{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ptZA4iZ\\\\\\\\\\\\\\\/ohFfgUQFWtpJL8w2OCil7yZtgrjoumbnyT\\\\\\\\\\\\\\\/ZmCa2d3Yk0YUXGX\\\\\\\\\\\\\\\/hWXC2OVriEv7VISeot+OxL0qOumWiOU1YwF1AMViBrXj02+ePoqdPF+IcgbnCmNdhKF6hOqH3008pMJJw7mG9UrdD17e32kx1lbExiCdlYFc0n+CkPlwWhWimfOOeoKXIOM6\\\\\\\\\\\\\\\/MmwXpL9gm75oyDWi4VQzUGUzjUPKCP9sGqJYtL33b0vXlsGPr0r9eeUk+wGiIDXX9gKtPIwBA3jO5IyBVQOF7b6mDdma6OAFLf28C5RkskfbLezv8koX+02Efh6CjH247Gsaw6egJrHYrZu9sOKy9Z7N15tJyR7d4lponfPmzzXKO5oFUwHEt\\\\\\\\\\\\\\\/P3yYzdsUp7XEd340PgY3lb+2R4Tc\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/PtbnSgZ8SGx9q4qxkWAz7OtF\\\\\\\\\\\\\\\/uih6IWbIFuGRqqfa6xgPKiUeMecMtQ8AlUgle9vLM8\\\\\\\\\\\\\\\/wnkhalWOwSJ4Asx9UVjwR7lQtfTvwpx\\\\\\\\\\\\\\\/F1VywF3TZ2VWXkoiTm1ZvlViHb4fPJTJ5zk7Sxrjms3bOBKVUj4YWljsg+jzxoejniZd3E3VgxM1c8Q1XIjh5VQx9sCNujgykoTQpDXCfgUZHOZi2P2PTnvUxKSrB8AwE4nMUQnsoGgU18zyIQiOS9ZZTwFAJUfDbWST1z4PaqDTAcfnHoePVShe3jlY1h34185+7fjLVtiFyM1mT+p9nwzCLw4JAslrKJQMw8uhkJl9yCRFtPGHPy1522Moaea8EdX+nKeXvKdTzuUqLvDowQTSuR3ta9TDoWZyCboouqPaImhkcml7W+2\\\\\\\\\\\\\\\/U7NjQorQe19QRQTPnvJCLPefLH4crMpRN1CjJWd6SGtasQwgTL6pSY06iRWVfo\\\\\\\\\\\\\\\/1\\\\\\\\\\\\\\\/jgdoJF\\\\\\\\\\\\\\\/R9qiO24LcNiVze5CulDOHaJRkvlf6Hvzw+ar1ZGIB3EH89yYENrEJbAxzzpxq5Vn9YbdX7rCHRuOkD7u703ZzcWyVeAYkfrDQ9B9bqz4bTPug5XFPgGv\\\\\\\\\\\\\\\/OJC2C\\\\\\\\\\\\\\\/tSKTIvRQlKBZQ2ykwp91YLqvVQGdXnDcLCZ47VYbAYGmxXJfdpbNVoj6qJo+Z7wrtFqrltqaJ1q1sUwTDmvM9ds7xWGn9XeO27VbgIhHD1dZNTh\\\\\\\\\\\\\\\/Z8oPTimWT8lYDCmF3\\\\\\\\\\\\\\\/t1\\\\\\\\\\\\\\\/pEab9+FDBYVX5j7NREO16mWvEMUOaw7qbpQiBZF+r0+G1Nx8NaGDGe6+kXpwz0cAoIrnUTex6BNQ0SEIBQeGJYWpclpXc+YMUcambzpuUY2MMeHeUziOApAmzcHJudxtvNUZ3\\\\\\\\\\\\\\\/6N3Gh8aKe1cUkrpCuEfAUTFzxZAmhPFGA1XjMUuBimvDMcmo4dpsRqtBiQGxtD7F82vVEnkHlW+7MQ0job1myDE9tR3eAtaQJSlVOAt99t0ER994xAXDnf0kPcYsFJUCido1LvuZgBmuf8pBuuHP3EyGLwVVAHMlLoypkBkENzhXJ1ic\\\\\\\\\\\\\\\/OOE3fjFyC6d95JFig8gQoZ8MW+1PCtMBsjmDUsiuH4isvgi9nmS4WSB2vV2c9SEpJxkN\\\\\\\\\\\\\\\/bRYTo8PblVO5g1fmF15WUGlkkv\\\\\\\\\\\\\\\/UprrhDsBxdDEaJUt3LCXnlGS+4jbz0QRVeYx1JlNKItSQ9ygtWt+Z+DA1xU+pRVNeSF8trdn39Pr1AWdg+H+CMHh+8qycbmEu3JKPRIVGAgLgfVgzvsKQVNT1pbIXQ+vHBRZ+QIAIm5EtimgRrvLulcpo8xYSCrwyjwWrf+cJLlItQS7u6xFPj1hzAUhzJlxg6KK0pm5G0\\\\\\\\\\\\\\\/aVasHm1jgweR1Lw\\\\\\\\\\\\\\\/GYDfeTETOIgYQZ3h6pnFQPjHectAQxpnx3D6l6IQ86AaB2UnAmFXYNwt2fOBEvFKL0OLLiySCeM5aNvE7RIx\\\\\\\\\\\\\\\/taXjyfyRNb2UBVSVRNKkC9hdfAJONgpzjiGcYw\\\\\\\\\\\\\\\/HLfG4LP+NIsUsgDBGoir9HJrGdlUICoSJCwpn3SJEptrZRS4I8SPEQy+IbIaskgEW89H8btxbFlKwwAoLHYsJXwn7CHlySukOw1vzlB4oN4ADe1jP3RLanG+fPgWQ30EO7k1S3vaMzsysfZcGnt+IyIbXIbLxDxsPvdlTE6w8yhcLDWeMrfnwoMIMYJ2d5zoM1ioiBUZSePVw5zGU9onffMzNSH92d557ZAGGdEU\\\\\\\\\\\\\\\/VCHMzH00bxf8OW4tli1KVg0WxxMagZjwYc3Lr3NhKLWjkeYccCBDuQ7GGtmvra\\\\\\\\\\\\\\\/YO2A+e7NID57q71JXTyXUwhYJxwE8Hq4qoUX+TZ2HiGUKSvmAXrgexxJjM91sSW21hmVcbd8LpOQFGAJ4ajy4otErcKX0rZSRHQP3ZooJwbtkUZH9pAM4sWAYPjNEj\\\\\\\\\\\\\\\/C1MQJKiBUshlbh2hOpXQDxpnMme3Jd6Kh6zD3B619833uWsnAWZrq7hDteymoltu5jMqs2MMzZKg19MXwU5w23KS8vBe2bKxPD\\\\\\\\\\\\\\\/LdoEiAVDW\\\\\\\\\\\\\\\/3IlvWhTsIjQll2XwTX40BXMtGFo3j7WLlVilJGzidXCdFSzMar8LH2wnwdhIkVqH43tEIJRGrGcHd742n06yPcSFkyX++mGXyXpyc\\\\\\\\\\\\\\\/YF+xW\\\\\\\\\\\\\\\/RFtAhDLuVWxZdcHsj\\\\\\\\\\\\\\\/KjClU8Yr92+JX54D33PqzhjOYsd+B1fX7epiVI1EYgVAWv1ZxmM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022x6QWKziHUx8MhLqjlETHeQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c2ae75ade1a72e4ff1ddaf6e2a782c281354e6a5fd382da378e805fd2398004f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/213.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/213.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0689-7\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0689-7\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0689-7\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}