{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00229jKcgQ9zjdEmDXf1S\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/6hvuspM7EXUo7dDnIMHSUUDsnbjdrU+jOb0d5WJJM8d1O6Un6EiMcNxaBmXCsUXyzm98\\\\\\\\\\\\\\\/zYjQ7rS3jYeOeEPzf3hqgdlBI2jI\\\\\\\\\\\\\\\/WKqfBI8jUnS0EYQft12ADkxi907v7rq5nb0pFM8M390OOEzIkP+wnXTpPwAFtiDFQKwXCYbtdBj\\\\\\\\\\\\\\\/gIQRbI+SsMoX9SvyZA23CMuGq14QRH2njHbWpr9w+DeufBee1GDZc6YpmkwyqX2tHTEG0juEa9gowwn\\\\\\\\\\\\\\\/TGdWlZ8LhZeRFmH90euYWiJMLPIK3AvhsToPvUNqPmONy3KsoAYfZjHHIm+g\\\\\\\\\\\\\\\/C9Pur+QLBOaW+mWeSWvTFCIAURaP6RarNzlhtiEB4VDT66KVveUvk907CvKTPUPrTocZ35qtj6SKZtT740ssVl0XPaEsVawBzmd\\\\\\\\\\\\\\\/ErE\\\\\\\\\\\\\\\/J+tfffzyWewzefOFRLME5wpjWVDI7urqcH5TTWyHgmnLVurEIEJHTymFP4WO4pXxYRH1Nvee7p66KZHSpFMzvYd3g2UAF5ig2E5OJGLBWWOCowmLmL2cxZA4sgWpXsb4Yh6wonoogKIVi7mMEIdRfOpgQn\\\\\\\\\\\\\\\/l1f9tpP0gaxahTIk1BKaBxQyPdAR5PISBoy0W3ywIS8NTb8wGdhGUlXRWpYb8MjJvEyt8LiNX9Zr4CMLDWcNrg6p7aRbUiEdLAGgPcRJJOCeiKAuLzjXYHMTe6KtbwzjD\\\\\\\\\\\\\\\/629PBz35mSpYlIW3Fgo1kHm9I0zYyF5dfllV1nP7scrTNkspbAmcGoIapuMoeW1+ZUZ4TgVfQfNwPcVMF7sYLTyNbHUTjp0Xe0Zf182KbiwkP3kG\\\\\\\\\\\\\\\/taCRKDMxa1ipaOIhWW3ybe9h2bI6Ty7fgKlvkueNpxEGFBf2YHfAoUFmdfgwYt6FcpPVSSKJqo+Q3fZnIrpD6IvRy\\\\\\\\\\\\\\\/HhVTBuzZLjHiKAxFRU83InWiLftfT\\\\\\\\\\\\\\\/Te0s3nDlonSFHxupwIr9losglccBnYalKbaz9onKVH0kmSujIqr0JevW9e4kpwtniwdUmj3lpDXCvDxY5danyR+PrVp\\\\\\\\\\\\\\\/SFmKh1NhEcsN6X+ORt0J\\\\\\\\\\\\\\\/jWL4ac6lyZQ9A\\\\\\\\\\\\\\\/ZY\\\\\\\\\\\\\\\/pxQkbGBFdX49Lt2mi30qsJ1HlHMNSicjrZpPPAgYJ9wPLWjjOYPaOFkCuADBI6T0PHv0fp37\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/qMVt\\\\\\\\\\\\\\\/8TYGVZWLW00CQKn\\\\\\\\\\\\\\\/FkOIqZO94Su6kdwH+tGetrydBfRh6Mc4puyWhoIzYRJzuzO5uC1uHzUGHMuaKkvGyEtGiRVD2ulTdYUn\\\\\\\\\\\\\\\/n5WDPI9HDZxwvz42T\\\\\\\\\\\\\\\/fSvMHDBDtgsLdUr2VYk+UtuuaeqelEyH2UaoHiHv4MsTTiWPWzMZ2WMAM3vjMWQCCjz515Gsk2M8K8rnA24JxBNxfzsHmVE08BuGZIJcjZco8Z+XhD7Ey24Metc6tKirjLB4AMaBgfEnOYl6Onh4Nr\\\\\\\\\\\\\\\/in5