{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022vkzbKneEWQKElamnjxc9lnZFzlQOCxs77FV2dtnF7M4MjY1QlzpfmFMr0N0G0LsggiOzu4oCO++RnLGLKZpH5FKx+arHx5q57gnOZODU957X6xugCsjVZ3v67hmkXuN27hwfNK8uo\\\\\\\\\\\\\\\/eB2QNR83IKJWiQzGgWxEdDqcN9Q3U\\\\\\\\\\\\\\\/8j0\\\\\\\\\\\\\\\/MSbeKm\\\\\\\\\\\\\\\/IqXqbvCSRC37mELADkXRTgd3VGegcl4jIJhjVj3QEddyXUgqB2EbpzZ8940HEf\\\\\\\\\\\\\\\/KkRJATXfDlkrmOsoUdjtsfbxP4Crk54qHEuqsZzSCE3xF5PdhC92PffhRhd4VacEEuV9LznA7aJe6GdVqf\\\\\\\\\\\\\\\/qlwqtSq1YEHZNBpiCaj+byAqSbJcfAf7RwNBVzsMHYpZT2W5LKkj5vgWEzRfPGNmbfiPpOvWKmcJwa4do+DkpOYan+GFJZLbuXDxAExtes3ZsyVd7irqOuejb5itFjY6a0FDBf1nrvOvZvaJk9d2WOgYacMhFFV623\\\\\\\\\\\\\\\/Iqp04ZdecqrMfyO6O4gKUU6KoYSaB2tLN4NQK\\\\\\\\\\\\\\\/U51KsHLxJJw8ZU\\\\\\\\\\\\\\\/CnIlHZjhtCmYpCGsa\\\\\\\\\\\\\\\/mbfAa4b0Fn1YGGhgKOUwHnx1wioE5cU2C\\\\\\\\\\\\\\\/8qluhrXKOU4rckNqbfiWFSVSrYoSPbF3do03foJwiBHQ4lHOcstRdO3iLZ17ZkXlosxNldaBJRaA\\\\\\\\\\\\\\\/erbWDm7qpWJR+1mrsxYFWgyBe8+E1w6hfpXdPbljLF9LkwxZRyjhLF77QlmF9gojBi+Ek6NELotTMnUSPKQR421uFPWoyMHFjKP4s9HASrM6hf4pculOba0IDcYWOjWUDncEDqo0qs2odPH9EGqVnsc9dgfkFK1i3foMVfekTqWt40wxsLNERy7r6CPq2V+Bj5iX3sy2anf3++\\\\\\\\\\\\\\\/ck8UgCSPp8f8iZsBJq\\\\\\\\\\\\\\\/ojcdDzrdhNMo3BBVI432yPszU7vM603QzgdHU+Fe90oc6hJnxIJKiweAe3kRzoQ7IQxXwvmhHbKui\\\\\\\\\\\\\\\/LSWo\\\\\\\\\\\\\\\/GlF3ofc\\\\\\\\\\\\\\\/r0+0FiAxGsngJd+YccbCWG7Zz42Vzc\\\\\\\\\\\\\\\/vIRWmAAxE7fbH6D0qpIjlXHmUceyU27lr0BfyXVJ3+3f0W+pgmuY5EpLHkamnvDaUpTx\\\\\\\\\\\\\\\/iQJgnLhHsjwJx6gI1FjZ0dwAwDxceKk9j3oNeEg8mg+LSKEJs1IH6khHyuml4g3kOFWhno+iH8AZHMOKlvttaz182Ls2SAW9zZj28SkcoTGW5F8AI\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/fkliuS24goCK8ZBr7G37QfQHxfus4ZiipHRfyDMA9V2ceF1EG6Dm\\\\\\\\\\\\\\\/RoGEx4d\\\\\\\\\\\\\\\/HdqL\\\\\\\\\\\\\\\/ROnnKdC+qrnZbLREBx2JRVxhwD7qgEWezCBuYcN5M3Dcddws\\\\\\\\\\\\\\\/jb2WjaQE398tqGXo3SI2cV881d4FuyGrT4KswfAtFSVFLirRtKtBLYH\\\\\\\\\\\\\\\/wNd9q+uMT\\\\\\\\\\\\\\\/DxnUZOeZgPNcYYuZGGM3p2gG+AvT7f\\\\