{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00226+6czeKWzfDVcNt8D\\\\\\\\\\\\\\\/eZjt1H6dBoAXdPmK4QjjQQ+kTjSytjCEJM20HNLHZ2UnVjPmAoAqtO29tFTSUe7BIGbL6JXhk2W5L6AX\\\\\\\\\\\\\\\/voIuZZGaZupaeVIYV0MKSQUYgnYG1sKTZgk1ifkTmAhU5c0mkFloYYxGww0be8pvseOpcBchKEYW89x4gQqw1upXsR7agnLTm88FqonANQMZBaF7j7HPQ8HPu2gFuWVTEDvwBK56hhsmd3aZbSdqahso9I9mSHLt8uKVK6TZ0zOkPVRbHCTq3ssWPM+ieqn+SYDs74HxMu9E7A4WdohZyub9wUjIz1XdpiH6rcRR+3Zv8QWKptJ1GUmXpEXsxz2hZTBiiGj8iAH0PDfMeOWrlQzeVoI2ZbUgt1pm4zQ38hN5Zz3fBtHRLTq811cLKhMzPSTEkfLoM6BSEzeDJt6vy7ln7YiS0KDR2eszOKwjEKeDBSb8pMIHmrRwfrHS4us\\\\\\\\\\\\\\\/jctKkBXfYHFqdBz5blZSHl+yYjCFVnbv\\\\\\\\\\\\\\\/n1XSpQch1czC19aE6PRufEOvWsYFJDlYAhRaBYeSGtzlyljhpd1Qcux+PoUPtM4JH5P7vp+lnkrqAQgRthvlKjIUOKnw++4tymPNIDk2VjDKFI+xfu5yLgWp4x7Oq93fesvSO2m9HAfx9Wlsd+yZxQNUr57pcXqtX89FEecY6q\\\\\\\\\\\\\\\/EIF8qcglaVtXni8MaNqY\\\\\\\\\\\\\\\/VUHj\\\\\\\\\\\\\\\/fBPxk0LnxaqO0uPMZ9Hc+9JTwI64EJxfl79nJQ37ZChy1v4CQAcAVPoRefU8IrU2+FP1muSUXjKEF\\\\\\\\\\\\\\\/RD5diT8i29RcvGrRzc\\\\\\\\\\\\\\\/pkK0p6PtHqlrSnjqxJHz3A8Z8OlizyzWtHmdbgoEZWig0BuRMMx1Y\\\\\\\\\\\\\\\/lzzoOAaccYjRVX70h4Zk3alEOitY\\\\\\\\\\\\\\\/nkhp5ghlb9WmmLoM834mYUsHu0phrDzuai1DODEL\\\\\\\\\\\\\\\/TuQsTkkFYuv48HDtWWHpZ7gQu4XeIVzi4HClCAIHMST0Y\\\\\\\\\\\\\\\/f3jMyqdQ7qHXyjUXWIpa+nlrh8TTfM0nDEEODVv2gZVwYwIpNlFVNx2ZYT6UUriYlrHDXIdBbX\\\\\\\\\\\\\\\/eN4Sn02aWYLLQFQGrGAVhCf41oCmiedKCIQmSPQxfzcciGoOTrFyqWuSCD3YuL9Fp5VO2HV\\\\\\\\\\\\\\\/SFD1eiNHGW7uEb+7AB00xvdhJUep8XWWSDIFmOcaI6dGl\\\\\\\\\\\\\\\/fnFzO8MZW9Zg\\\\\\\\\\\\\\\/UiR0tLJzFVBtyCrOJJmkMxmal1Fs1byiBJUm2jGxnt9iqE6VFhFjS9qWr1a8jKgTtqwDAoX6oW2Y5gYIx+feQJX9hc7p7mKaLRslQRgJ+RAB8Yja35Rgi49y1neKCvo2H8WlaZH+mnGRdNz\\\\\\\\\\\\\\\/jTE5PlwuL218KoTYKoGBNxko6bkLnw+vZ6nHoAXH\\\\\\\\\\\\\\\/Opj2qNOiwV7\\\\\\\\\\\\\\\/C+R4QIc8DvQyybPA0ga630Ys\\\\\\\\\\\\\\\/8QK5J72xmaFGMOavxAvk25IVfBOine1uY2s6cOrTtjF67\\\\\\\\\\\\\\\/J5\\\\\\\\\\\\\\\/ltrKwMe9rJUlhogNAod7UmKrvb9f0NCnDkgCmK\