{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022o6wCBm2cpKEZ3qWBT8MHZENkYbjIhkM6gM2XYEeCgeJCkslFQI9MWS6srWE2fJMCq6CCpSBMzXV0Fkq7sxdApoo0P2tUhT\\\\\\\\\\\\\\\/NZEC8BzhphHCbiZq1JiMWznLHY5ZhIbzNQtVT9B330JhvOU951cstNzqEjJz2y+yRIicg3CDO9AxlTjGysxCq2znHne2T1MM8JmADY7WxQxpAWKQBewSBWS5zbAXGpvNEzEXjbMaiN0vTmvjbNPBngMUGgYTO0eXA57tb\\\\\\\\\\\\\\\/eancBFm9u7HbWztAOPbPzZyx+PNv1ZvTds7ohbhyV7aSibSiiOOswbFQTg1S3+l+VeUM8mYjV17g6qDl2plnKdKnNHQHgzrvxdMsUOOTmove0hhpPrMXFKY78XYB3QsrckPhnTFBW+VkxQ5xZKUjfqPLGz9eMhT5is3nMw0cx8zDyh0qylaGYUZAW5f3no5cq2dgh6mNm+kwcm7mcPEMC7Ow1pNfnCaLd+dnvaCGBuE\\\\\\\\\\\\\\\/kCOwVELmCjzh5xdnreUi0sLGQ\\\\\\\\\\\\\\\/bpXmQ7zGoxSE5WGlHvOvdeheKk7eZ\\\\\\\\\\\\\\\/VWn4pYOw1e5hllXmc0dJpzBeAz8c1sxL4iF2Al1YPfZ8qFQvnExNRlPIhwJPFAZA0Gf18MfOnJAhxz7OUOmizqrNKqWB+ojcZ+CZUgRXw2gdoAI9QKtWsMLEAyeS8LigvbgZhr9RiuPmrVMPInw\\\\\\\\\\\\\\\/QxIyN7iNcU4ZdOUXfaGyHTRC0hiBWLxuw+Jvbnep\\\\\\\\\\\\\\\/YScH5NvIoehhU835cCGNRMKAtQ9tgSQgFnRCpMUCWwSRsyf1DMu0lPNTJaDNWG4IZP+owygyKiiA+8UZWP2n3BqGBucDY8uR7L1XjCdc8gUiwgfggWDgOFu\\\\\\\\\\\\\\\/PXy2Q93munfXBvm7X18S4NFf1jypZ5LOyrPph\\\\\\\\\\\\\\\/etE+g8B42qzdhxMwk8YfH+4lS7tTU1RL5eqdfbudJOU3ERhaY\\\\\\\\\\\\\\\/EG9S2NA\\\\\\\\\\\\\\\/mhui7wFiNtgHet+TafDshQSavvGtlIDmjYDzHQe5RIntafOP4vEp88gIuB4iKcxiSV0C3uV3Cc5XgLZJjVeqTiyDRuaWyj8yi2Yrmq0DjkjBQZs7Hrux1TfPmZ07IQGfgIJ8+ad6wzYuBuG4adtyzd+v\\\\\\\\\\\\\\\/5+IRX9FYDL1S5hPOpQCoDUNAdZ+hcd4dtTYTOtxfgpN9\\\\\\\\\\\\\\\/AjSEpqwyS3yR+BSdonbMj8jr3VUnxCOtHpc83A1wAcfvzV9FikbECcJjX8\\\\\\\\\\\\\\\/EvudR9Qdqg+SUTa8DhEcbWt+QmGOZhJE1GpCLUIgjvw\\\\\\\\\\\\\\\/Hd\\\\\\\\\\\\\\\/ltoRta+8kku6g3uem5bl+tXBLvvB6q507C33y25PboBOMn08iGfJ9HzFF9Bq5yiAlM2wTlL8I8seTfP+qv6XLkt8SsRj3iQFUq8xUNettykvI\\\\\\\\\\\\\\\/hJlMfbm+bLPKtjH0cCINPJtqHBx74Y2X2wdLIuG2ycBeg\\\\\\\\\\\\\\\/4C\\\\\\\\\\\\\\\/FEcNkad9wV1aqMFDEdPsrP1NHUaetNLts5YR7riVMm3nfE2tODkBCCt2ZATiceov4YPLF07hNAl7PPqrniP9cX5AQ6smiL5ncJqTuZKlZYfzFQyF0HdbIwTWj6bb7eZ37Y2cXjTe+0lcxjC67B7AzEuz\\\