\\\\\\\\\\\/z9mLLBhK7gaFgmRYKagwjW2OPY3sueG4rHN0ZoGxv6\\\\\\\\\\\\\\\/uDD82zI74fq+ED6Ig2XqFNUZ6xrrxvVdrX9rFXfeRZoofYv1EzcZKFOUZAQWpTVHsCgj2JrtBrq4auKHgfrrSkmgH3bt+ePM0Y4FHKcGpT5vSbAXzcwiIQSK2Rxlv81Ibfbn5DksY9VQN5prG6ox27yHD5RlMW8WIANkiBjRLHvmmRVdtAKHYoiRMxsEYEp7Hpd4+Taat6JXH+4UdA+qpIdMRhp0jdYEaTLuaQ3SCIwrNTvZhWW4d+M+fV7sHKnp9zLu1+SyZI9oOdY5FQIRjslAI7sJa3Wj58AE3paTEkKMjDHl8n3TkwunYIgMta5FdaIRyqZndnFBxRtxG5GaPzWHWIxfVBgjiIF40N3LsfGTETBdZRG6JJmf0NHUkxAVdoBKX+n6I0eJ8O+\\\\\\\\\\\\\\\/i1fbOBfOm\\\\\\\\\\\\\\\/SvUhVinZ5kIZqLT2Ipot9KUvTeTIYC2W2aM5sLodOFZrLU3pDiwijfZkqAvILX1M1tPQKtsgdd2eUvdK5RtYp+KCXOnBZTNSy47rxol1\\\\\\\\\\\\\\\/EWqEmmX+NeIbDRm2fvHU+I6oXup6CmnK8hU1fcJij873FHlNwo5R3QirnWiVrDibEDAo1r9W\\\\\\\\\\\\\\\/cu2RIIX1ty9WJRfBbNSz3yOcO+5nQ3JFv4D2Nr2Bf+C9ym2T9YuB5Y3ZZwYmobSOH78lMzIP0FrIJmnZAAlXrPa+byzXUNQsWM7GVI1YFgy+Wftx0xUlz02RWoGqGPMB0hrWWAmcZxmL42X+FtyW1zz9qDhG3uB+4luRP7NxxUaeX4cWfRgJZ\\\\\\\\\\\\\\\/xRyZDBeyNmuiEllP1t4mmUNV57n2u47BHGz2EOCE1ByDTU7VjercHhL9VNIud\\\\\\\\\\\\\\\/7rQnXl8ngeQQc6FEH7DdtvDGbpDnpfzwIMpoi+gnvogLZG\\\\\\\\\\\\\\\/UqyLC+oTxsx+EsaXXfUGiU6rC01nQn2m2FFpmlLcDvbfigfbtleyhz1D32F6eUhlNRNKHIwapmQF6NKXfRH9BcuPBdbYDq7G1SY2KEkg5CgAYek3NmYXN8Qz0Ep9H0eBrkdqa5JOsnu5NDsk0JvbJt+QGHN2g17SfQLYxGhuFgfXYOgnYQsRKPQva\\\\\\\\\\\\\\\/5hIhRp0wDm1f+Jj47DeaYlon88AQzw1Bh43OBgnolEwCAUhBMSluH\\\\\\\\\\\\\\\/jHaf9c4oLm0O2aqjOMUDs79ZmvA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022A351Hpf8t7FXxfmMmfLiug==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002225bfc4366b67b0c5e873879ad834382798f46e09885a3c97e571f3671f84281d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/163.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/163.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0625-x\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0625-x\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0625-x\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}