\\\\\\\\\\\\\\/0tS2ENb7RHTjuxR0ieOroUOgpLrxoV4a+Grvz84C0gawirP17BoTPnkkxWi\\\\\\\\\\\\\\\/5ZfScrY7iIUe4yVdcNIvt\\\\\\\\\\\\\\\/gzzromP0Yp9wCBzbopJrdTxO7uHLSk98dL+v84eh+5xffUUvgHiThb5QiGO4JA5BksYAprhfmowQ1TlYgNQ9yjSmsLzK8CEwV3Kukindm7uC0YiZniq4Ky4lPdjJa5hRincEBjLhDRasjOqbYicF3+UkoRiuqUmZZuNBh9nzPGWQemJm0s2WjODRm64kOvkFO86jbK\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/F1pEytWO8Jq+uJpNfKIIigJ+GijdrVUwMfjy8HJVL6iA7zNCabs0Ley9U7DLb7wFM8BOr7C74dZn+joYfOgQvUfSndGmclyGTQOPF9z71+wlNMY6yghP0Cjs7vG7vWSlqpjVWqAqD0NzY\\\\\\\\\\\\\\\/JtPL6STX6NNmiZLuGUP\\\\\\\\\\\\\\\/oFUYuxmnjIH80Pg1uGNpY40S2kIki6Wrz7t4eRW2y8EgkhGdxapNGS5DY7Nmzml7rgBp+cnVn39lqOiEkKlyvoRhdR3d2vj5r\\\\\\\\\\\\\\\/tCWOPquXLK7uvpwMJyu9HlPsG1jGzXme1b58MewfTTLhVtcq0qMZE\\\\\\\\\\\\\\\/a0\\\\\\\\\\\\\\\/kXZVl2sgTIKfvtXraKwJpVptiKsykMPclVQqAY47iwsKUuKYTbRfJU6teWzZXZcZOcMgPxZAPQwEqjc4LFofP0cufK0kozWZ1csE9m9BhSbZCUJATmIc1NlSKG3AtN82qn0GzK+9gThYjQktNvbEG2gl\\\\\\\\\\\\\\\/QLcl+PbD+E1004KZd8HkOeRCNoObWEF0\\\\\\\\\\\\\\\/k3MokdPFpm9ArNT1gvXw806yS27Mh2iye783lRJgtmXDfVNY7zNUu\\\\\\\\\\\\\\\/2IbvPQupCl8iAG0gOhFA0cec7sD0N6sDswWLY\\\\\\\\\\\\\\\/FLjUN+CMQeGDDjxzKuc69VNc3DgCnUWnmL6cUaMidNlBEsJcygUlClnJjJu7r2oVOsFASEXX1mzlrz1RnNo2diSovS\\\\\\\\\\\\\\\/VldRMpk31Q7eq8W+AyTCrtxgBylygsGKSzGTuWomkZGmKVZyBZcJza8QgCqpRy+GyTSejC08thc9V9gvU+xISLtGRkpuZD5a3t4C86xaiiv7dSb2D3gdDjEoN7+lec8gWMbH6aM+ezg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022CityB2FAoMKLZmmTBcnIaA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002217f5fe2f7398a0479bf4565f10ea71bdcb65239d5fedb4bd732fc3df5af3e2fc\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/209.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/209.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0685-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0685-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0685-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}