{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022yhh1xxQz9EkWuN\\\\\\\\\\\\\\\/qC50IvMkMrg4+vJzX5HcbiaCoAqIbwIDzbleX06r8aLRqKLirc2W+xTSMbVLW3wl0mmxPZmSpuesS0+ibEiB1OkQM4uYJnbkeCN22Iv2MaBanK7mJ3sb4rissOFyHg+lxbG8KHKSP+zhgy5rQuJ+Xm82xWyYoCGfYdZQdmbpI6r9DsYDKSf5DrzL\\\\\\\\\\\\\\\/3hvWJ7sRTz1SB\\\\\\\\\\\\\\\/1b4rEdoJ0ji4yZVMQl9v5ylJ5EiDxBXp9qy3191XFEIunVuB3tA5lbwjX4Of\\\\\\\\\\\\\\\/IKh+7qIKs3XOigfkGN+\\\\\\\\\\\\\\\/Q8Jwljw84lqAj+i5T5eOx6muI0imbVPjtrG77NlKvf0WZSA+GuxOLBfzB7dZFvJAxrdoYjJTNcFbSf+rTZxCD3tVmEbNTvSHDH5REqFVvMTfdO6e3TVaDFjSIVKV0PcYfyj6IbO9SvJrrXHWAAvHB4zk0hsQ7sc5mJvSX06bphZfzxumPijYquEMbGicGzikiFZ4DA4IaEtqSRdMqrvGt4oXRC4ZMmgoeE756CsnPVwOI90On2\\\\\\\\\\\\\\\/gCt5ltvUxn5J1zab15WNGNMljp9OqdhwIYDvu\\\\\\\\\\\\\\\/LL3uvUeDXs81PnYAAoSkVCZFZJlSFMe04skAY5nSqY3OcA0tna4z67n6vjRAmK1E2XvltdTSiTJWWqTRMMkaRz2YAscAk6MaTbgZCCg5ToqtB2E1rL67N5hCvYx0HBkYUC6TVY8NqUY6pHWOZ2RsFs1W3TdLE0fMfibxlVRfqEIglUwU2uP6HtuHchZx\\\\\\\\\\\\\\\/O0hwAkemukMmR7M9uFqCLo8n4yVi7W8TS67TzlsOnPLll4hIqDZcd+jd9T2f8uaapBxwggaPJSanWs0qgLJCbVl+yvL2wBmswZrR\\\\\\\\\\\\\\\/dA3ZBcFB\\\\\\\\\\\\\\\/PDN377KOuCigYklAngcnocFsXID+dZgukoIj5dzzwO\\\\\\\\\\\\\\\/P26IrXz6oVQvUzXcKNO2qbkVeHGzEsTKYsIu56pSt2+8ULVV3Dd+MswlREuL2mDJKRPc81wj+4nDmMAQeNCHIUO\\\\\\\\\\\\\\\/Xq6LoR0kpE7SZN4QOQxvebIQDP6OWpyh5sRxRH4Y8ObqD35nMmfigQECZBNyDCrxdKtM64v\\\\\\\\\\\\\\\/z0eHtbzPD6Py6GqpCSkyPUl8QlNIbHHZ58Xf0bPJ+BO8R9UfsR8aGvOrBxExBeNOepnEzY3pO2H5tybMT8mTmSxFFrrt97dPw3CyhHt1wSRVVyhLU0k9LRruPsGHGSn5Guy\\\\\\\\\\\\\\\/pvcDL97MW7PajTNHins\\\\\\\\\\\\\\\/yrqtfDhX+szSJU+auZSleKy3eOVt0EJMkdu6vDh7Prj+4TcDP18DgTtiy6zlpdolpzU5Npf\\\\\\\\\\\\\\\/tVZf4RtT0yhSvHlh2H5Si4wXGT7ixdRzzTRkSJK9WqHyVCXJSY64dURV9eVxGnhwR4kr4FY38fpADeTd6We+d2y1scRpyxQ6aOdsKjYM2CMzivfeRAK0arD2GWxzX4EFUBduHIK5yqfKMxL+P2E2zq5mRT8whSFwS4BzkYQYdjErwoPP+cMZHzIbh+Qqq44zKIi6o80GhjNO+k9dUO5NxogC6J9ErP1SqeivNtmKFl9a6qOGWaorAUOrLCaTJkkodrfVSOiRoAWBz3eLSwuLGoNDVzQdE1G2JS5fgZVijhflctIS5dMLnzVR80slEo8iFH\\\\\\\\\\\\\\\/oN\\\\\\\\\\\\\\\/3Z\\\\\\\\\\\\\\\/25B\\\\\\\\\\\\\\\/c6qHVwfHE2BfvKEj0TZIqD3273\\\\\\\\\\\\\\\/mfx7WvuM0huGNEVj4GREq\\\\\\\\\\\\\\\/QP3AsKjJn75v0vuc5QK\\\\\\\\\\\\\\\/CUbiJzIDjkwcvrif8ghzTdBiY3EMsRKqWmcxOegJ7GO0SIu5PCD5LWbXetjzJBxg6hzkcfPvZnsJlwyriXG62RL\\\\\\\\\\\\\\\/HKh6ETGTT+qfvV1pe5tn2QuPSFdVVHGcIcRsWLkML1DG0wbotm+vr8riDJFgmzp3QLYnFjGcRvJcszH1UW52AWl1KlXusWAlXMDH7nRPJuEEOEJdaBgmVoQoekwQhJTMr6Zve+UVwWo2jdGgesSIDzMpaBD9kraLejiTPQo59S6E7J0\\\\\\\\\\\\\\\/qFRJrI1VFPkx1ZlWpzVoj959M3ezJrC96Zo0Ckjag6AFb2+TpUBHsqoHV+73XScy2VXSrCaNNsxTkmg+4Ga365hNCnwQlxCDiqRQi8LQhwiKyBLKSCT3VgyFEGVOevAPGjcG86kOOTxruacF9POI77+uNa74Jawb+0rFBxfBNQ5GunzkPWWNuSkLgjIWrJK5eCHRQMWOMhhXqNBNQ4CEJP696GfqNcPzlDvD+zG1gt\\\\\\\\\\\\\\\/PCCsy7qqslzLW\\\\\\\\\\\\\\\/ovF9xQmLOFUBuSuBX5h\\\\\\\\\\\\\\\/Blk3XdNRHkJ5IXUZjw27jdgMW8hOOXFaMYJMMccSjwagJ6EMIzdEOJAg8lP\\\\\\\\\\\\\\\/KY3CpXQyJ92Mh8bEqugZ9kmu8nx9H9NU1WcSwLGqWWxR6l5x5f\\\\\\\\\\\\\\\/5NPnjUhOdmK6SLJIMGNxTkxeWfnoAaNMzGkhR\\\\\\\\\\\\\\\/TtbaRfzqxcHHOpSDSUePCAlQ5TBhUehQSnr5Z4WspAKX9L2LNfBszJKv+X8zA7GGqYzM9YxUyxlU+42Oz7ufdJn6TJ9Ommu4b9Lh\\\\\\\\\\\\\\\/e3oXhmv85KE\\\\\\\\\\\\\\\/F5BltAP7PPZcDokl\\\\\\\\\\\\\\\/tHJFB3Z8jPo11o01+GEWfWXcibdPhNmHFIsQaIA8oSPg9faCXHnlMet36b8qXlQFhL9HVNjA6rUJdAtgtddjQzQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022XgppiHTVTM3o35nj3GcpfA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022891d8bff8dadf05ec861231cb6a9407e78eb629b849f76c520868fe7ceff339a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/146.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/146.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0624-y\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0624-y\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0624-y\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}