{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022oHMYTCplf2DMKd5MbGKJdY9DBsGnMHDpEcRJop7FIQZ+CGIC27pitvD\\\\\\\\\\\\\\\/l3b4UMcRyIWLQx+bf4xbCl6FYrle32bjKKXUfZoUzHXU1jsLfxyczQNHcOH7+BgDOY\\\\\\\\\\\\\\\/XmvoERjemLZ9I9CmJu8LzafVCApuzvWkTuWm7mroPi7xmetga2KmotEW5wjZDNrz8GlkkYfIr4FKrUyoLAH93fyw+14mQaBJCf79McojPyV3OSru2G\\\\\\\\\\\\\\\/l3S0Od7KRvKuCWnpQUpavItr4It4v\\\\\\\\\\\\\\\/L1jGmgD+kyWp9pCLulwWusyN5a+VhhM9OoNXknUQznRqBJjj3meTUIVcS\\\\\\\\\\\\\\\/6Ih7vDQpdEFAKcQz2SzNib8nbXICtGKp3wakfwxE\\\\\\\\\\\\\\\/emgLr1KVEIu+aYw3TSnTr01HCvesgFhYnsagEJ2H8yZvEIz8Bpsm6QI2Frv3XLwl6tKSlsEHEDa7EMBugOgzSdKcVwLJEbic8pvoU0Me5qdXUUC6A2\\\\\\\\\\\\\\\/Cm8JUMW8mPfP+dmRpJnBIxtj9s9aNBaKPJWrmB7BqFhGOOdsT+2kMnOfKW5Yu2NKq8VyYUoCTxkJXbieGb7nywX3np5KWWhKmhkpaPsAlUgaBfvwXU9eT84UU4fVNjI8Y6uCUVyrZxduK8F0q7eGG70zf1jCWjlgIUYNrNqGIwfWFjPA0BQYbLrlt7mJNkYr4dmZ\\\\\\\\\\\\\\\/EZzC4g6bf8X\\\\\\\\\\\\\\\/be9qs7Rm2CiRtC6W+uw0x1zsjveO7XfkAc9XVE4kR7CqWlDKW0dvLejfzIt8qahubG4v9t6g9j03cQc5p0fhPbOqCEuOPa5IzGLYnyxV7\\\\\\\\\\\\\\\/hERfoLe6PHyxb\\\\\\\\\\\\\\\/LRpM6LE7mk8+5fpMbQj8HflOvx2dNB092U8woUrOy+WBZz40XfMDJz+wp3KnQk5PhLlhAMw\\\\\\\\\\\\\\\/+V3FDsQEyKjhd8nXP5cibED+k+0w6aATqwiT15IQv91vQwv6l2vEvU90IduuYXmicir3enh1VNPnikI+WYTZykjThoaefGcTAqeowW4PNI5muvQPcZ5pWqsJqhuCoEyltIEWnDf1zIcuq1UtEzC28YyzhQxRQ\\\\\\\\\\\\\\\/vnA7ljM1Q6L5EcNMXzmaFIy\\\\\\\\\\\\\\\/E8jNA8t0ULmshDzKKaRmxHGWRq6uKZyadZTMuqj+AdEjlESB8Qqp+E73KavUd8\\\\\\\\\\\\\\\/5cK+HDpL9DEhttpyRvd4xa2yFxjiBztKkp\\\\\\\\\\\\\\\/I1DsdqVkXq23AqPRkJRNYP7DU4+xDTveHu+3c6sIRZsAIxfFK6eeVT9XwcQccA41iR+HsXJh+NbeisbF\\\\\\\\\\\\\\\/zQDLVVUAvDP8RsnI6X1ySK9xIpQOhyEuJLuJFqLmRC42kTNiHrMc6XKg5AIGQQoWuU\\\\\\\\\\\\\\\/beo+Et0PQ\\\\\\\\\\\\\\\/AnlNI58LlwJ2PzorKtxcigJ51CsVaR\\\\\\\\\\\\\\\/n5Y4Bmx9U5zGmip\\\\\\\\\\\\\\\/Uyalm5r+89IwSwA0VXks\\\\\\\\\\\\\\\/ww42ixpsbOZYabJJ0E6GeFMTE2tKtAaNdmT9I2eCGJTt6DCTLX5mXY+8hEIKM0zL\\\\\\\\\\\\\\\/kjJ1fMxdxZdMS0RxckXcpT46Wk5+YopfvHsXAd4BWPjf0m8lKg+aHljcwTV\\\\\\\\\\\\\\\/xArEN9IbVTeJA\\\\\