{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022aivUaD1kYnW6k+Q2sxz7Rx470mRBRc41z+D5WCPdx2oCI36rGcuxeY70XWqZ0MdN1Rkvzs\\\\\\\\\\\\\\\/jq979KgjHeNkRQw+zjEoDKXyTcBDpGtiaylrfwVVdC\\\\\\\\\\\\\\\/tJ4\\\\\\\\\\\\\\\/VV\\\\\\\\\\\\\\\/zfYelYX2irjcWT81igkgpQXt7WiFke99dePBIW0lvC0gOH2MZQqAov38luCd8ujFv1R7rVaIS1AoZBr61T9zWKTQcYnmXHt7izl60e0RFuWc6hpMWND4oEp\\\\\\\\\\\\\\\/4emAy5WLtuablKrqxqJ156l1xLqCZx9S7H28ezDVJx2HWXujGZTPfSio9MjOp09HXjcZunhdhhtHVIq8KwAHI0pCFtXNdIAPOwuEeWeDousgQc50oIOu1YImukB8FOoXoLwtUajkEBcYxHrj\\\\\\\\\\\\\\\/rX4EbxlSZ95kFr4ex6h6wvuubl\\\\\\\\\\\\\\\/kt\\\\\\\\\\\\\\\/ZRHyrTM+1jIu9udTC\\\\\\\\\\\\\\\/1PaVFZt11oa9Vr6Mew7WxtP09sS96BkzZm1LC81DeVINfRrDHf67UZHZbm6brKnF0903\\\\\\\\\\\\\\\/rMmd\\\\\\\\\\\\\\\/3t1HrCHLeA0YdaMco0MXfjqY7zPtYI8EES2yHaSDvTCpyy+kISkXruYaci7X3eb38TPbV4f27CQY4+0f1Llr7aOPJHSzzWG6mGCiwFgb\\\\\\\\\\\\\\\/ZKu2gw4P0q17vJlPmPrf5yIqm8yPk\\\\\\\\\\\\\\\/V9PXubE9YMR5D5QyBWJdHUfrWvjLpE+yW0Z\\\\\\\\\\\\\\\/T4WwJf1yaAaBr8A0IVIsY3ViHt5ZqgEHGnNRPG6mIA8tXOo9kzvtsrb5hrQpug\\\\\\\\\\\\\\\/SPyMlbD47LrO4iF9A+Ni0Dnr94D14q7cXtfUTG\\\\\\\\\\\\\\\/fXMYIbiPytJVvLSEwMDcMbyz1FyoWX8iV9i6BrRVKlS4fVrrve8x7etrsFiJwrPFnSAlGmabEJ\\\\\\\\\\\\\\\/kveTWvYbK9sRh1g2kRzeqMjfiuueaqCYfuoR9vVl4wbxU2nnJu\\\\\\\\\\\\\\\/lZyX1lo4Aiwp5PE7JKjgG7siNaPhpA9ZLD\\\\\\\\\\\\\\\/ewUvps7qZMawfUqcJxfD+f3HRJAe7Je62MJLDsXOhtT0TgE02vMibYRF4NFAcQ860L0wCMXBGHEL0A3iFtuzGUh+RrkkZnodrIXF+6lT5Hotep948+MOhGtc91Tpt5eR5U50ayGqLyy8KFOg26ysCYZGpirloMbNJ8wBEUl52YYmF2pBXZnIY\\\\\\\\\\\\\\\/v2ANxtbq67zxPuipm29fl5apgo3Of\\\\\\\\\\\\\\\/8AmkLefiCeDlDYFYDfIdm53ZOxa+E2inqizpk8YK07UsXH6josp\\\\\\\\\\\\\\\/DGoqvVitmNeZrzGAlLXgeofEyt4J9sTukVNqtKj8s8K14GmvDjIQmZfP0wJkUP6\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/TIL2po9Fj\\\\\\\\\\\\\\\/1q1zcet\\\\\\\\\\\\\\\/ZVmqULAxcJaPARyHQfDwYrSf+Ki1hrR7g\\\\\\\\\\\\\\\/2nUrYzSTfF9L8wjXqLIHNxMJEWTsesUKCULod0WXRD4zcHuJclxXQAQi3PXTpr7cjMMoD8TDH0Wkb6m80Qp0bLVE\\\\\\\\\\\\\\\/IpDt4k2Peni+wbxO+PYyXHDryD1PsMO4sD6ZtLRk1lGwEhQCqnWv6xw8yzbwl5Yk6q