yD4wnEA+WjvPyJ0a+k8cg6bbgkO6kgQNbPGaGv0LPY8zlHtPzjWw\\\\\\\\\\\\\\\/UUx+4SwagtCAn04lg0vGg9wjbEQDH+Lws+CL4Mj\\\\\\\\\\\\\\\/0gqhfr3tANNaCXQU9JYc1NZmSTqupWImxHrW+II25YWE7WKh4iAYE1ksnLMZJlZgmcg1z2da5Wc9AK\\\\\\\\\\\\\\\/eQpWbuW08QT8bjIdElGVXjslMMHoSC9LFuidiyi7yCdjJyGfTt5ZAJqAPzC19fp4sT4Jd4oho3bBsqAMpRIuB9x2SomqJSvkX3L880gTQl6u7ntD4pjrH+cC+0r5axoP\\\\\\\\\\\\\\\/h+yvrHNkVbAGg+MpMWKfW9\\\\\\\\\\\\\\\/eG0TBjXU4hWh8sB14e6dl3vANPXEdOuiE5BqprjsVNRTpNU0oUTlOKOD66xNW+DLfabR4UD3fEyJzsaO0ODJ+HcT3S7McNjfk0Li0vdIE1gh01m+oNZprZ3x0ntMBr2S9mNynTb37hXjx6KGwMh1kie9KO5A6GUxgLle5xM9GK896+UuCFEftDWQnBbBg\\\\\\\\\\\\\\\/JDqILTLa19fjaRxrnLgTmIttEVaD9yhB3j+4d6IObUZ9K2jtIAMuB5jCJ+t13qedYV3roMxPssESiiXumWflrd3Dk9Qao+i0VIyKz6\\\\\\\\\\\\\\\/WL2lnDR+l5\\\\\\\\\\\\\\\/zc8sarWOQpX8M4FqITM5vCPXD\\\\\\\\\\\\\\\/4BEBjYz2Ts3f91Xzrjr3WbrSbO9NfuEKya7dInU\\\\\\\\\\\\\\\/moGEhxGFwrjfeRs4le5Hqz493cbw5K+4r0+DJH9oLGyX8jcI7xAWKUbqT5oVbtX11ZsUgMDu2+qHSUHbPvZwja4kgQxrN3cNr5BQteRPsePeDBkant6ZuroAbs1TrnXtfCXMy1O1490oR1GlPTm4oubnDz4YrPcEwsCsHTdhQoenlfFDDv2Z4sAkXUEwqxYjxtDSsT209INZDOAD5S97V\\\\\\\\\\\\\\\/fmo\\\\\\\\\\\\\\\/aclBhDZJBySKCx8sgmbdAMMDSDrE+SJspSvI6DWY\\\\\\\\\\\\\\\/G+lOiMJjnZPLA5eaxOfUuM8hTadvTWcQxDBoiHIYZToyUn3SB65mmap1LoQ0o0m5zmikPAT7GbyzynE0mqcoUzl8iWQHGmSFzNz58FE8fk1ifRpyxUb8gZ+ezJIZyVaPlDDFyKOh03q7cJXMdFThmVJIRnsUx312SNFRdKC0AJMzwUp0XX0TkevI47hpLwYpieRHVOjpQCMnr8Yl+tr0Odsg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022shaBRqNWwgEchxwZNDOIoQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022568516f10d6a30211cbc3082631d78532379bd29fded0b0fd40eee5f06e03edd\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/105.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/105.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0586-0\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0586-0\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0586-0\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}