\\\\\\\\\\/YkwDZAdS9hP6ESw6NHwkVLEZ2S\\\\\\\\\\\\\\\/WMrw+9teCxS8CoVXbr8xDew0i9QPJzXvo8cP9w5JTXwMhF8gjgsqV9316z6\\\\\\\\\\\\\\\/+b8+p2pISvvGrFwbV+vDb3w3z7kFogbobqhFHzwQtVjYtM8bMac9Au9V\\\\\\\\\\\\\\\/budzkjqx5SofcFejZMbQlSYlaVQKFlenMIHwmvSb2NkvomEop1\\\\\\\\\\\\\\\/82f6tSlms0K7Yv+IvgzxI3XFliXYJpSGZXOPxeF86Q7PAMlwojkiVoLXoCxInvNRsBunPiizGGj9Qc5\\\\\\\\\\\\\\\/UsMKmVczG9TdrKLYW90ey7Bj8vRWVWl7QhDLNPWqZ4xAttWrWT6QV9lgVegsgcpkp4i+6CoJchwjdlrhK4BOmumL4jt5mXCODgkbsWzlN8jRPI6hEF1l5BVhQEcJGSlYwI32H\\\\\\\\\\\\\\\/kJ5w6ClXHKYaJbUMsY1Xg2F3yI0NiAGdjj84iegFVm3qp4cDmt8pE804LmO\\\\\\\\\\\\\\\/R\\\\\\\\\\\\\\\/OSPM0Je\\\\\\\\\\\\\\\/2VnhfwzRoj\\\\\\\\\\\\\\\/y+HUfvrCMgG\\\\\\\\\\\\\\\/aSVKvB0vB\\\\\\\\\\\\\\\/viqWTP7iqM9Y+p+vWvvqSjkBut0YTndr1z3Jovxc7qFzndmXtOoi7AYFVkqUKyNKNB2bJTZoj+N5YenXn8rxEfUG4jM8LcQsSNdpVdMo1n8uB0rqRTqCDN8uf5NfgjypEFQNlJVhX46uHl0dPxj5eNabsD2yXET52XOKssYbEVfOoLmGZVkbBFOjo44Ba6uMOUv2hmOjj9e7CvwwVVF0vucuk0qm3Bz5qp5kLlHmEIVOgnW+cHp2f2EkDR\\\\\\\\\\\\\\\/B6da1\\\\\\\\\\\\\\\/YBKt97RluhNOqNcjls0cYNtj7k2veFsPRgF0LQzHwvN3YpJGy7U2v4SFRA+SqkKMl1XLmTrQWMWWffO6TvdSUy6STwlBOHXWRbblMIkklMyRt0CHp57Fl28lEQnqQbb5c7\\\\\\\\\\\\\\\/5w1jCogjA6wEpYU\\\\\\\\\\\\\\\/iye9TC1nwRSxj3RUWkUlSHXcGC9vKnDtYTk55l7r8ibOaE6R5qecb5olvE4mxYVlxjXungoJy\\\\\\\\\\\\\\\/WKVimEtf3qfyaxBEV+tjuJE72LmkPZOGNXezonVjBmF3HwMXTSphe2l\\\\\\\\\\\\\\\/pAzktn8D5\\\\\\\\\\\\\\\/XAJbE5ugC9I2deKJjY4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022GP1ZVhuppb\\\\\\\\\\\\\\\/J6NpS5uPUng==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220ff1df766a42295b172536dc5c9fa81efab6f51233c5be446ec036cc0373d200\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/13.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/13.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-018-0488-6\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-018-0488-6\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-018-0488-6\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}