\\\\\\\\\\\\/9PKYw9KCUINV2pMMNVB9DnIYpLwnx9wm19O8nwg53Y0sFm9xpnGkVmnYk1gbTKyjug3Suew4+WAgL2KUimSUJmK8WVzIsYZPPWTE16V2B4hFiRy6DT\\\\\\\\\\\\\\\/FUzicrORuTi\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/6Xb3SKscO6cXxnN5Pw5zs3w1Qokgoqs5z3uMgDJ5fIVGbkq2nhzQVAJFHdfD0K5uXfgpUsQFUy2hDqWPTnawpAolsK3xGfbb3RvL+oFhP655wSPCyeHY1ith0\\\\\\\\\\\\\\\/386v3\\\\\\\\\\\\\\\/nYD4kNFrIBRo54I\\\\\\\\\\\\\\\/vnPmo9dfEdA8k0mIHKsu9bkDKuPX1cmLHiihXcX36SQMUSe6Wb1FlhUa\\\\\\\\\\\\\\\/zbAy+LZ1OKCDj3cwKxp5f7Vhhbu6\\\\\\\\\\\\\\\/6NrFU5FIhVnIloJAe7TSivRQD2P4k73FaOTfEuBC6SFasgRB9Gc7Xzl\\\\\\\\\\\\\\\/kvgExZGL18uFH+imeytZPcyiuHdC8z+L2zqtbJ6ED2r3FE5IYA4dq27K3lLRQ8gMWxLsGF2j884+bH5TxciGQsUWOMwZG6+sIZ8RXtQLlWlWaRav9eDL+xqPLPrf4ZXyCcCFfxswA4CNr4zHTjCTStXHKCll6mFv9m+xVJhvXwa3Fa10Rk6SiZsLl75F5XqnHZQN4v+tfxEIO5+en5Kk4OZHui+sDLTWZpLCGIlKMzz2mYrE3uUO59xKXB5NUHhpZhPeAk76T7+WCYBnz8VH3OxIGNz+GS9Z142RyPNYvutF\\\\\\\\\\\\\\\/YXP22H+yofQyXDAUboFqoABl3PU2fbrLwwSXctjaurcPVbrh4KAd8kWNVK4IsRB6zfGReOsbhmDfei9Vc\\\\\\\\\\\\\\\/LAvXsZVcHZRXHuOE6d39YyBlv53H2JjN1ZQX\\\\\\\\\\\\\\\/NaxI3e3NOsfq1OpQKFgX+bQ6Iral+jSnJuZMqIZXlvWs90+MARL4HT\\\\\\\\\\\\\\\/+KGIky7psxdIBHWzErgoVE9l\\\\\\\\\\\\\\\/HCuUtaMUX6\\\\\\\\\\\\\\\/wYaWfwckNA6oNR+NdgeOOun\\\\\\\\\\\\\\\/qTNEhDy60AedNCpJsweSnuCZ\\\\\\\\\\\\\\\/4LWBDubVpojcXOfS6qEQDTDoPjRZI3zedWM\\\\\\\\\\\\\\\/7GE0MjmhMrQHiw4kBsM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022MM+XFJFbDvhTW5H+W26hrQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022de0d6868de52c9431edcfba9cd05a06612211fd2be446dcdf1b691abf8c857e0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/7\\\/1\\\/110.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/7\\\/1\\\/110.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-019-0590-4\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-019-0590-4\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-019-0590-4\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}