6ded5iwMGWELFwgLJ0d60mhLUegDolZrag\\\\\\\\\\\\\\\/QrT9S0Wu9pjL4geAK1174aNTy2JpIZfZf+3j5CYIlyevVxrY\\\\\\\\\\\\\\\/xcpF7IKfYsZI6tPRK08tISaA2G1mTUon0KGmnCyLk65fZwTFlU+FoV3mrtrUffyECopNHLE7cE7FZZj55HJCxt9RNrRiMKXP+PiN9L4pSrTGWELviR9btt9xK5UnskGnvmiSt\\\\\\\\\\\\\\\/KcKAWe9iyJ\\\\\\\\\\\\\\\/9NU8TV7A8bJrg6vlEbesBqfNcvS7yEsNMdMpvsA+7d05w87JUutLgQmyBwBMzLpdoffqtLRnpsdCGOlhN1yXSgD1TkrCkTCZ8MC87qam43389QqrG9VZM0Uf9qWRQ9ojiJ0VdPHIhrfcy+Itoy1j6C0vciFe9AkOFYTR\\\\\\\\\\\\\\\/KycRKk4aLl\\\\\\\\\\\\\\\/Y94vZzVdvHAZ8D9KGO1rXXiSUSczL6Gz+pEm3Den3\\\\\\\\\\\\\\\/f2agaF\\\\\\\\\\\\\\\/pN1CMhhZGefthoHG0vrDh8XsKnkKvwUTRqCqSdUuI1yGsrxZLGMl+WOeUpy2TffcvNuR5AUlY9X9lj5bx0MEjMugNnMm2xCa1ZEbffF09hjIiDNlLRU4RuFbcZTC+OEBxgIvIYcx\\\\\\\\\\\\\\\/HkGUplyFfDa8JqvTnILS8uA3kM5ybpY7hm30d+UWv9SPcZUuhm14FJzazkRD+hJhlDLyGgKiEWiCZeOG5Q9ohVi1LjGxSHhZzlS3mPkOV1FD2rBqd5ekXP++nOo8fp3asKZLosVpG605g8ZqtVLFjMMDw0HR45Zu7GME8ruRg0aeO6RmQkjmBOtnyXinJ4\\\\\\\\\\\\\\\/5XgEaAPMy1CybD9h2NgH7\\\\\\\\\\\\\\\/ftWPR1\\\\\\\\\\\\\\\/kvcUkYctW8ouQLocSf8VYkr40ydDOR3O3Cv11DnpA8FUXQzPY+EwPnwNEleVJTG\\\\\\\\\\\\\\\/fGMi0WHiQRSjMWroNEfUZw46FRIwjRGKRI6\\\\\\\\\\\\\\\/2nQfmamtskpEeNpfUGm2qK5O9uypIazxDGzK3\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/4kCSxvXgtCgea3DpJU8uZ4A6bXwoxgYCKkOh297Rcku2NTuU1T3cUbpgB3shVfN3ltFvHjj9t4l66ONSdwTuS3E9BbHWXGWyJbdFIPU3qjoKe5fQ4dZUfknbXoiK+8UeSjBmOJg\\\\\\\\\\\\\\\/gWlJZ6tFj63oUWPy8bfprPhweI7jMQd6feb9EWk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00223\\\\\\\\\\\\\\\/N8CjuocQo\\\\\\\\\\\\\\\/kl1Tf2Cu3Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d90799dedc5aae857882e16cb63eb48dd60c0dc3fc1731de2be441217e578ffe\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/152.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/152.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0627-8\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0627-8\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0627-8\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}