{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022uFe6aqM6pMmO+aq9UGad2Q6dAPf9jW4sk2j3J2SE8X5ote8vQRVSLsHFvoYy6EVqg2TRYYJdTZIK+j1zQDuT7DFhj0N+dhsTcC4Dlqkqg8USQCfAp19en48I4fdXom7LVzuKC21pfkFj+iw2jxvh5eZf4flfu4JA57VNgVgRHuC\\\\\\\\\\\\\\\/Ft+t9GKONQXqhr\\\\\\\\\\\\\\\/8CMALUhpH0wax0cfST5zwWWFI23ez8zVvFBsg5qSQxZKN9Y+H\\\\\\\\\\\\\\\/3LMFi\\\\\\\\\\\\\\\/5wI6z768NDhh4witg59URhfrAvIciNcjKFkEncCCdlQqawAgSOHMSHQzPuFHQhRVkJOUoaCqnzOvSXhVgu4oMpw6fTwLpIJmRcKqPpPOjg6Kb\\\\\\\\\\\\\\\/UKkrNtPQVNihwiYi6Hv2p3QIJ7DTSWoZ+dfopAfq3mqft1aIz0srR143ncmGun6zHfSimORHEPIDoj9qWr5XqZazqqtaTXUyEGH2qy8ZYi3YcUMPwAnPujpuglPWmG2ChJb+LNzidwLfoxUnV3EfPBLZnprR\\\\\\\\\\\\\\\/DxbsXeQKeEDKeAwal\\\\\\\\\\\\\\\/KbXDyv1HIM61Q34J1gjy7XPPaIYHrp2nooZaCmpjSMSbAE9Hu4Wsr47JW8cmBfQjeW19dImDKjrUbYStN5aE5IU118eaR3SrN0u8VqCzELU040R\\\\\\\\\\\\\\\/lZTyWSqtDx7QeAyduO2AY5w1FGvqiaqbxaqXYt5hsEqvNLchGNMH3uPNMgihxOFFmR75JU4B4cogNUiT\\\\\\\\\\\\\\\/lUmYrcTtDuH2I334PUtkGgN+IMK0NFtwI9Ftr01UryiEPD3Y3z6iHZNgUZaWVNh5buJ73sMNHtHBT462zMuDg7XUQWnY8oA5MlWN\\\\\\\\\\\\\\\/bHE9USsQVaHcu0bhNq5VTynF0SGLsxsLPhWeZYtFeMiwoLN0Vz8caD2wgMOeiJ\\\\\\\\\\\\\\\/IJt08rYfzAOoGN02WCHahoEcMwepxcIvRjIz1JZsHnGlt4c1YjlFHC6zYxI+wXSt3qhLbPq\\\\\\\\\\\\\\\/FmXeEXCZJOCP2mUmnTd8GxKWurNLFlFTFO3+mxS+L8grIkhVgIpqCVEuF2brSZudSkiS9F72TJI8XV2WQQhzjqWweVGn5Hw\\\\\\\\\\\\\\\/UX\\\\\\\\\\\\\\\/W0VRtuDvZV+2\\\\\\\\\\\\\\\/vds\\\\\\\\\\\\\\\/6cXbbixBoLir2sXwOQiLrC5VANJ+Q37dlEK8w73cY\\\\\\\\\\\\\\\/zHajUITDi6DvhrYXB9fD1QSaDY5UHpQKncnnMtcJg8UloV7SSd3d+c59yXkI61nbbK3mt1s5JKTKEMxjz\\\\\\\\\\\\\\\/v2M+JUU0icINaQaR3\\\\\\\\\\\\\\\/2oWiGL+o6W0jNfri9saS31Se8wWqM8RCbmF13MIGZrXv\\\\\\\\\\\\\\\/mWbCpVNahzIUrg9szQCf5X1jv6c6YKhjdeOjVGEZdSukUNjUnQFwOw4OGC3o0Tg5DWMqpIZmj4nBlikmw3P4Hx7mpacHrVRhD98SS3MrzYPqN2AT7vs5HW23IyGo7sicnBy7nBsQux+IfSPkFYd4jRzgK3iegQLK8I08LKfarZtcLh0PipSFHlOqFYKp7C9v+\\\\\\\\\\\\\\\/NhS97Dlybi7UADNZnmoOa1tjaJXf45tQr7ChY9X9kNBmxIxRgaS6RKlFcCq3GW6zduxnZ4kSvMy42S\\\\\\\\\\\\\\\/rBeFs09RiHdR0gWsi2vVWDrEcbrclBcw6dFnolY1tGFW4IoVqMYb\\\\\\\\\\\\\\\/WbQnwG\\\\\\\\\\\\\\\/imtUMTiOi+LrasSef\\\\\\\\\\\\\\\/3e6\\\\\\\\\\\\\\\/Pxh\\\\\\\\\\\\\\\/f\\\\\\\\\\\\\\\/RCGuDiUsd1wRNM5oJ2F762SaXD04derNqaTBAEHW5PwnSWDKrFff8qV6S08IRmqdEbj7QDPpuESTYdzausCPyXozTJBef\\\\\\\\\\\\\\\/D1QNDAMxtRsLXofJgyTGU3H6KswqLXkUVqZj68i7ApFB2TqEjZWnleqYRbE1Av+RyrshTIDJaa9k+ZDqU+oxm20+KgM7JrFeQdU9vsOlpZ9hQ1mX1E73ef52D\\\\\\\\\\\\\\\/rcYPt8ZPQugA2HTZsoNEcU\\\\\\\\\\\\\\\/o3qxYcaHrLJKBXnZJGeW5ilk0X4mNupPKUZYCcUvGVGslTSGglTKsLVtV+SohLFY18MKqQ4mzlFIBIf1Eo\\\\\\\\\\\\\\\/PUT1lMCTkrl3lcBe\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/0ksbEiAyv8EcPuy0uCgAQyiFGOGo1Iu3ZkDg\\\\\\\\\\\\\\\/yGgtYYJgCSh12Rt0nvwYrPIRqUvUQyL+haa1iOK9T\\\\\\\\\\\\\\\/dBiRkXPxfkDBfWQ4qG8Wjn6ePxS5Z6JryJSFz\\\\\\\\\\\\\\\/OvjUm2be+xBWA+BC2gDgeuQLvrJEwOtBTapMC48LuQxPuB9Z06DCE5HcyhC\\\\\\\\\\\\\\\/SiSR6mfN7b3OVsjfIb2usoxl39kgJ9kNKim8faL+ZTef2447C\\\\\\\\\\\\\\\/NIHd8EqPsKSXyCVUMqOCiU9Oe4vo061+OoIgnmG63tXm5z+qoWKQYM0SHe42t1l52XqgrQP9zEhfYcuv3JxuFibhpV0u8fSdzIesKr5rqDgglTtC+\\\\\\\\\\\\\\\/Qzfwd\\\\\\\\\\\\\\\/Uv80WUPcNTFpFEOGt7HtXv+\\\\\\\\\\\\\\\/nkxjYTxuMF0dAi3sSfOJYytVJU2xh699iJRaNzy7FLND+mhQSuwRlVxky1QMw0ZUiy4Oq13wPbJrT4KTW4ixUwXnZ+ak8eA\\\\\\\\\\\\\\\/iRIMWBSicv81OK6Tao+QQp72yY4UaiLGWvs7djm1Y33vIiQD9XhdyV85ga1\\\\\\\\\\\\\\\/bPebxUxZEFHybgdf26pE78FjbBmGNsPQUHmAqQJ9acvzPhUiN9oNnivDElUmBpczCD95ZCExhlP09Q84YdPh0i8F2IvoF7jAjlTHJ\\\\\\\\\\\\\\\/N89gMH8z2wGaw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Xw1p+6ZXTEDz32QWUDlyxg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c3e7fbc522eb33ded872ad3705f7eb674b834ca1787a1bc750abf727b010595b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/170.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/170.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0661-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0661-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0661-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}