jjCYxvP5OzVKzwQQzI6nOO8vLIKdIiPuR9U7358duxwEV6rBw6MrdLg1iJ7JKhjgyd0\\\\\\\\\\\\\\\/lsUAG+AixiophnzcIMVV91q8AmvquE2\\\\\\\\\\\\\\\/fljc+SZYpWNMWmo8MojgT2n7slRKiQstm6jNvyXLrq0ocKd0W3szV3D83D4K5eJ5uKJb0PGj+qdPaZFZh7acRVvaJFHkwy6fBBzgBr35AIY5VInDiSA9g7hrj8lBUcy24YJiZ2cnAAr3qQGURFwe0ByZbimEuWD1r21x1Psw7m7VE7gn5R7Ot0SvP5IWe+2wrNBHcEB\\\\\\\\\\\\\\\/fcQJjM\\\\\\\\\\\\\\\/kH29a7UY5vMtMZoc\\\\\\\\\\\\\\\/L6QVReTkPt30niqwk0kepbzRxX+RzQcwmfQ4i6g+XC0I6zbfifpV5t1lemxzQbdylpOpWgQ2k1j3f4XKcCipyBcy2xGoQY20Rr6Rj+Jata82doFSkkpiyODtAUwj5iVbtV\\\\\\\\\\\\\\\/ZYEVEBVRpMih97k7ZxwSCkw6MEEGsxIRptzq00M2pbwVO7Wr0RpXZe12C8Xnj8BmIk0F69IOLQnTWT4T+QLl420D3O33HBuqFkkK054N2XwG4VsxH0H40PNbMJICFG0l78bsqT+egJERp+MFwDFgu0Xo2FfMN8VfcI\\\\\\\\\\\\\\\/T4aJVy2mSFm6+gfacApK9eEF7x0fth2jM02XH5ZBaBWqg7+aFk8EHgltJbrjPKW4D1+Z+hHz1QPbOOhKv+h4YQILhFK28lYWDJw7rqyq5JFW++GobVu3SjFB\\\\\\\\\\\\\\\/A1Dl6NZu116EwL8UogU6AJwYWvJFnN0ypqSKVEnA\\\\\\\\\\\\\\\/9fqio\\\\\\\\\\\\\\\/n5BTUzgRKXiX8OYKqM3g4VaKOBa7MyR0CKjBN+jL7RBQ+NlB1Cvf8x3wE\\\\\\\\\\\\\\\/cJ4tVSHZZC3bKYUKA0TtQksdu4s6bKOMkCtn3u+fNd2bN0JU3on+LXFV+l3jfuEmIsmK1\\\\\\\\\\\\\\\/QIAI7D1DrglxjLQMkIFSzxFuUM\\\\\\\\\\\\\\\/L4j0+EKxkl8stQv6lReK3AnbIZ5NkbAK1ur\\\\\\\\\\\\\\\/G2qkAyflhfqtb2woLqLo4EAXFeVd5jXAarg\\\\\\\\\\\\\\\/Y2fc1o9pxVAsqhGOkZLQOFXhlYjQAY0OtfTFWUAZhsJaL+qGaaTMZAWY1UWj2QPMHHsN2lWZm\\\\\\\\\\\\\\\/186R8jR9l4A2vgRp+KcWLEaKWzeqVJXa+RRNrMw2kzuarZpRpTeiHUIhGyxjN5BrllCaYaYXt0RTKPlW8U8Cl0Qee6wh7C9MLDWhFzwXZTW9LsLl9Acxo50SCmIn611fWXuE4JS3hT3\\\\\\\\\\\\\\\/IY\\\\\\\\\\\\\\\/e2prATPA+mSJwM\\\\\\\\\\\\\\\/nOyX+XNOMivF18POIf0O5ArzVbGdclBKJyjl7kcnxkdpUkCg\\\\\\\\\\\\\\\/RF8q648kTtNErUTyge4aN1Pesw+2USQakBsol1AfRlJghCBY0AQ+VYQPxy2sTN2nj8+GN3c3Nt56GBNBcR0hIseBjtcLlwdTlZ7gVsLNCpaj75CpvtNQE50z8Q2\\\\\\\\\\\\\\\/45Y8nBMdIxloUYFlLqc5lxp2OuyhorDbraOzEkbQjSdPU+zyBHjUiBDPDgLm5\\\\\\\\\\\\\\\/JzDZ5ybnhymeQwIzGNP\\\\\\\\\\\\\\\/lofqF16PCqqqJQ\\\\\\\\\\\\\\\/huPFiFalCyVLkGroDmPydBPwsNOX6ByHtxWQmBm3hjY4Mf8ui02SggqsSXrmylss85imNFt8A6o0UN9Ten1Tn\\\\\\\\\\\\\\\/Jx9LjrMYsyFMIZZSvB2MLDJGrDvXshGQrKxLwmrPA\\\\\\\\\\\\\\\/vzKMIVuJkf\\\\\\\\\\\\\\\/Pn6BplJK24ymwVpaP3EELycB560sBYEHVNjnPP\\\\\\\\\\\\\\\/y1r9AAvHuoNeHbKAWNIiIVK6KOb4yQM7IEq8yNrOyGwZ8LGFicwH2UBWGGxEVT5KbSxZFhw8DCp6VowHVpB1CYdbU1V8Sa3EDXi30l6YCiCPVXXh6jg+owWIK9L6fckHliWqgeGTMRzN3cPefsxhQhyGjxfuz2Li3X2TVeYcbGJ\\\\\\\\\\\\\\\/R5L7f++ZbJ2P\\\\\\\\\\\\\\\/5YvzPqNqFKTI7\\\\\\\\\\\\\\\/+n8t0jSQDvaeSK88vnuec+4iDvoJ0Hu5jZkOwp+lSDIeRYR6oy69s8jjKazXQMNdSuaXyMkpbxX+3Hn0MaCeovdJ3LQubLLIrCUI5X28vPT9eRd7G2\\\\\\\\\\\\\\\/QGUkAsbmiISqlAd6u4pgMv7czDxYyTPJ6Cn\\\\\\\\\\\\\\\/e8DjEy+jgyQ74xZgRg2FYJfgM9xj1DG8H6LOI2bDOHb4\\\\\\\\\\\\\\\/z\\\\\\\\\\\\\\\/5wSxuO6p+A5OASNXSVEJtKBas2tYavocxWoAn3Ki0FonYyjWngaPVyXqTKiax3\\\\\\\\\\\\\\\/03W57WRD5BXZGai5Wa1WEAWxlOdWDocf8\\\\\\\\\\\\\\\/Vi9KOGuySSrIEHqzTqb5jEwkx6jf2PagivpFN8sxdvoiU+i5uuchADR4ZWRSB0egHkjIsXCRTDdBo7s74\\\\\\\\\\\\\\\/9irr\\\\\\\\\\\\\\\/h3S4nUmWZ+k3VMSbOo4L6wyoBeAdW1ZkmWdE7FdEFRh35v73z5AbS0U6svYE0CZBG02IRvqvKnuZHnpAPX3OZ5z7bFRrw6UvCdgBvmDc93HhMG\\\\\\\\\\\\\\\/5abUxzSmKSWDQG0Q8pdYGifwn5BJZS1zFeNRf\\\\\\\\\\\\\\\/fsLgWf2JaLb2d0EX+SWmmdgkY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022B7hr\\\\\\\\\\\\\\\/1l92z6SAfOwThQhBg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c311fccd26204f98413e0f8b57fc0d45100d2e3385f331669a8707bd06663c3f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/259.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/259.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0739-1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0739-1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0739-1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}